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http://hdl.handle.net/1942/40829
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DC Field | Value | Language |
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dc.contributor.author | GOOSSENS, Juul | - |
dc.contributor.author | VANDENRYT, Thijs | - |
dc.contributor.author | Lowdon, Joseph W. W. | - |
dc.contributor.author | VAN GRINSVEN, Bart | - |
dc.contributor.author | EERSELS, Kasper | - |
dc.contributor.author | DEFERME, Wim | - |
dc.contributor.author | THOELEN, Ronald | - |
dc.date.accessioned | 2023-09-05T06:32:12Z | - |
dc.date.available | 2023-09-05T06:32:12Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-09-04T13:54:28Z | - |
dc.identifier.citation | IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 72 (Art N° 9511209) | - |
dc.identifier.uri | http://hdl.handle.net/1942/40829 | - |
dc.description.abstract | Molecular imprinted polymers (MIPs) are well known for their specific recognition of a wide variety of different analytes. However, the complex immobilization process of MIPs onto sensor electrodes poses a significant challenge. This research introduces a novel approach to enhance the application potential of MIPs by exploiting dye-displacement MIPs. These synthetic receptors can selectively release dye upon exposure to an aqueous target. A disposable and low-cost lab-on-chip cartridge is presented, enabling the MIPs to interact with the target solution for dye displacement. Furthermore, these cartridges are coupled to a portable optical sensor setup that can be used for screening samples in a user-friendly and fast manner. Characterization experiments demonstrate the capability of the spectrometer setup to identify different color dyes and intensities. Finally, a proof-of-application shows the use of our sensing setup for the indirect detection of 2-methoxphenidine (2-MXP) using dye-loaded MIPs, employing a dose-response characterization (4PL). Furthermore, as the dye displacement and sensing principle are universal, this setup holds promise for various other sensing applications, including food quality assessment, environmental testing, and pharmaceutical analysis. | - |
dc.description.sponsorship | This work was supported and funded by the European Union’s Regional Development Fund through the Interreg Va Euregion Meuse Rhine project Food Screening EMR. The authors would like to thank the staff of UHasselt and Makerspace PXL for their technical support. They would also like to thank Sam Motmans for his contribution to the development of the user interface and preliminary experimental work. | - |
dc.language.iso | en | - |
dc.publisher | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | - |
dc.rights | 2023 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. | - |
dc.subject.other | Optical variables measurement | - |
dc.subject.other | Optical sensors | - |
dc.subject.other | Lab-on-a-chip | - |
dc.subject.other | Fluid flow measurement | - |
dc.subject.other | Optical pumping | - |
dc.subject.other | Light emitting diodes | - |
dc.subject.other | Adaptive optics | - |
dc.subject.other | Dye-displacement molecular imprinted polymer (MIP) | - |
dc.subject.other | integrated lab-on-chip cartridge | - |
dc.subject.other | portable spectrometer | - |
dc.title | Design of a Lab-on-Chip Cartridge for the Optical Detection of Small Molecules Based on Dye-Displacement MIPs | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 72 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Goossens, J (corresponding author), Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium.; Goossens, J (corresponding author), IMECvzw, Div IMOMEC, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | juul.goossens@uhasselt.be; thijs.vandenryt@uhasselt.be; | - |
dc.description.notes | joe.lowdon@maastrichtuniversity.nl; | - |
dc.description.notes | bart.vangrinsven@maastrichtuniversity.nl; | - |
dc.description.notes | kasper.eersels@maastrichtuniversity.nl; wim.deferme@uhasselt.be; | - |
dc.description.notes | ronald.thoelen@uhasselt.be | - |
local.publisher.place | 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 9511209 | - |
dc.identifier.doi | 10.1109/TIM.2023.3301040 | - |
dc.identifier.isi | 001049981700008 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Goossens, Juul; Vandenryt, Thijs; Deferme, Wim; Thoelen, Ronald] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Goossens, Juul; Vandenryt, Thijs; Deferme, Wim; Thoelen, Ronald] IMECvzw, Div IMOMEC, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Lowdon, Joseph W. W.; van Grinsven, Bart; Eersels, Kasper] Maastricht Univ, Maastricht Sci Program, NL-6200 Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.embargoEndDate | 2025-08-03 | - |
item.fullcitation | GOOSSENS, Juul; VANDENRYT, Thijs; Lowdon, Joseph W. W.; VAN GRINSVEN, Bart; EERSELS, Kasper; DEFERME, Wim & THOELEN, Ronald (2023) Design of a Lab-on-Chip Cartridge for the Optical Detection of Small Molecules Based on Dye-Displacement MIPs. In: IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 72 (Art N° 9511209). | - |
item.contributor | GOOSSENS, Juul | - |
item.contributor | VANDENRYT, Thijs | - |
item.contributor | Lowdon, Joseph W. W. | - |
item.contributor | VAN GRINSVEN, Bart | - |
item.contributor | EERSELS, Kasper | - |
item.contributor | DEFERME, Wim | - |
item.contributor | THOELEN, Ronald | - |
item.accessRights | Embargoed Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0018-9456 | - |
crisitem.journal.eissn | 1557-9662 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Design of a Lab-on-Chip Cartridge for the Optical Detection of Small Molecules Based on Dye-Displacement MIPs.pdf Restricted Access | Published version | 3.36 MB | Adobe PDF | View/Open Request a copy |
Article_design_of_lab-on-chip (2).pdf Until 2025-08-03 | Peer-reviewed author version | 8.58 MB | Adobe PDF | View/Open Request a copy |
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