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http://hdl.handle.net/1942/40258| Title: | Salt sensitivity includes effects on immune cell signalling and metabolism | Authors: | Mueller, Dominik N. Geisberger, Sabrina KLEINEWIETFELD, Markus Jantsch, Jonathan |
Issue Date: | 2023 | Publisher: | NATURE PORTFOLIO | Source: | NATURE REVIEWS IMMUNOLOGY, 23 (6) , p. 341 -342 | Abstract: | Excess salt (sodium chloride) intake is a risk factor for hypertension and is attributed to increasing rates of morbidity and mortality from cardiovascular diseases. Salt sensitivity is classically defined as the blood pressure response to dietary salt changes. However, in addition to the pivotal role of sodium (Na+) in regulating the osmotic composition of body fluids, we recently reported that Na+ regulates the energy metabolism of immune cells. Thus, we suggest broadening the definition of salt sensitivity to include these effects on cellular immunometabolism. | Notes: | Muller, DN (corresponding author), Helmholtz Assoc, Max Delbruck Ctr Mol Med, Berlin, Germany.; Muller, DN (corresponding author), Charite Univ Med Berlin, Berlin, Germany.; Muller, DN (corresponding author), DZHK German Ctr Cardiovasc Res, Berlin, Germany.; Kleinewietfeld, M (corresponding author), Hasselt Univ, VIB Ctr Inflammat Res IRC, Lab Translat Immunomodulat, Diepenbeek, Belgium.; Kleinewietfeld, M (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol, Diepenbeek, Belgium.; Kleinewietfeld, M (corresponding author), Hasselt Univ, Univ Multiple Sclerosis Ctr UMSC, Diepenbeek, Belgium.; Jantsch, J (corresponding author), Univ Hosp Regensburg, Inst Clin Microbiol & Hyg, Regensburg, Germany.; Jantsch, J (corresponding author), Univ Regensburg, Regensburg, Germany.; Jantsch, J (corresponding author), Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany.; Jantsch, J (corresponding author), Univ Cologne, Univ Hosp Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany.; Jantsch, J (corresponding author), Univ Cologne, Fac Med, Cologne, Germany. dominik.mueller@mdc-berlin.de; markus.kleinewietfeld@uhasselt.vib.be; jonathan.jantsch@uk-koeln.de |
Document URI: | http://hdl.handle.net/1942/40258 | ISSN: | 1474-1733 | e-ISSN: | 1474-1741 | DOI: | 10.1038/s41577-023-00881-x | ISI #: | 000975265800002 | Category: | A2 | Type: | Journal Contribution |
| Appears in Collections: | Research publications |
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