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http://hdl.handle.net/1942/40278
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DC Field | Value | Language |
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dc.contributor.author | de Punder, Karin | - |
dc.contributor.author | Heim, Christine | - |
dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | Wadhwa, Pathik D. | - |
dc.contributor.author | Entringer, Sonja | - |
dc.date.accessioned | 2023-06-05T09:44:40Z | - |
dc.date.available | 2023-06-05T09:44:40Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-06-02T14:14:54Z | - |
dc.identifier.citation | PSYCHONEUROENDOCRINOLOGY, 153 (Art N° 106120) | - |
dc.identifier.uri | http://hdl.handle.net/1942/40278 | - |
dc.description.abstract | Exposure to various forms of stress has been associated with shorter telomere length (TL). However, the molecular underpinnings of this effect are poorly understood. Based on an understanding of the key role of the reverse transcriptase enzyme telomerase in regulating TL, and building upon our previous work in developing and validating a biomarker of the capacity of cells to express telomerase (maximal telomerase activity capacity (mTAC)), we examine here the hypotheses that mTAC is positively associated with TL and that the effect of stress on TL is mediated by individual differences in mTAC. In a proof-of-principle study of 28 healthy women and men we quantified the cortisol response to a standardized stress challenge, the Trier Social Stress Test (TSST), and we concurrently assessed peripheral blood mononuclear cell (PBMC) mTAC and TL. Our results indicated that higher mTAC levels were associated with longer TL (r = 0.50, p = .01). Moreover, mediational analysis suggested that the effect of the cortisol stress response on TL was mediated by mTAC (completely standardized beta = -0.17, bootstrap CI95 %: -0.44 to -0.01). Thus, our findings support the premise that individual differences in the capacity of cells to up-regulate telomerase may represent a key mediator in the link between stress and TL. | - |
dc.description.sponsorship | Funding for this study was provided by grants from Neurocure (Innovation Projects) and the Federal Ministry of Education and Research (01KR1301A). P.D.W. and S.E.’s efforts were also supported, in part, by US PHS (NIH) grants (R01 HD-065825, R01 HD-060628 and R01 AG-050455). D.S.M. was supported by the Research Foundation Flanders (12X9620N, 12X9623N). | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.rights | 2023 Elsevier Ltd. All rights reserved | - |
dc.subject.other | Telomerase activity | - |
dc.subject.other | Telomere length | - |
dc.subject.other | Stress | - |
dc.subject.other | Peripheral blood mononuclear cell (PBMC) | - |
dc.subject.other | Cortisol | - |
dc.title | Maximal telomerase activity capacity (mTAC) underlies the link between the cortisol response to stress and telomere length | - |
dc.type | Journal Contribution | - |
dc.identifier.spage | 106120 | - |
dc.identifier.volume | 153 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | de Punder, K (corresponding author), Univ Innsbruck, Dept Psychol, Clin Psychol II, Innsbruck, Austria. | - |
dc.description.notes | Karin.De-Punder@uibk.ac.at | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 106120 | - |
dc.identifier.doi | 10.1016/j.psyneuen.2023.106120 | - |
dc.identifier.pmid | 37104965 | - |
dc.identifier.isi | 000989490400001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [de Punder, Karin; Heim, Christine; Entringer, Sonja] Charite Univ Med Berlin, D-10117 Berlin, Germany. | - |
local.description.affiliation | [de Punder, Karin; Heim, Christine; Entringer, Sonja] Free Univ Berlin, D-10117 Berlin, Germany. | - |
local.description.affiliation | [de Punder, Karin; Heim, Christine; Entringer, Sonja] Humboldt Univ, Inst Med Psychol, D-10117 Berlin, Germany. | - |
local.description.affiliation | [de Punder, Karin] Univ Innsbruck, Dept Psychol, Clin Psychol II, Innsbruck, Austria. | - |
local.description.affiliation | [Heim, Christine] Penn State Univ, Coll Hlth & Human Dev, Ctr Safe & Hlth Children, State Coll, PA USA. | - |
local.description.affiliation | [Martens, Dries S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Wadhwa, Pathik D.] Univ Calif Irvine, Sch Med, Dept Psychiat & Human Behav, Irvine, CA USA. | - |
local.description.affiliation | [Wadhwa, Pathik D.] Univ Calif Irvine, Sch Med, Dept Obstet & Gynecol, Irvine, CA USA. | - |
local.description.affiliation | [Wadhwa, Pathik D.; Entringer, Sonja] Univ Calif Irvine, Sch Med, Dept Pediat, Irvine, CA USA. | - |
local.description.affiliation | [Wadhwa, Pathik D.] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA USA. | - |
local.description.affiliation | [Wadhwa, Pathik D.; Entringer, Sonja] Univ Calif Irvine, Sch Med, Dev Hlth & Dis Res Program, Irvine, CA USA. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | de Punder, Karin | - |
item.contributor | Heim, Christine | - |
item.contributor | MARTENS, Dries | - |
item.contributor | Wadhwa, Pathik D. | - |
item.contributor | Entringer, Sonja | - |
item.fullcitation | de Punder, Karin; Heim, Christine; MARTENS, Dries; Wadhwa, Pathik D. & Entringer, Sonja (2023) Maximal telomerase activity capacity (mTAC) underlies the link between the cortisol response to stress and telomere length. In: PSYCHONEUROENDOCRINOLOGY, 153 (Art N° 106120). | - |
crisitem.journal.issn | 0306-4530 | - |
crisitem.journal.eissn | 1873-3360 | - |
Appears in Collections: | Research publications |
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