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http://hdl.handle.net/1942/4028
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DC Field | Value | Language |
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dc.contributor.author | WOUTERS, Kristien | - |
dc.contributor.author | Ahnaou, Abdellah | - |
dc.contributor.author | CORTINAS ABRAHANTES, Jose | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | GEYS, Helena | - |
dc.contributor.author | BIJNENS, Luc | - |
dc.contributor.author | Drinkenburg, Wilhelmus H. I. M. | - |
dc.date.accessioned | 2007-12-07T14:47:00Z | - |
dc.date.available | 2007-12-07T14:47:00Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, 56. p. 223-234 | - |
dc.identifier.issn | 0035-9254 | - |
dc.identifier.uri | http://hdl.handle.net/1942/4028 | - |
dc.description.abstract | The aim of the paper is to present methodology for the classification of potential psychotropic drugs on the basis of their activity. We first sketch the background of this class of drugs and then zoom in on so-called pharmacoelectroencephalogram studies. These data pose some statistical challenges. For classification purposes, we propose a flexible hierarchical discriminant analysis tool, allowing us to take the specific nature of the drug class into account, as well as the features of the mixed models, in combination with fractional polynomials, fitted to the electroencephalogram data. The method is evaluated against the background of existing methods. The method's performance is studied by using a comprehensive analysis of a large electroencephalogram data set. | - |
dc.description.sponsorship | The authors gratefully acknowledge the financial support from the Interuniversity AttractionPoles research network P6/03 ‘Statistical techniques and modeling for complex substantivequestions with complex data’ of the Belgian Government (Belgian science policy). | - |
dc.language.iso | en | - |
dc.publisher | BLACKWELL PUBLISHING | - |
dc.rights | (C) 2007 Royal Statistical Society | - |
dc.subject.other | discriminant analysis; electroencephalogram; fractional polynomials; longitudinal data; mixed model | - |
dc.subject.other | discriminant analysis; electroencephalogram; fractional polynomials; longitudinal data; mixed model | - |
dc.title | Psychotropic drug classification based on sleep-wake behaviour of rats | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 234 | - |
dc.identifier.spage | 223 | - |
dc.identifier.volume | 56 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Univ Hasselt, Ctr Stat, B-3590 Diepenbeek, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Beerse, Belgium.WOUTERS, K, Univ Hasselt, Ctr Stat, Univ Campus, B-3590 Diepenbeek, Belgium.Kristien.WOUTERS@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1111/j.1467-9876.2007.00575.x | - |
dc.identifier.isi | 000245159600007 | - |
item.validation | ecoom 2008 | - |
item.fullcitation | WOUTERS, Kristien; Ahnaou, Abdellah; CORTINAS ABRAHANTES, Jose; MOLENBERGHS, Geert; GEYS, Helena; BIJNENS, Luc & Drinkenburg, Wilhelmus H. I. M. (2007) Psychotropic drug classification based on sleep-wake behaviour of rats. In: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, 56. p. 223-234. | - |
item.contributor | WOUTERS, Kristien | - |
item.contributor | Ahnaou, Abdellah | - |
item.contributor | CORTINAS ABRAHANTES, Jose | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | GEYS, Helena | - |
item.contributor | BIJNENS, Luc | - |
item.contributor | Drinkenburg, Wilhelmus H. I. M. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0035-9254 | - |
crisitem.journal.eissn | 1467-9876 | - |
Appears in Collections: | Research publications |
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Wouters_et_al-2007-Journal_of_the_Royal_Statistical_Society-_Series_C_(Applied_Statistics).pdf Restricted Access | Published version | 539.35 kB | Adobe PDF | View/Open Request a copy |
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