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http://hdl.handle.net/1942/40356
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DC Field | Value | Language |
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dc.contributor.author | BONGAERTS, Eva | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | WANG, Congrong | - |
dc.contributor.author | AMELOOT, Marcel | - |
dc.contributor.author | BOVE, Hannelore | - |
dc.contributor.author | Roeffaers, Maarten B. J. | - |
dc.contributor.author | Chavatte-Palmer, Pascale | - |
dc.contributor.author | Couturier-Tarrade, Anne | - |
dc.contributor.author | Cassee, Flemming R. | - |
dc.date.accessioned | 2023-06-12T07:02:49Z | - |
dc.date.available | 2023-06-12T07:02:49Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-06-08T14:41:27Z | - |
dc.identifier.citation | Particle and Fibre Toxicology, 20 (1) (Art N° 20) | - |
dc.identifier.uri | http://hdl.handle.net/1942/40356 | - |
dc.description.abstract | BackgroundAirborne pollution particles have been shown to translocate from the mother's lung to the fetal circulation, but their distribution and internal placental-fetal tissue load remain poorly explored. Here, we investigated the placental-fetal load and distribution of diesel engine exhaust particles during gestation under controlled exposure conditions using a pregnant rabbit model. Pregnant dams were exposed by nose-only inhalation to either clean air (controls) or diluted and filtered diesel engine exhaust (1 mg/m(3)) for 2 h/day, 5 days/week, from gestational day (GD) 3 to GD27. At GD28, placental and fetal tissues (i.e., heart, kidney, liver, lung and gonads) were collected for biometry and to study the presence of carbon particles (CPs) using white light generation by carbonaceous particles under femtosecond pulsed laser illumination.ResultsCPs were detected in the placenta, fetal heart, kidney, liver, lung and gonads in significantly higher amounts in exposed rabbits compared with controls. Through multiple factor analysis, we were able to discriminate the diesel engine exposed pregnant rabbits from the control group taking all variables related to fetoplacental biometry and CP load into consideration. Our findings did not reveal a sex effect, yet a potential interaction effect might be present between exposure and fetal sex.ConclusionsThe results confirmed the translocation of maternally inhaled CPs from diesel engine exhaust to the placenta which could be detected in fetal organs during late-stage pregnancy. The exposed can be clearly discriminated from the control group with respect to fetoplacental biometry and CP load. The differential particle load in the fetal organs may contribute to the effects on fetoplacental biometry and to the malprogramming of the fetal phenotype with long-term effects later in life. | - |
dc.description.sponsorship | The detection equipment was funded by the METHUSALEM Program and the INCALO project (ERC-PoC). The authors acknowledge the Flemish Scientific Research Foundation (FWO; 1150920 N to E.B. and G082317N). Animal exposure and sample collection was supported by ANR grant ANR-13-CESA0011-EPAPP (P.C.P.) and by ERC consolidator grant N°311765–E-DOHaD (PI, R. Slama). The authors thank the Advanced Optical Microscopy Centre (Hasselt University) for their assistance and maintenance of the microscopic instruments. We also thank SAAJ from INRAE (Livestock PhysiologyReproduction and Animal Diets Experimental Facility, https://doi. org/10.17180/MAQZ-V844). | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.rights | The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | - |
dc.subject.other | Airborne pollution | - |
dc.subject.other | Diesel exhaust | - |
dc.subject.other | Gestational exposure | - |
dc.subject.other | Label-free detection | - |
dc.title | Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Nawrot, TS (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg, B-3590 Diepenbeek, Belgium.; Nawrot, TS (corresponding author), Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Kapucijnenvoer 35,Blok D-Box 7001, B-3000 Leuven, Belgium. | - |
dc.description.notes | tim.nawrot@uhasselt.be | - |
local.publisher.place | CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 20 | - |
dc.identifier.doi | 10.1186/s12989-023-00531-z | - |
dc.identifier.pmid | 37202804 | - |
dc.identifier.isi | 000990756500001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Bongaerts, Eva; Nawrot, Tim S.; Wang, Congrong; Bove, Hannelore] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Kapucijnenvoer 35,Blok D-Box 7001, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Ameloot, Marcel] Hasselt Univ, Biomed Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Roeffaers, Maarten B. J.] Katholieke Univ Leuven, Dept Microbial & Mol Syst, 200F-Box 2454,Celestijnenlaan, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Chavatte-Palmer, Pascale; Couturier-Tarrade, Anne] Univ Paris Saclay, UVSQ, INRAE, BREED, F-78350 Jouy En Josas, France. | - |
local.description.affiliation | [Chavatte-Palmer, Pascale; Couturier-Tarrade, Anne] Ecole Natl Vet Alfort, BREED, F-94700 Misons Alfort, France. | - |
local.description.affiliation | [Cassee, Flemming R.] Natl Inst Publ Hlth & Environm, RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands. | - |
local.description.affiliation | [Cassee, Flemming R.] Univ Utrecht, Inst Risk Assessment Sci, Div Toxicol, Utrecht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | BONGAERTS, Eva | - |
item.contributor | NAWROT, Tim | - |
item.contributor | WANG, Congrong | - |
item.contributor | AMELOOT, Marcel | - |
item.contributor | BOVE, Hannelore | - |
item.contributor | Roeffaers, Maarten B. J. | - |
item.contributor | Chavatte-Palmer, Pascale | - |
item.contributor | Couturier-Tarrade, Anne | - |
item.contributor | Cassee, Flemming R. | - |
item.fullcitation | BONGAERTS, Eva; NAWROT, Tim; WANG, Congrong; AMELOOT, Marcel; BOVE, Hannelore; Roeffaers, Maarten B. J.; Chavatte-Palmer, Pascale; Couturier-Tarrade, Anne & Cassee, Flemming R. (2023) Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. In: Particle and Fibre Toxicology, 20 (1) (Art N° 20). | - |
crisitem.journal.issn | 1743-8977 | - |
crisitem.journal.eissn | 1743-8977 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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s12989-023-00531-z.pdf | Published version | 1.92 MB | Adobe PDF | View/Open |
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