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Title: | Serratus plane block versus standard of care for pain control after totally endoscopic aortic valve replacement: a double-blind, randomized controlled, superiority trial | Authors: | VANDENBRANDE, Jeroen Jamaer, Bob STESSEL, Bjorn van Hilst, Eline CALLEBAUT, Ina Yilmaz, Alaaddin PACKLE, Loren Sermeus, Luc Blanco, Rafael Jalil, Hassanin |
Issue Date: | 2023 | Publisher: | BMJ PUBLISHING GROUP | Source: | REGIONAL ANESTHESIA AND PAIN MEDICINE, | Status: | Early view | Abstract: | Introduction Serratus anterior plane block has been proposed to reduce opioid requirements after minimally invasive cardiac surgery, but high-quality evidence is lacking.Methods This prospective, double-blinded, randomized controlled trial recruited patients undergoing totally endoscopic aortic valve replacement. Patients in the intervention arm received a single-injection serratus anterior plane block on arrival to the intensive care unit added to standard of care. Patients in the control group received routine standard of care, including patient-controlled intravenous analgesia. Primary outcome was piritramide consumption within the first 24 hours after serratus anterior plane block placement. We hypothesized that compared with no block, patients in the intervention arm would consume 25% less opioids.Results Seventy-five patients were analyzed (n=38 in intervention arm, n=37 in control arm). When comparing the serratus anterior plane group with the control group, median 24-hour cumulative opioid use was 9 (IQR 6-19.5) vs 15 (IQR 11.3-23.3) morphine milligram equivalents, respectively (p<0.01). Also, pain scores at 4, 8 and 24 hours were lower in the intervention arm at 4, 8 and 24 hours, respectively.Conclusion Combined deep and superficial single-injection serratus anterior plane block is superior to standard of care in reducing opioid requirements and postoperative pain intensity up to 24 hours after totally endoscopic aortic valve replacement. | Notes: | Vandenbrande, J (corresponding author), Jessa Hosp, Dept Anaesthesiol & Pain Med, Campus Virga Jesse, B-3500 Hasselt, Belgium. jeroen.vandenbrande@jessazh.be |
Keywords: | nerve block;pain;postoperative;analgesia | Document URI: | http://hdl.handle.net/1942/40824 | ISSN: | 1098-7339 | e-ISSN: | 1532-8651 | DOI: | 10.1136/rapm-2023-104439 | ISI #: | 001052164300001 | Rights: | American Society of Regional Anesthesia & Pain Medicine 2023. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, an indication of whether changes were made, and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Serratus plane block versus standard of care for pain control after totally endoscopic aortic valve replacement_ a double-blind, randomized controlled, superiority trial.pdf | Early view | 479.02 kB | Adobe PDF | View/Open |
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