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http://hdl.handle.net/1942/40487
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DC Field | Value | Language |
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dc.contributor.author | VILACA CAVALLARI MACHADO, Felipe | - |
dc.contributor.author | Vogelmeier, Claus F. | - |
dc.contributor.author | Joerres, Rudolf A. | - |
dc.contributor.author | Watz, Henrik | - |
dc.contributor.author | Bals, Robert | - |
dc.contributor.author | Welte, Tobias | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.contributor.author | Alter, Peter | - |
dc.contributor.author | Franssen, Frits M. E. | - |
dc.date.accessioned | 2023-06-27T10:26:34Z | - |
dc.date.available | 2023-06-27T10:26:34Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-06-23T12:48:22Z | - |
dc.identifier.citation | CHEST, 163 (5) , p. 1071 -1083 | - |
dc.identifier.uri | http://hdl.handle.net/1942/40487 | - |
dc.description.abstract | BACKGROUND: Alterations in body composition, including a low fat-free mass index (FFMI), are common in patients with COPD and occur regardless of body weight. RESEARCH QUESTION: Is the impact of low FFMI on exercise capacity, health-related quality of life (HRQL), and systemic inflammation different among patients with COPD stratified in STUDY DESIGN AND METHODS: We analyzed baseline data of patients with COPD from the COPD and Systemic Consequences-Comorbidities Network (COSYCONET) cohort. AssessHRQL, and inflammatory markers. Patients were stratified in underweight, normal weight (NW), preobese, and obese according to BMI and as presenting low, normal, or high FFMI using 25th and 75th percentiles of reference values. Linear mixed models were used to investigate the associations between fat-free mass (FFM) and fat mass with secondary outcomes in each BMI group. RESULTS: Two thousand one hundred thirty-seven patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stages 1-4; 61% men; mean +/- SD age, 65 +/- 8 years; mean +/- SD FEV1, 52.5 +/- 18.8% predicted) were included. The proportions of patients in underweight, NW, preobese, and obese groups were 12.3%, 31.3%, 39.6%, and 16.8%, respectively. The frequency of low FFMI decreased from lower to higher BMI groups (underweight, 81%; NW, 53%; preobese, 42%; and obese, 39%). FFM was associated with the 6MWD in the underweight group, even when adjusting for a broad set of covariates (P < .05). HRQL was not associated with FFM after adjustment for lung function or dyspnea (P > .32). Fat mass was associated with higher systemic inflammation in the NW and preobese groups (P < .05). INTERPRETATION: In patients with COPD with lower weight, such as underweight patients, higher FFMI is associated independently with better exercise capacity. In contrast, in preobese and obese patients with COPD, a higher FFMI was not consistently associated with better outcomes. | - |
dc.description.sponsorship | COSYCONET is supported by the German Federal Ministry of Education and Research (BMBF) Competence Network Asthma and COPD (ASCONET) and is performed in collaboration with the German Center for Lung Research (DZL). The project is funded by the BMBF [Grant 01 GI 0881] and is supported by unrestricted grants from AstraZeneca GmbH, Bayer Schering Pharma AG, Boehringer Ingelheim Pharma GmbH & Co. KG, Chiesi GmbH, GlaxoSmithKline, Grifols Deutschland GmbH, MSD Sharp & Dohme GmbH, Mundipharma GmbH, Novartis Deutschland GmbH, Pfizer Pharma GmbH, Takeda Pharma Vertrieb GmbH & Co. KG, and Teva GmbH for patient investigations and laboratory measurements. F. V. C. M. is financially supported by ZonMW [ERACoSysMed Grant 90030355]. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2022 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved | - |
dc.subject.other | different BMI classi fi cations? | - |
dc.subject.other | ments included lung function | - |
dc.subject.other | bioelectrical impedance analysis | - |
dc.subject.other | 6-min walk distance (6MWD) | - |
