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http://hdl.handle.net/1942/40234
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DC Field | Value | Language |
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dc.contributor.author | Mussen, Femke | - |
dc.contributor.author | VAN BROECKHOVEN, Jana | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | SCHEPERS, Melissa | - |
dc.contributor.author | VANMIERLO, Tim | - |
dc.date.accessioned | 2023-06-01T08:48:26Z | - |
dc.date.available | 2023-06-01T08:48:26Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-05-31T11:42:53Z | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (9) (Art N° 8135) | - |
dc.identifier.uri | http://hdl.handle.net/1942/40234 | - |
dc.description.abstract | Traumatic spinal cord injury (SCI) is characterized by severe neuroinflammation and hampered neuroregeneration, which often leads to permanent neurological deficits. Current therapies include decompression surgery, rehabilitation, and in some instances, the use of corticosteroids. However, the golden standard of corticosteroids still achieves minimal improvements in functional outcomes. Therefore, new strategies tackling the initial inflammatory reactions and stimulating endogenous repair in later stages are crucial to achieving functional repair in SCI patients. Cyclic adenosine monophosphate (cAMP) is an important second messenger in the central nervous system (CNS) that modulates these processes. A sustained drop in cAMP levels is observed during SCI, and elevating cAMP is associated with improved functional outcomes in experimental models. cAMP is regulated in a spatiotemporal manner by its hydrolyzing enzyme phosphodiesterase (PDE). Growing evidence suggests that inhibition of cAMP-specific PDEs (PDE4, PDE7, and PDE8) is an important strategy to orchestrate neuroinflammation and regeneration in the CNS. Therefore, this review focuses on the current evidence related to the immunomodulatory and neuroregenerative role of cAMP-specific PDE inhibition in the SCI pathophysiology. | - |
dc.description.sponsorship | The APC was funded by FWO (G042121N and 1209123N) | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | traumatic spinal cord injury | - |
dc.subject.other | cAMPphosphodiesterases | - |
dc.subject.other | neuroinflammation | - |
dc.subject.other | regeneration | - |
dc.title | Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 9 | - |
dc.identifier.volume | 24 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Schepers, M; Vanmierlo, T (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Dept Neurosci, B-3590 Diepenbeek, Belgium.; Schepers, M; Vanmierlo, T (corresponding author), Hasselt Univ, Univ MS Ctr UMSC Hasselt Pelt, B-3500 Hasselt, Belgium.; Schepers, M; Vanmierlo, T (corresponding author), Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, NL-6229ER Maastricht, Netherlands. | - |
dc.description.notes | melissa.schepers@uhasselt.be; t.vanmierlo@maastrichtuniversity.nl | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 8135 | - |
dc.identifier.doi | 10.3390/ijms24098135 | - |
dc.identifier.pmid | 37175842 | - |
dc.identifier.isi | 000986817200001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mussen, Femke; Schepers, Melissa; Vanmierlo, Tim] Hasselt Univ, Biomed Res Inst BIOMED, Dept Neurosci, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Mussen, Femke; Broeckhoven, Jana Van; Hellings, Niels; Schepers, Melissa; Vanmierlo, Tim] Hasselt Univ, Univ MS Ctr UMSC Hasselt Pelt, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Broeckhoven, Jana Van; Hellings, Niels] Hasselt Univ, Biomed Res Inst BIOMED, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Schepers, Melissa; Vanmierlo, Tim] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, NL-6229ER Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.contributor | Mussen, Femke | - |
item.contributor | VAN BROECKHOVEN, Jana | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | SCHEPERS, Melissa | - |
item.contributor | VANMIERLO, Tim | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Mussen, Femke; VAN BROECKHOVEN, Jana; HELLINGS, Niels; SCHEPERS, Melissa & VANMIERLO, Tim (2023) Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (9) (Art N° 8135). | - |
crisitem.journal.issn | 1661-6596 | - |
crisitem.journal.eissn | 1422-0067 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Unleashing Spinal Cord Repair_ The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury.pdf | Published version | 828.95 kB | Adobe PDF | View/Open |
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