Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/40575
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dc.contributor.authorRASKING, Leen-
dc.contributor.authorKoshy, Priyanka-
dc.contributor.authorBONGAERTS, Eva-
dc.contributor.authorBOVE, Hannelore-
dc.contributor.authorAMELOOT, Marcel-
dc.contributor.authorPLUSQUIN, Michelle-
dc.contributor.authorDe Vusser, Katrien-
dc.contributor.authorNAWROT, Tim-
dc.date.accessioned2023-07-13T11:15:47Z-
dc.date.available2023-07-13T11:15:47Z-
dc.date.issued2023-
dc.date.submitted2023-07-06T13:18:50Z-
dc.identifier.citationENVIRONMENT INTERNATIONAL, 177 (Art N° 107997)-
dc.identifier.urihttp://hdl.handle.net/1942/40575-
dc.description.abstractBackground: Ultrafine particles, including black carbon (BC), can reach the systemic circulation and therefore may distribute to distant organs upon inhalation. The kidneys may be particularly vulnerable to the adverse effects of BC exposure due to their filtration function.Objectives: We hypothesized that BC particles reach the kidneys via the systemic circulation, where the particles may reside in structural components of kidney tissue and impair kidney function. Methods: In kidney biopsies from 25 transplant patients, we visualized BC particles using white light generation under femtosecond-pulsed illumination. The presence of urinary kidney injury molecule-1 (KIM-1) and cystatin c (CysC) were evaluated with ELISA. We assessed the association between internal and external exposure matrices and urinary biomarkers using Pearson correlation and linear regression models.Results: BC particles could be identified in all biopsy samples with a geometric mean (5th, 95th percentile) of 1.80 x 103 (3.65 x 102, 7.50 x 103) particles/mm3 kidney tissue, predominantly observed in the interstitium (100 %) and tubules (80 %), followed by the blood vessels and capillaries (40 %), and the glomerulus (24 %). Independent from covariates and potential confounders, we found that each 10 % higher tissue BC load resulted in 8.24 % (p = 0.03) higher urinary KIM-1. In addition, residential proximity to a major road was inversely associated with urinary CysC (+10 % distance:-4.68 %; p = 0.01) and KIM-1 (+10 % distance:-3.99 %; p < 0.01). Other urinary biomarkers, e.g., the estimated glomerular filtration rate or creatinine clearance showed no significant associations.Discussion and conclusion: Our findings that BC particles accumulate near different structural components of the kidney represent a potential mechanism explaining the detrimental effects of particle air pollution exposure on kidney function. Furthermore, urinary KIM-1 and CysC show potential as air pollution-induced kidney injury biomarkers for taking a first step in addressing the adverse effects BC might exert on kidney function.-
dc.description.sponsorshipThe authors acknowledge funding from the Special Research Fund (BOF) from Hasselt University granted to LR (BOF20DOC15). BOF had no role in the design, conduct, and preparation of the manuscript. The authors want to acknowledge Ms. Van Der Stukken and Mr. Vos for recommendations and input with the statistical analysis. Furthermore, the authors want to thank Ms. J. De Loor for her guidance and aid with collection and transportation of kidney biopsy tissue and urine samples. The authors also thank the centers of the Leuven Collaborative Group for Renal Transplantation, as well as the clinicians, surgeons, nursing staff, and the patients in this study.-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.rights2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).-
dc.subject.otherBlack carbon-
dc.subject.otherFine particulate matter-
dc.subject.otherAir pollution-
dc.subject.otherKidneys-
dc.subject.otherKidney function-
dc.subject.otherKidney transplantation-
dc.titleAmbient black carbon reaches the kidneys-
dc.typeJournal Contribution-
dc.identifier.volume177-
local.bibliographicCitation.jcatA1-
dc.description.notesNawrot, TS (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.-
dc.description.notestim.nawrot@uhasselt.be-
local.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr107997-
dc.identifier.doi10.1016/j.envint.2023.107997-
dc.identifier.pmid37269720-
dc.identifier.isi001012383600001-
dc.contributor.orcidBongaerts, Eva/0000-0001-7963-9824-
local.provider.typewosris-
local.description.affiliation[Rasking, Leen; Bongaerts, Eva; Plusquin, Michelle; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.-
local.description.affiliation[Koshy, Priyanka] Univ Hosp Leuven, Dept Pathol, Leuven, Belgium.-
local.description.affiliation[Bove, Hannelore] Hasselt Univ, Dept Sci, Diepenbeek, Belgium.-
local.description.affiliation[Ameloot, Marcel] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium.-
local.description.affiliation[De Vusser, Katrien] Univ Hosp Leuven, Nephrol & Kidney Transplantat, Leuven, Belgium.-
local.description.affiliation[De Vusser, Katrien] Leuven Univ, Dept Microbiol & Immunol, Leuven, Belgium.-
local.description.affiliation[Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Environm & Hlth Unit, Leuven, Belgium.-
local.description.affiliation[Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.-
local.uhasselt.internationalno-
item.accessRightsOpen Access-
item.fullcitationRASKING, Leen; Koshy, Priyanka; BONGAERTS, Eva; BOVE, Hannelore; AMELOOT, Marcel; PLUSQUIN, Michelle; De Vusser, Katrien & NAWROT, Tim (2023) Ambient black carbon reaches the kidneys. In: ENVIRONMENT INTERNATIONAL, 177 (Art N° 107997).-
item.fulltextWith Fulltext-
item.contributorRASKING, Leen-
item.contributorKoshy, Priyanka-
item.contributorBONGAERTS, Eva-
item.contributorBOVE, Hannelore-
item.contributorAMELOOT, Marcel-
item.contributorPLUSQUIN, Michelle-
item.contributorDe Vusser, Katrien-
item.contributorNAWROT, Tim-
crisitem.journal.issn0160-4120-
crisitem.journal.eissn1873-6750-
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