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http://hdl.handle.net/1942/4032
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DC Field | Value | Language |
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dc.contributor.author | TILAHUN ESHETE, Abel | - |
dc.contributor.author | Pryseley, Assam | - |
dc.contributor.author | ALONSO ABAD, Ariel | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.date.accessioned | 2007-12-07T14:50:31Z | - |
dc.date.available | 2007-12-07T14:50:31Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | COMPUTATIONAL STATISTICS & DATA ANALYSIS, 51(9). p. 4152-4163 | - |
dc.identifier.issn | 0167-9473 | - |
dc.identifier.uri | http://hdl.handle.net/1942/4032 | - |
dc.description.abstract | The evaluation of surrogate endpoints is thought to be first studied by Prentice, who presented a definition of a surrogate as well as a set of criteria. These criteria were later supplemented with the so-called proportion explained after notifying some drawbacks in Prentice's approach. Subsequently, the evaluation exercise was framed within a meta-analytic setting, thereby overcoming difficulties that necessarily surround evaluation efforts based on a single trial. The meta-analytic approach for continuous outcomes is briefly reviewed. Advantages and problems are highlighted by means of two case studies, one in schizophrenia and one in ophthalmology, and a simulation study. One of the critical issues for the broad adoption of methodology like the one presented here is the availability of flexible implementations in standard statistical software. Generically applicable SAS macros and R functions are developed and made available to the reader. (c) 2007 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | We gratefully acknowledge support from Belgian IUAP/PAI network “Statistical Techniques and Modeling for Complex Substantive Questions with Complex Data”. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2007 Elsevier B.V. All rights reserved | - |
dc.subject.other | adjusted association; hierarchical model; meta-analysis; proportion explained; random-effects model; relative effect; surrogate endpoint | - |
dc.subject.other | adjusted association; hierarchical model; meta-analysis; proportion explained; random-effects model; relative effect; surrogate endpoint | - |
dc.title | Flexible surrogate marker evaluation from several randomized clinical trials with continuous endpoints, using R and SAS | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4163 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 4152 | - |
dc.identifier.volume | 51 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium.MOLENBERGHS, G, Hasselt Univ, Ctr Stat, Agoralaan 1, B-3590 Diepenbeek, Belgium.geert.molenberghs@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
local.bibliographicCitation.artnr | R07008 | - |
dc.identifier.doi | 10.1016/j.csda.2007.02.007 | - |
dc.identifier.isi | 000246606000005 | - |
item.fullcitation | TILAHUN ESHETE, Abel; Pryseley, Assam; ALONSO ABAD, Ariel & MOLENBERGHS, Geert (2007) Flexible surrogate marker evaluation from several randomized clinical trials with continuous endpoints, using R and SAS. In: COMPUTATIONAL STATISTICS & DATA ANALYSIS, 51(9). p. 4152-4163. | - |
item.contributor | TILAHUN ESHETE, Abel | - |
item.contributor | Pryseley, Assam | - |
item.contributor | ALONSO ABAD, Ariel | - |
item.contributor | MOLENBERGHS, Geert | - |
item.validation | ecoom 2008 | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0167-9473 | - |
crisitem.journal.eissn | 1872-7352 | - |
Appears in Collections: | Research publications |
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a.pdf Restricted Access | Published version | 181.23 kB | Adobe PDF | View/Open Request a copy |
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