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http://hdl.handle.net/1942/39974
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DC Field | Value | Language |
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dc.contributor.author | VERWERFT, Jan | - |
dc.contributor.author | Soens, Lucie | - |
dc.contributor.author | Wynants, Jokke | - |
dc.contributor.author | Meysman, Marc | - |
dc.contributor.author | Jogani, Siddharth | - |
dc.contributor.author | Plein, Danielle | - |
dc.contributor.author | Stroobants , Sarah | - |
dc.contributor.author | HERBOTS, Lieven | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.date.accessioned | 2023-04-24T14:08:52Z | - |
dc.date.available | 2023-04-24T14:08:52Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-04-05T14:50:51Z | - |
dc.identifier.citation | EUROPEAN HEART JOURNAL, 44 (17) , p. 1544-1556 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39974 | - |
dc.description.abstract | Background and aims Heart failure with preserved ejection fraction (HFpEF) is a syndrome with a heterogeneous presentation. This study provides an in-;depth description of haemodynamic and metabolic alterations revealed by systematic assessment through cardiopulmonary exercise testing combined with exercise echocardiography (CPETecho) within a dedicated dyspnoea clinic. Methods and results Consecutive patients (n = 297), referred to a dedicated dyspnoea clinic using a standardized workup including CPETecho, with HFpEF diagnosed through a H2FPEF score >= 6 or HFA-PEFF score >= 5, were evaluated. A median of four haemodynamic/metabolic alterations was uncovered per patient: impaired stroke volume reserve (73%), impaired chronotropic reserve (72%), exercise pulmonary hypertension (65%), and impaired diastolic reserve (64%) were the most frequent cardiac alterations. Impaired peripheral oxygen extraction and a ventilatory limitation were present in 40% and 39%, respectively. In 267 patients (90%), 575 further diagnostic examinations were recommended (median of two tests per patient). Cardiac magnetic resonance imaging, coronary or amyloidosis workup, ventilation-perfusion scanning, and pulmonology referral were each recommended in approximately one out of three patients. In 293 patients (99%), 929 cardiovascular drug optimizations were performed (median of 3 modifications per patient). In 110 patients (37%), 132 cardiovascular interventions were performed, with ablation as the most frequent procedure. Conclusion Holistic workup of HFpEF patients within a multidisciplinary, dedicated dyspnoea clinic, including systematic implementation of CPETecho reveals various haemodynamic/metabolic alterations, leading to further diagnostic testing and potential treatment changes in the majority of cases. | - |
dc.description.sponsorship | The authors thank all the cardiology fellows who have contributed in performing the exams in the dyspnoea clinic of Jessa Hospital (Hasselt, Belgium) over the years. In addition, a special thanks go to Nancy De Laet, Mathilde De Dobbeleer, Daisy Thys, and Peter Vanvoorden for their vital paramedic support in the clinic. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | - |
dc.subject.other | Diastolic heart failure | - |
dc.subject.other | Dyspnoea | - |
dc.subject.other | Echocardiography | - |
dc.subject.other | Exercise test | - |
dc.subject.other | Therapeutics | - |
dc.title | Heart failure with preserved ejection fraction: relevance of a dedicated dyspnoea clinic | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1556 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | 1544 | - |
dc.identifier.volume | 44 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Verbrugge, FH (corresponding author), Univ Hosp Brussels, Ctr Cardiovasc Dis, Laarbeeklaan 101, B-1090 Jette, Belgium.; Verbrugge, FH (corresponding author), Vrije Univ Brussel, Fac Med & Pharm, Pleinlaan 2, B-1050 Elsene, Belgium. | - |
dc.description.notes | frederik.verbrugge@uzbrussel.be | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/eurheartj/ehad141 | - |
dc.identifier.pmid | 36924194 | - |
dc.identifier.isi | 000950351400001 | - |
dc.contributor.orcid | Verwerft, Jan/0000-0003-2697-0825 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Verwerft, Jan; Jogani, Siddharth; Stroobants, Sarah; Herbots, Lieven] Jessa Hosp, Dept Cardiol, Stadsomvaart 11, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Verwerft, Jan; Herbots, Lieven] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Soens, Lucie; Plein, Danielle; Verbrugge, Frederik H.] Univ Hosp Brussels, Ctr Cardiovasc Dis, Laarbeeklaan 101, B-1090 Jette, Belgium. | - |
local.description.affiliation | [Wynants, Jokke] Jessa Hosp, Dept Pulmonol, Stadsomvaart 11, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Meysman, Marc] Univ Hosp Brussels, Dept Pulmonol, Laarbeeklaan 101, B-1090 Jette, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Vrije Univ Brussel, Fac Med & Pharm, Pleinlaan 2, B-1050 Elsene, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | VERWERFT, Jan; Soens, Lucie; Wynants, Jokke; Meysman, Marc; Jogani, Siddharth; Plein, Danielle; Stroobants , Sarah; HERBOTS, Lieven & VERBRUGGE, Frederik (2023) Heart failure with preserved ejection fraction: relevance of a dedicated dyspnoea clinic. In: EUROPEAN HEART JOURNAL, 44 (17) , p. 1544-1556. | - |
item.contributor | VERWERFT, Jan | - |
item.contributor | Soens, Lucie | - |
item.contributor | Wynants, Jokke | - |
item.contributor | Meysman, Marc | - |
item.contributor | Jogani, Siddharth | - |
item.contributor | Plein, Danielle | - |
item.contributor | Stroobants , Sarah | - |
item.contributor | HERBOTS, Lieven | - |
item.contributor | VERBRUGGE, Frederik | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0195-668X | - |
crisitem.journal.eissn | 1522-9645 | - |
Appears in Collections: | Research publications |
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Heart failure with preserved ejection fraction_ relevance of a dedicated dyspnoea clinic.pdf | Published version | 1.59 MB | Adobe PDF | View/Open |
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