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Title: | Steroid-dependent pericarditis following anti-PD1 immunotherapy in a metastatic melanoma patient: a case report | Authors: | Verhaert, Marthe MEBIS, Jeroen Aspeslagh, Sandrine von Kemp, Berlinde |
Editors: | Rossi, Valentina Komorovsky, Roman Gambaro, Alessia Kovacs, Boldizsar Peverelli, Marta Jathanna, Nikesh |
Issue Date: | 2023 | Publisher: | OXFORD UNIV PRESS | Source: | European Heart Journal: Case Reports, 7 (3) , p. 1 -5 | Abstract: | Background Immune-related adverse events are increasingly prevalent in the oncologist's practice. Cardiac adverse events are rare but can be life-threatening. Case reports of immune checkpoint inhibitor (ICI)-related pericarditis are scarce and so is the scientific evidence for its management. This is the first report of a steroid-dependent pericarditis. Case summary We present a case of a woman with lung metastatic melanoma who developed pericarditis after two infusions of pembrolizumab. The initial response to steroids and colchicine was favourable, and steroids were successfully tapered, after which the immunotherapy was reintroduced. A complete metabolic remission was achieved after six cycles of pembrolizumab, but pericarditis symptoms recur each time the steroid dose is lowered below 10 mg. After introduction of azathioprine, steroids were successfully tapered over the course of 6 months. Discussion Because of the chronicity of the pericarditis, it was hypothesized that an underlying auto-immune pericarditis was triggered by the checkpoint inhibitor and the general guidelines for recurrent idiopathic pericarditis were followed, successfully adding azathioprine to taper steroids to stop. | Notes: | Verhaert, M (corresponding author), UZ Brussel, Med Oncol, Laarbeeklaan 101, B-1090 Jette, Belgium. marthe.verhaert@uzbrussel.be |
Keywords: | Immune-related adverse events;Pericard;itis;Immune checkpoint inhibitors;Cardiotoxicity;Case report | Document URI: | http://hdl.handle.net/1942/39996 | e-ISSN: | 2514-2119 | DOI: | 10.1093/ehjcr/ytad112 | ISI #: | 000953027700004 | Rights: | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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