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Title: | Appendiceal Goblet Cell Carcinoma: Role of Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) | Authors: | Gaillard, M. Van Eyken, P. VERSWIJVEL, Geert VAN DER SPEETEN, Kurt |
Issue Date: | 2023 | Publisher: | SPRINGER INDIA | Source: | INDIAN JOURNAL OF SURGICAL ONCOLOGY, 14 (S1), p. 240-249 | Abstract: | Goblet cell carcinoma (GCC) encompasses a separate entity in appendiceal neoplasms with mixed glandular and neuro-endocrine pathological features. GCC mostly presents as an acute appendicitis duo to luminal obstruction or as an incidental finding on the surgical appendectomy specimen. In case of tumour perforation or presence of other risk factors, guidelines suggest additional treatment with a completing right hemicolectomy or cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). We report the case of a 77-year-old male with symptoms of appendicitis for which an appendectomy was performed. The appendix was ruptured during the procedure. There was an incidental finding of GCC on the pathological specimen. Because of possible tumour soiling, the patient received a prophylactic CRS-HIPEC. A literature review was performed to investigate the potential role for CRS-HIPEC as a curative treatment in patients with GCC. GCC of the appendix is an aggressive type of tumour with a high risk of peritoneal and systemic dissemination. CRS and HIPEC is a treatment option: both in a prophylactic setting and in patients with established peritoneal metastases. | Notes: | van der Speeten, K (corresponding author), Ziekenhuis Oost Limburg, Dept Surg Oncol, Schiepse Bos 6, B-3600 Genk, Limburg, Belgium.; van der Speeten, K (corresponding author), Hasselt Univ, Dept Med & Life Sci, Hasselt, Belgium. kurt.vanderspeeten@ZOL.be |
Keywords: | Goblet cell carcinoma;Appendiceal carcinoma;Cytoreductive surgery;HIPEC;Peritoneal metastases | Document URI: | http://hdl.handle.net/1942/40417 | ISSN: | 0975-7651 | e-ISSN: | 0976-6952 | DOI: | 10.1007/s13193-023-01748-2 | ISI #: | 000994613800002 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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