dc.subject.other | KEY WORDS | - |
dc.subject.other | body composition | - |
dc.subject.other | COPD | - |
dc.subject.other | exercise tolerance | - |
dc.subject.other | health status | - |
dc.subject.other | systemic in fl ammation | - |
dc.title | Differential Impact of Low Fat-Free Mass in People With COPD Based on BMI Classifications: Results From the COPD and Systemic Consequences-Comorbidities Network | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1083 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1071 | - |
dc.identifier.volume | 163 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Machado, FVC (corresponding author), Ciro, Dept Res & Dev, Horn, Netherlands.; Machado, FVC (corresponding author), Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Resp Med, Med Ctr, Maastricht, Netherlands.; Machado, FVC (corresponding author), Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Agoralaan, Diepenbeek, Belgium. | - |
dc.description.notes | felipe.machado@uhasselt.be | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.chest.2022.11.040 | - |
dc.identifier.pmid | 36470414 | - |
dc.identifier.isi | 001001388900001 | - |
dc.contributor.orcid | Machado, Felipe V. C./0000-0003-1910-7695; Bals, | - |
dc.contributor.orcid | Robert/0000-0002-1472-9535 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Machado, Felipe V. C.; Spruit, Martijn A.; Franssen, Frits M. E.] Ciro, Dept Res & Dev, Horn, Netherlands. | - |
local.description.affiliation | [Machado, Felipe V. C.; Spruit, Martijn A.; Franssen, Frits M. E.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Resp Med, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Machado, Felipe V. C.] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Agoralaan, Diepenbeek, Belgium. | - |
local.description.affiliation | [Vogelmeier, Claus F.; Alter, Peter] Philipps Univ Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany. | - |
local.description.affiliation | [Joerres, Rudolf A.] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Outpatient Clin Occupat Social & Environm M, Comprehens Pneumol Ctr Munich CPC M,German Ctr Lun, Munich, Germany. | - |
local.description.affiliation | [Watz, Henrik] Airway Res Ctr North ARCN, Pulm Res Inst LungenClin Grosshansdorf, German Ctr forLung Res DZL, Grosshansdorf, Germany. | - |
local.description.affiliation | [Bals, Robert] Saarland Univ Hosp, Dept Internal Med Pulmonol Allergol Resp Intens Ca, Homburg, Germany. | - |
local.description.affiliation | [Welte, Tobias] Hannover Med Sch, Dept Pneumol, Hannover, Germany. | - |
local.uhasselt.international | yes | - |
item.fullcitation | VILACA CAVALLARI MACHADO, Felipe; Vogelmeier, Claus F.; Joerres, Rudolf A.; Watz, Henrik; Bals, Robert; Welte, Tobias; SPRUIT, Martijn A.; Alter, Peter & Franssen, Frits M. E. (2023) Differential Impact of Low Fat-Free Mass in People With COPD Based on BMI Classifications: Results From the COPD and Systemic Consequences-Comorbidities Network. In: CHEST, 163 (5) , p. 1071 -1083. | - |
item.fulltext | With Fulltext | - |
item.contributor | VILACA CAVALLARI MACHADO, Felipe | - |
item.contributor | Vogelmeier, Claus F. | - |
item.contributor | Joerres, Rudolf A. | - |
item.contributor | Watz, Henrik | - |
item.contributor | Bals, Robert | - |
item.contributor | Welte, Tobias | - |
item.contributor | SPRUIT, Martijn A. | - |
item.contributor | Alter, Peter | - |
item.contributor | Franssen, Frits M. E. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0012-3692 | - |
crisitem.journal.eissn | 1931-3543 | - |
Appears in Collections: | Research publications |
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Differential Impact of Low Fat-Free Mass in People With COPD Based on BMI Classifications.pdf Restricted Access | Published version | 451.03 kB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf | Peer-reviewed author version | 1.76 MB | Adobe PDF | View/Open |
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