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http://hdl.handle.net/1942/40794
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DC Field | Value | Language |
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dc.contributor.author | Bar, Laure | - |
dc.contributor.author | Villanueva, Martin Eduardo | - |
dc.contributor.author | Martin, Claudio | - |
dc.contributor.author | VALENCIA RAMIREZ, Andrea | - |
dc.contributor.author | Goole, Jonathan | - |
dc.contributor.author | RENNER, Frank | - |
dc.contributor.author | LOSADA-PEREZ, Patricia | - |
dc.date.accessioned | 2023-08-29T13:59:01Z | - |
dc.date.available | 2023-08-29T13:59:01Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-08-11T11:51:28Z | - |
dc.identifier.citation | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 664 (Art N° 131125) | - |
dc.identifier.uri | http://hdl.handle.net/1942/40794 | - |
dc.description.abstract | Hybrid lipid bilayers are a particular case of supported lipid bilayers with the two monolayer leaflets composed by different types of molecules. These nanostructures can be produced in a well-controlled array fashion and are suitable for the study of biomembrane-related phenomena via electrochemical or plasmonic sensing. Understanding how the underlying solid surface affects the supported membrane formation and organization is necessary for the potential use of these hybrid platforms in applications for which surfaces are not flat and topographically complex. Here we assess the role of lipid phase, substrate surface energy and topography on the formation and stability of hybrid supported membranes from vesicle precursors using complementary surfacesensitive techniques, namely quartz crystal microbalance with dissipation and atomic force microscopy. The stability of hybrid bilayers against thermal and osmotic changes is evaluated and compared to standard supported lipid bilayers formed onto hydrophilic SiO2. Force spectroscopy measurements reveal an overall weaker lateral organization of hybrid membranes as a result of the underlying self-assembled monolayer being not optimally organized. Hybrid bilayers display a decoupled behavior between the two leaflets when vertically compressed at constant speed. On microcontact printed Au surfaces, hybrid bilayers were formed over printed patches, while surprisingly, supported lipid bilayers were observed on non-patterned Au regions suggesting a non-trivial self-assembled monolayer reorganization when in aqueous environment. | - |
dc.description.sponsorship | P.L.P. acknowledges MIS and HTMSoft projects 40003040 and 40008129 by ‘Fonds de la Recherche Scientifique’ (FNRS). A.V.R. and F. U.R. thank Prof. Andreas Terfort, Goethe-Universit¨ at Frankfurt for providing PDMS stamps and finantial support from FWO Odysseus Program under G0D0115N Project. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2023 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Hybrid lipid bilayers | - |
dc.subject.other | Atomic force microscopy | - |
dc.subject.other | Microcontact printing | - |
dc.subject.other | Self-assembled monolayers | - |
dc.subject.other | Force spectroscopy | - |
dc.subject.other | Quartz crystal microbalance with dissipation | - |
dc.subject.other | Lipid membranes | - |
dc.title | Stability of supported hybrid lipid bilayers on chemically and topographically-modified surfaces | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 664 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Losada-Perez, P (corresponding author), Univ Libre Bruxelles, Dept Phys, Expt Soft Matter & Thermal Phys EST Grp, Blvd Triomphe CP223, B-1050 Brussels, Belgium. | - |
dc.description.notes | patricia.maria.losada.perez@ulb.be | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 131125 | - |
dc.identifier.doi | 10.1016/j.colsurfa.2023.131125 | - |
dc.identifier.isi | 001029984600001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Bar, Laure; Villanueva, Martin Eduardo; Martin, Claudio; Losada-Perez, Patricia] Univ Libre Bruxelles, Dept Phys, Expt Soft Matter & Thermal Phys EST Grp, Blvd Triomphe CP223, B-1050 Brussels, Belgium. | - |
local.description.affiliation | [Ramirez, Andrea Valencia; Renner, Frank Uwe] Hasselt Univ, Inst Mat Res, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Ramirez, Andrea Valencia; Renner, Frank Uwe] IMEC vzw, Div IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Goole, Jonathan] Univ Libre Bruxelles, Lab Pharmaceut & Biopharmaceut, Campus Plaine,CP 207, Blvd Triomphe, B-1050 Brussels, Belgium. | - |
local.uhasselt.international | no | - |
item.accessRights | Embargoed Access | - |
item.fullcitation | Bar, Laure; Villanueva, Martin Eduardo; Martin, Claudio; VALENCIA RAMIREZ, Andrea; Goole, Jonathan; RENNER, Frank & LOSADA-PEREZ, Patricia (2023) Stability of supported hybrid lipid bilayers on chemically and topographically-modified surfaces. In: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 664 (Art N° 131125). | - |
item.embargoEndDate | 2025-05-05 | - |
item.fulltext | With Fulltext | - |
item.contributor | Bar, Laure | - |
item.contributor | Villanueva, Martin Eduardo | - |
item.contributor | Martin, Claudio | - |
item.contributor | VALENCIA RAMIREZ, Andrea | - |
item.contributor | Goole, Jonathan | - |
item.contributor | RENNER, Frank | - |
item.contributor | LOSADA-PEREZ, Patricia | - |
crisitem.journal.issn | 0927-7757 | - |
crisitem.journal.eissn | 1873-4359 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Stability of supported hybrid lipid bilayers on chemically and topographically-modified surfaces.pdf Restricted Access | Published version | 10.73 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf Until 2025-05-05 | Peer-reviewed author version | 5.08 MB | Adobe PDF | View/Open Request a copy |
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