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http://hdl.handle.net/1942/39941
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DC Field | Value | Language |
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dc.contributor.author | SLAETS, Leen | - |
dc.contributor.author | FONTEYN, Lena | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.date.accessioned | 2023-04-20T08:28:17Z | - |
dc.date.available | 2023-04-20T08:28:17Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-04-14T12:22:22Z | - |
dc.identifier.citation | BRAIN BEHAVIOR AND IMMUNITY, 110 , p. 237 -244 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39941 | - |
dc.description.abstract | Frailty and a failing immune system lead to significant morbidities in the final years of life and bring along a significant burden on healthcare systems. The good news is that regular exercise provides an effective countermeasure for losing muscle tissue when we age while supporting proper immune system functioning. For a long time, it was assumed that exercise-induced immune responses are predominantly mediated by myeloid cells, but it has become evident that they receive important help from T lymphocytes. Skeletal muscles and T cells interact, not only in muscle pathology but also during exercise. In this review article, we provide an overview of the most important aspects of T cell senescence and discuss how these are modulated by exercise. In addition, we describe how T cells are involved in muscle regeneration and growth. A better understanding of the complex interactions between myocytes and T cells throughout all stages of life provides important insights needed to design strategies that effectively combat the wave of age-related diseases the world is currently faced with. | - |
dc.description.sponsorship | N.H. and B.O.E. received a grant (G040321FWO) from the Flemish Fund for Scientific Research (FWO Vlaanderen). N.H. and H.S. were also supported by the Interreg Euregio Meuse-Rine Healthy Aging project grant (EMR51), funded by the European Fund for Regional Development of the EU, supporting innovation in this region | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.rights | 2023 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Aging | - |
dc.subject.other | Exercise | - |
dc.subject.other | T cells | - |
dc.subject.other | Immune senescence | - |
dc.subject.other | Muscle | - |
dc.subject.other | Sarcopenia | - |
dc.title | Train your T cells: How skeletal muscles and T cells keep each other fit during aging | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 244 | - |
dc.identifier.spage | 237 | - |
dc.identifier.volume | 110 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hellings, N (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Neuroimmune Connect & Repair Lab, Diepenbeek, Belgium.; Hellings, N (corresponding author), UMSC Univ MS Ctr, Campus Diepenbeek, Diepenbeek, Belgium. | - |
dc.description.notes | niels.hellings@uhasselt.be | - |
local.publisher.place | 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.bbi.2023.03.006 | - |
dc.identifier.pmid | 36893922 | - |
dc.identifier.isi | 000956260500001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Slaets, Helena; Fonteyn, Lena; Hellings, Niels] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Neuroimmune Connect & Repair Lab, Diepenbeek, Belgium. | - |
local.description.affiliation | [Fonteyn, Lena; Eijnde, Bert] Hasselt Univ, Fac Med & Life Sci, SMRC Sports Med Res Ctr, BIOMED Biomed Res Inst, Diepenbeek, Belgium. | - |
local.description.affiliation | [Hellings, Niels] UMSC Univ MS Ctr, Campus Diepenbeek, Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | SLAETS, Leen | - |
item.contributor | FONTEYN, Lena | - |
item.contributor | OP 'T EIJNDE, Bert | - |
item.contributor | HELLINGS, Niels | - |
item.fullcitation | SLAETS, Leen; FONTEYN, Lena; OP 'T EIJNDE, Bert & HELLINGS, Niels (2023) Train your T cells: How skeletal muscles and T cells keep each other fit during aging. In: BRAIN BEHAVIOR AND IMMUNITY, 110 , p. 237 -244. | - |
crisitem.journal.issn | 0889-1591 | - |
crisitem.journal.eissn | 1090-2139 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Train your T cells_ How skeletal muscles and T cells keep each other fit during aging.pdf Restricted Access | Published version | 2.68 MB | Adobe PDF | View/Open Request a copy |
Train your T cells.pdf | Peer-reviewed author version | 1.27 MB | Adobe PDF | View/Open |
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