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http://hdl.handle.net/1942/40420
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DC Field | Value | Language |
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dc.contributor.author | DHONT, Sebastiaan | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | MEEKERS, Evelyne | - |
dc.contributor.author | DAUW, Jeroen | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | ter Maaten, Jozine M. | - |
dc.contributor.author | Damman, Kevin | - |
dc.contributor.author | Mebazaa, Alexandre | - |
dc.contributor.author | Filippatos, Gerasimos | - |
dc.contributor.author | Ruschitzka, Frank | - |
dc.contributor.author | Tang, W. H. Wilson | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2023-06-19T09:05:54Z | - |
dc.date.available | 2023-06-19T09:05:54Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-06-16T10:16:48Z | - |
dc.identifier.citation | EUROPEAN JOURNAL OF HEART FAILURE, 25 (8), 1310-1319 | - |
dc.identifier.uri | http://hdl.handle.net/1942/40420 | - |
dc.description.abstract | Aims Acetazolamide, an inhibitor of proximal tubular sodium reabsorption, leads to more effective decongestion in acute heart failure (AHF). It is unknown whether acetazolamide alters serum sodium and potassium levels on top of loop diuretics and if baseline values modify the treatment effect of acetazolamide. Methods and results This is a pre-specified sub-analysis of the ADVOR trial that randomized 519 patients with AHF and volume overload in a 1:1 ratio to intravenous acetazolamide or matching placebo on top of standardized intravenous loop diuretics. Mean potassium and sodium levels at randomization were 4.2 +/- 0.6 and 139 +/- 4 mmol/L in the acetazolamide arm versus 4.2 +/- 0.6 and 140 +/- 4 mmol/L in the placebo arm. Hypokalaemia (<3.5 mmol/L) on admission was present in 44 (9%) patients and hyponatraemia (<= 135 mmol/L) in 82 (16%) patients. After 3 days of treatment, 44 (17%) patients in the acetazolamide arm and 35 (14%) patients in the placebo arm developed hyponatraemia (p = 0.255). Patients randomized to acetazolamide demonstrated a slight decrease in mean potassium levels during decongestion, which was non-significant over time (p = 0.053) and had no significant impact on hypokalaemia incidence (p = 0.061). Severe hypokalaemia (<3.0 mmol/L) occurred in only 7 (1%) patients, similarly distributed between the two treatment arms (p = 0.676). Randomization towards acetazolamide improved decongestive response irrespective of baseline serum sodium and potassium levels. Conclusions Acetazolamide on top of standardized loop diuretic therapy does not lead to clinically important hypokalaemia or hyponatraemia and improves decongestion over the entire range of baseline serum potassium and sodium levels. [GRAPHICS] . | - |
dc.description.sponsorship | This study (KCE-17001) is independent research funded by Belgian HealthCare Knowledge Centre under the KCE Trials Program. The viewsexpressed in this publication are those of the author(s) and not necessarilythose of Belgian Health Care Knowledge Centre which did not influencethe analysis or reporting of the trial.Conflict of interest: none declared | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2023 European Society of Cardiology | - |
dc.subject.other | Acute heart failure | - |
dc.subject.other | Hyponatraemia | - |
dc.subject.other | Hypokalaemia | - |
dc.subject.other | Decongestion | - |
dc.subject.other | Acetazolamide | - |
dc.title | Sodium and potassium changes during decongestion with acetazolamide - a pre-specified analysis from the ADVOR trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1319 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1310 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (corresponding author), Ziekenhuis Oost Limburg AV, Dept Cardiol, B-3600 Genk, Belgium. | - |
dc.description.notes | wilfried.mullens@zol.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/ejhf.2863 | - |
dc.identifier.pmid | 37062871 | - |
dc.identifier.isi | 000985754700001 | - |
dc.contributor.orcid | Dhont, Sebastiaan/0000-0002-5615-3191 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Dhont, Sebastiaan; Martens, Pieter; Meekers, Evelyne; Nijst, Petra; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg AV, Dept Cardiol, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Dhont, Sebastiaan; Meekers, Evelyne; Dauw, Jeroen; Mullens, Wilfried] Hasselt Univ, Diepenbeek, Belgium. | - |
local.description.affiliation | [Martens, Pieter; Tang, W. H. Wilson] Cleveland Clin, Heart Vasc & Thorac Inst, Dept Cardiovasc Med, Cleveland, OH USA. | - |
local.description.affiliation | [Dauw, Jeroen] AZ Sint Lucas, Dept Cardiol, Ghent, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Univ Hosp Brussels, Ctr Cardiovasc Dis, Jette, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Vrije Univ Brussel, Fac Med & Pharm, Jette, Belgium. | - |
local.description.affiliation | [ter Maaten, Jozine M.; Damman, Kevin] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. | - |
local.description.affiliation | [Mebazaa, Alexandre] Univ Paris Cite, AP HP, Inserm MASCOT, Paris, France. | - |
local.description.affiliation | [Filippatos, Gerasimos] Attikon Univ Hosp, Dept Cardiol, Athens, Greece. | - |
local.description.affiliation | [Ruschitzka, Frank] Univ Heart Ctr, Univ Hosp Zurich, Dept Cardiol, Zurich, Switzerland. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | DHONT, Sebastiaan; MARTENS, Pieter; MEEKERS, Evelyne; DAUW, Jeroen; VERBRUGGE, Frederik; NIJST, Petra; ter Maaten, Jozine M.; Damman, Kevin; Mebazaa, Alexandre; Filippatos, Gerasimos; Ruschitzka, Frank; Tang, W. H. Wilson; DUPONT, Matthias & MULLENS, Wilfried (2023) Sodium and potassium changes during decongestion with acetazolamide - a pre-specified analysis from the ADVOR trial. In: EUROPEAN JOURNAL OF HEART FAILURE, 25 (8), 1310-1319. | - |
item.accessRights | Restricted Access | - |
item.contributor | DHONT, Sebastiaan | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | MEEKERS, Evelyne | - |
item.contributor | DAUW, Jeroen | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | NIJST, Petra | - |
item.contributor | ter Maaten, Jozine M. | - |
item.contributor | Damman, Kevin | - |
item.contributor | Mebazaa, Alexandre | - |
item.contributor | Filippatos, Gerasimos | - |
item.contributor | Ruschitzka, Frank | - |
item.contributor | Tang, W. H. Wilson | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
crisitem.journal.issn | 1388-9842 | - |
crisitem.journal.eissn | 1879-0844 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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European J of Heart Fail - 2023 - Dhont.pdf Restricted Access | Published version | 1.26 MB | Adobe PDF | View/Open Request a copy |
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