Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/40141
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dc.contributor.authorVerleye, Arno-
dc.contributor.authorWijtvliet, Veerle-
dc.contributor.authorABRAMS, Steven-
dc.contributor.authorHellemans, Rachel-
dc.contributor.authorBougrea, Rania-
dc.contributor.authorMassart, Annick-
dc.contributor.authorPipeleers, Lissa-
dc.contributor.authorWissing, Karl Martin-
dc.contributor.authorAriën, Kevin K-
dc.contributor.authorDe Winter, Benedicte Y-
dc.contributor.authorVan Damme, Pierre-
dc.contributor.authorAbramowicz, Daniel-
dc.contributor.authorLedeganck, Kristien J-
dc.date.accessioned2023-05-24T08:50:13Z-
dc.date.available2023-05-24T08:50:13Z-
dc.date.issued2022-
dc.date.submitted2023-05-22T14:32:06Z-
dc.identifier.citationNephrology, dialysis, transplantation, 37 (8) , p. 1566 -1575-
dc.identifier.urihttp://hdl.handle.net/1942/40141-
dc.description.abstractBackground.Inthegeneralpopulation,theseroconversion rateafterprimaryvaccinationwithtwodosesofanantisevereacuterespiratorysyndromecoronavirus2messenger RNA(mRNA)vaccinereachesnearly100%,withsignificantly higherantibodytitersaftermRNA-1273vaccinationcompared toBNT162b2vaccination.Hereweperformedasystematic reviewandmeta-analysistocomparetheantibodyresponse aftertwo-dosemRNA-1273versusBNT162b2vaccinationin solidorgantransplant(SOT)recipients. Methods.Asystematicliteraturereviewwasperformedusing PubMed,WebofScienceandtheCochraneLibraryand originalresearchpaperswereincludedforameta-analysisto calculatevaccine-specificseroconversionratesforeachofthe mRNAvaccines.Next,thepooledrelativeseroconversionrate wasestimated. Results.Eightstudiesthatdescribedthedevelopmentofantibodiesagainstreceptor-bindingdomain(RBD)and/orspike proteinwereeligibleformeta-analysis.Twoofthesestudies alsoreportedantibodytiters.Themeta-analysisrevealedlower seroconversionratesinSOTrecipientsvaccinatedwithtwo dosesofBNT162b2{44.3%[95%confidenceinterval(CI) 34.1–54.7]}ascomparedwithpatientsvaccinatedwithtwo dosesofmRNA-1273[58.4%(95%CI47.2–69.2)].Therelative seroconversionratewas0.795(95%CI0.732–0.864). Conclusions.Thissystematicreviewandmeta-analysis indicatesthatinSOTrecipients,higherseroconversionrates wereobservedaftervaccinationwithmRNA-1273compared withBNT162b2.-
dc.description.sponsorshipNofundingwasreceivedtoassistwiththepreparationofthis manuscript. TheauthorswouldliketothankErikSneldersforhis outstandingsecretarialhelp.-
dc.language.isoen-
dc.publisher-
dc.rightsThe Author(s) 2022.Published by Oxford University Presson behalf of the ERA. Allrights reserved. For permissions, please e-mail: journals.permissions@oup.com. Free access-
dc.titleSeroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis-
dc.typeJournal Contribution-
dc.identifier.epage1575-
dc.identifier.issue8-
dc.identifier.spage1566-
dc.identifier.volume37-
local.format.pages10-
local.bibliographicCitation.jcatA1-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1093/ndt/gfac174-
local.provider.typeCrossRef-
local.uhasselt.internationalno-
item.fulltextWith Fulltext-
item.contributorVerleye, Arno-
item.contributorWijtvliet, Veerle-
item.contributorABRAMS, Steven-
item.contributorHellemans, Rachel-
item.contributorBougrea, Rania-
item.contributorMassart, Annick-
item.contributorPipeleers, Lissa-
item.contributorWissing, Karl Martin-
item.contributorAriën, Kevin K-
item.contributorDe Winter, Benedicte Y-
item.contributorVan Damme, Pierre-
item.contributorAbramowicz, Daniel-
item.contributorLedeganck, Kristien J-
item.fullcitationVerleye, Arno; Wijtvliet, Veerle; ABRAMS, Steven; Hellemans, Rachel; Bougrea, Rania; Massart, Annick; Pipeleers, Lissa; Wissing, Karl Martin; Ariën, Kevin K; De Winter, Benedicte Y; Van Damme, Pierre; Abramowicz, Daniel & Ledeganck, Kristien J (2022) Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis. In: Nephrology, dialysis, transplantation, 37 (8) , p. 1566 -1575.-
item.validationvabb 2024-
item.accessRightsOpen Access-
crisitem.journal.issn0931-0509-
crisitem.journal.eissn1460-2385-
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