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http://hdl.handle.net/1942/39971
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DC Field | Value | Language |
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dc.contributor.author | HOUBEN, Sofie | - |
dc.contributor.author | Aldana, Ana A. | - |
dc.contributor.author | Huysecom, An-Sofie | - |
dc.contributor.author | Mpinganzima, Winy | - |
dc.contributor.author | Cardinaels, Ruth | - |
dc.contributor.author | Baker, Matthew B. | - |
dc.contributor.author | PITET, Louis | - |
dc.date.accessioned | 2023-04-24T13:30:49Z | - |
dc.date.available | 2023-04-24T13:30:49Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-04-07T10:25:13Z | - |
dc.identifier.citation | ACS Applied Polymer Materials, 5 (3) , p. 1819 -1827 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39971 | - |
dc.description.abstract | Compositional changes in the chemical makeup of hydrogels offer a powerful strategy for fine tuning of mechanical properties, enabling specific targeting for different applications. The chemical versatility exhibited by the tunable system introduced here can be leveraged to address a broad range of characteristics across the field of tissue engineering-from blood vessels to cartilage, for example-which demands materials with very different mechanical profiles. Furthermore, we rely exclusively on dynamic, non-covalent cross-linking to provide opportunities for 3D printing and injectability. This work describes a highly tunable system based on hydrogen bonding and ionic interactions. Single network hydrogels were made by exploiting various acrylic monomers including N-acryloyl glycinamide (NAGA) and acrylic acid (AAc). Additionally, hybrid hydrogels were explored by combining these acrylic networks with an ionically cross-linked alginate network. By combining orthogonal cross-linking strategies and altering the ratio between different components in these hybrid gels, a broad range of mechanical properties is demonstrated. The characteristics were extensively investigated using tensile testing, compression testing, and rheological measurements. The final scaffolds were also shown to be non-cytotoxic in preliminary cell viability studies for human dermal fibroblasts. | - |
dc.description.sponsorship | The authors are grateful for partial support (L.M.P., A.A.A., and M.B.B.) from the Research Foundation-Flanders (FWO) under contract G080020N. S.H. is grateful for funding from a BOF-OWB mandate under contract BOF19OWB08. A.-S.H. is grateful to Research Foundation-Flanders (FWO) for a PhD fellowship for fundamental research with file numbers 1180319N and 1180321N. This research has also been made possible with support of NWO (Innovation Fund Chemistry, project “DynAM” under project agreement 731.016.202) and the Dutch Ministry of Economic Affairs. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | 2023 American Chemical Society | - |
dc.subject.other | interpenetrating network hydrogels | - |
dc.subject.other | hybrid hydrogels | - |
dc.subject.other | dynamic crosslinking | - |
dc.subject.other | tissue engineering | - |
dc.title | Hybrid Hydrogels with Orthogonal Transient Cross-linking Exhibiting Highly Tunable Mechanical Properties | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1827 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1819 | - |
dc.identifier.volume | 5 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Pitet, LM (corresponding author), Hasselt Univ, Inst Mat Res Imo Imomec, Adv Funct Polymers AFP Grp, B-3500 Hasselt, Belgium.; Baker, MB (corresponding author), Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, NL-6200 MD Maastricht, Netherlands. | - |
dc.description.notes | m.baker@maastrichtuniversity.nl; Louis.pitet@uhasselt.be | - |
local.publisher.place | 1155 16TH ST, NW, WASHINGTON, DC 20036 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1021/acsapm.2c01906 | - |
dc.identifier.isi | 000952982600001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Houben, Sofie; Mpinganzima, Winy; Pitet, Louis M.] Hasselt Univ, Inst Mat Res Imo Imomec, Adv Funct Polymers AFP Grp, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Aldana, Ana A.; Baker, Matthew B.] Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, NL-6200 MD Maastricht, Netherlands. | - |
local.description.affiliation | [Huysecom, An-Sofie; Cardinaels, Ruth] Katholieke Univ Leuven, Dept Chem Engn, Soft Matter Rheol & Technol, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | HOUBEN, Sofie; Aldana, Ana A.; Huysecom, An-Sofie; Mpinganzima, Winy; Cardinaels, Ruth; Baker, Matthew B. & PITET, Louis (2023) Hybrid Hydrogels with Orthogonal Transient Cross-linking Exhibiting Highly Tunable Mechanical Properties. In: ACS Applied Polymer Materials, 5 (3) , p. 1819 -1827. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.contributor | HOUBEN, Sofie | - |
item.contributor | Aldana, Ana A. | - |
item.contributor | Huysecom, An-Sofie | - |
item.contributor | Mpinganzima, Winy | - |
item.contributor | Cardinaels, Ruth | - |
item.contributor | Baker, Matthew B. | - |
item.contributor | PITET, Louis | - |
crisitem.journal.issn | 2637-6105 | - |
crisitem.journal.eissn | 2637-6105 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Hybrid Hydrogels with Orthogonal Transient Cross-linking Exhibiting Highly Tunable Mechanical Properties.pdf Restricted Access | Published version | 9.37 MB | Adobe PDF | View/Open Request a copy |
NAGA_Manuscript_Clean_2ndRev.pdf | Peer-reviewed author version | 10.19 MB | Adobe PDF | View/Open |
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