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Title: | Attitudes towards booster, testing and isolation, and their impact on COVID-19 response in winter 2022/2023 in France, Belgium, and Italy: a cross-sectional survey and modelling study | Authors: | de Meijere, Giulia Valdano, Eugenio Castellano, Claudio Debin, Marion Kengne-Kuetche, Charly Noel, Harold Weitz, Joshua S. PAOLOTTI, Daniela HERMANS, Lisa HENS, Niel Colizza, Vittoria |
Issue Date: | 2023 | Publisher: | ELSEVIER | Source: | LANCET REGIONAL HEALTH-EUROPE, 28 (Art N° 100614) | Abstract: | Background European countries are focusing on testing, isolation, and boosting strategies to counter the 2022/2023 winter surge due to SARS-CoV-2 Omicron subvariants. However, widespread pandemic fatigue and limited compliance potentially undermine mitigation efforts.Methods To establish a baseline for interventions, we ran a multicountry survey to assess respondents' willingness to receive booster vaccination and comply with testing and isolation mandates. Integrating survey and estimated im-munity data in a branching process epidemic spreading model, we evaluated the effectiveness and costs of current protocols in France, Belgium, and Italy to manage the winter wave.Findings The vast majority of survey participants (N = 4594) was willing to adhere to testing (>91%) and rapid isolation (>88%) across the three countries. Pronounced differences emerged in the declared senior adherence to booster vaccination (73% in France, 94% in Belgium, 86% in Italy). Epidemic model results estimate that testing and isolation protocols would confer significant benefit in reducing transmission (17-24% reduction, from R = 1.6 to R = 1.3 in France and Belgium, to R = 1.2 in Italy) with declared adherence. Achieving a mitigating level similar to the French protocol, the Belgian protocol would require 35% fewer tests (from 1 test to 0.65 test per infected person) and avoid the long isolation periods of the Italian protocol (average of 6 days vs. 11). A cost barrier to test would significantly decrease adherence in France and Belgium, undermining protocols' effectiveness.Interpretation Simpler mandates for isolation may increase awareness and actual compliance, reducing testing costs, without compromising mitigation. High booster vaccination uptake remains key for the control of the winter wave.Funding The European Commission, ANRS-Maladies Infectieuses emergentes, the Agence Nationale de la Recherche, the Chaires Blaise Pascal Program of the ile-de-France region.Copyright (c) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Notes: | Colizza, V (corresponding author), Sorbonne Univ, Inst Pierre Louis Epidemiol & St Publ IPLESP, INSERM, Paris, France.; Colizza, V (corresponding author), Sorbonne Univ, Hop St Antoine S, Inst Pierre Louis Epidemiol & St Publ IPLESP, INSERM, Site Hop St Antoine,27 rue Chaligny, F-75012 Paris, France. vittoria.colizza@inserm.fr |
Keywords: | SARS-CoV-2;Public health;Omicron;Adherence;Isolation;Booster | Document URI: | http://hdl.handle.net/1942/40375 | ISSN: | 2666-7762 | DOI: | 10.1016/j.lanepe.2023.100614 | ISI #: | 000991225300001 | Rights: | 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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