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Title: | When therapy becomes the source of embolism | Authors: | DHONT, Sebastiaan GUTERMANN, Herbert VAN LIERDE, Johan Verbrugghe, Peter VANDERVOORT, Pieter |
Issue Date: | 2023 | Publisher: | OXFORD UNIV PRESS | Source: | European Heart Journal-Cardiovascular Imaging, | Abstract: | A 74-year-old male presented with recurrent transient ischaemic attacks while on warfarin and clopido-grel therapy. The patient had a history of a patent foramen ovale that had been closed percutaneous-ly 11 years ago using the STARFlex Septal Occluder (NMT Medical, Boston, MA). Magnetic resonance imaging of the brain revealed multiple small cortical infarcts, prompting further investigation. A transoesophageal echocardio-gram revealed an 8 × 10 mm left at-rial (LA) mass located at the posterior wall in the vicinity of the device. A thorough evaluation exposed a device leg fracture (Panels a and b, marked with a red arrow), with the protruding leg impacting on the posterior LA wall during each LA contraction, causing erosion and thrombus formation (Panels a, b, and c, marked with a white arrow). Within a 6-month period, LA thrombus was identified in 1.1% of patients who received the STARFlex device, attributed to incomplete endothelialization, antithrombotic drug therapy regimens, hypercoagulant disorders, residual shunting, and technical failures. Nevertheless, a device leg fracture occurring more than a decade after implantation has not yet been reported. The patient was scheduled for surgery via a minimally invasive thoracoscopic technique. The device was removed, and soft thrombus was identified and successfully extracted from the LA (Panel d). Subsequently, the resulting atrial septal defect was surgically closed. The post-operative course was uneventful. This case highlights the importance of recognizing potential complications associated with long-term implantable devices and emphasizes the necessity for regular monitoring and vigilance. Funding: None declared. Conflict of interest: None declared. | Notes: | Vandervoort, PM (corresponding author), Hosp Oost Limburg, Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium.; Vandervoort, PM (corresponding author), Hasselt Univ, Fac Med & Life Sci, Limburg Clin Res Ctr, Doctoral Sch Med & Life Sci, Hasselt, Belgium. Pieter.Vandervoort@zol.be |
Keywords: | Humans;Embolism;Heart Diseases;Pulmonary Embolism | Document URI: | http://hdl.handle.net/1942/40720 | ISSN: | 2047-2404 | e-ISSN: | 2047-2412 | DOI: | 10.1093/ehjci/jead136 | ISI #: | 001010593800001 | Rights: | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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