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http://hdl.handle.net/1942/40425
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DC Field | Value | Language |
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dc.contributor.author | DIERCKX, Tess | - |
dc.contributor.author | VANHERLE, Sam | - |
dc.contributor.author | HAIDAR, Mansour | - |
dc.contributor.author | GRAJCHEN, Elien | - |
dc.contributor.author | MINGNEAU, Fleur | - |
dc.contributor.author | GERVOIS, Pascal | - |
dc.contributor.author | WOLFS, Esther | - |
dc.contributor.author | Bylemans, Dany | - |
dc.contributor.author | Voet, Arnout | - |
dc.contributor.author | Nguyen , Tien | - |
dc.contributor.author | HAMAD, Ibrahim | - |
dc.contributor.author | KLEINEWIETFELD, Markus | - |
dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.date.accessioned | 2023-06-19T11:22:03Z | - |
dc.date.available | 2023-06-19T11:22:03Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2023-06-16T10:06:48Z | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119 (46) (Art N° e2120393119) | - |
dc.identifier.uri | http://hdl.handle.net/1942/40425 | - |
dc.description.abstract | Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Why endogenous repair mechanisms frequently fail in these disorders is poorly understood. However, there is now evidence indicating that this is related to an overly inflammatory microenvironment combined with the intrinsic inability of oligodendrocyte precursor cells (OPCs) to differentiate into mature myelinating cells. Previously, we found that phloretin, a flavonoid abundantly present in apples and strawberries, reduces neuroinflammation by driving macrophages toward an antiinflammatory phenotype. Here, we show that phloretin also markedly stimulates remyelination in ex vivo and in vivo animal models. Improved remyelination was attributed to a direct impact of phloretin on OPC maturation and occurred independently from alterations in microglia function and inflammation. We found, mechanistically, that phloretin acts as a direct ligand for the fatty acid sensing nuclear receptor peroxisome proliferator-activated receptor gamma, thereby promoting the maturation of OPCs. Together, our findings indicate that phloretin has proregenerative properties in central nervous system disorders, with potentially broad implications for the development of therapeutic strategies and dietary interventions aimed at promoting remyelination. | - |
dc.description.sponsorship | This work was supported by the Flemish Fund for Scientific Research (FWO Vlaanderen; G099618, 12J9119N, and 1501720N). M.K. was supported by the European Research Council under the European Union’s Horizon 2020 research and innovation program (640116), by a Salk grant from the government of Flanders, Belgium, and by the FWO (G0G1216N and G080121N) | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.rights | 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) | - |
dc.subject.other | multiple sclerosis | - |
dc.subject.other | oligodendrocyte | - |
dc.subject.other | phloretin | - |
dc.subject.other | remyelination | - |
dc.title | Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 46 | - |
dc.identifier.volume | 119 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | jerome.hendriks@uhasselt.be | - |
local.publisher.place | 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e2120393119 | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 640116 | - |
dc.identifier.doi | 10.1073/pnas.2120393119 | - |
dc.identifier.pmid | 36343243 | - |
dc.identifier.isi | 000995345200002 | - |
dc.contributor.orcid | voet, arnout/0000-0002-3329-2703; Wolfs, Esther/0000-0001-9277-6524; | - |
dc.contributor.orcid | Kleinewietfeld, Markus/0000-0002-2832-3149; Gervois, | - |
dc.contributor.orcid | Pascal/0000-0002-8320-1320; Hendriks, Jerome/0000-0002-7717-8582 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Dierckx, Tess; Vanherle, Sam; Haidar, Mansour; Grajchen, Elien; Mingneau, Fleur; Hamad, Ibrahim; Kleinewietfeld, Markus; Bogie, Jeroen F. J.; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Gervois, Pascal; Wolfs, Esther] Hasselt Univ, Biomed Res Inst, Grp Cardio & Organ Syst, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Bylemans, Dany] Res Stn Fruit Cultivat, B-3800 St Truiden, Belgium. | - |
local.description.affiliation | [Bylemans, Dany] Katholieke Univ Leuven, Dept Biosyst, B-3001 Heverlee, Belgium. | - |
local.description.affiliation | [Voet, Arnout; Nguyen, Tien] Katholieke Univ Leuven, Dept Chem, Lab Biomol Modelling & Design, B-3001 Heverlee, Belgium. | - |
local.description.affiliation | [Hamad, Ibrahim; Kleinewietfeld, Markus] Hasselt Univ, Vlaams Inst Biotechnol (VIB), Lab Translat Immunomodulat, VIB Ctr Inflammat Res, B-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | DIERCKX, Tess; VANHERLE, Sam; HAIDAR, Mansour; GRAJCHEN, Elien; MINGNEAU, Fleur; GERVOIS, Pascal; WOLFS, Esther; Bylemans, Dany; Voet, Arnout; Nguyen , Tien; HAMAD, Ibrahim; KLEINEWIETFELD, Markus; BOGIE, Jeroen & HENDRIKS, Jerome (2022) Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation. In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119 (46) (Art N° e2120393119). | - |
item.accessRights | Open Access | - |
item.contributor | DIERCKX, Tess | - |
item.contributor | VANHERLE, Sam | - |
item.contributor | HAIDAR, Mansour | - |
item.contributor | GRAJCHEN, Elien | - |
item.contributor | MINGNEAU, Fleur | - |
item.contributor | GERVOIS, Pascal | - |
item.contributor | WOLFS, Esther | - |
item.contributor | Bylemans, Dany | - |
item.contributor | Voet, Arnout | - |
item.contributor | Nguyen , Tien | - |
item.contributor | HAMAD, Ibrahim | - |
item.contributor | KLEINEWIETFELD, Markus | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | HENDRIKS, Jerome | - |
crisitem.journal.issn | 0027-8424 | - |
crisitem.journal.eissn | 1091-6490 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation.pdf | Published version | 3.22 MB | Adobe PDF | View/Open |
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