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http://hdl.handle.net/1942/40836
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DC Field | Value | Language |
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dc.contributor.author | Rafique, Zubaid | - |
dc.contributor.author | Fortuny, Maria Jose | - |
dc.contributor.author | Kuo, Dick | - |
dc.contributor.author | Szarpak, Lukasz | - |
dc.contributor.author | Llauger, Lluis | - |
dc.contributor.author | Espinosa, Begona | - |
dc.contributor.author | Gil, Victor | - |
dc.contributor.author | Jacob, Javier | - |
dc.contributor.author | Alquezar-Arbe, Aitor | - |
dc.contributor.author | Andueza, Juan Antonio | - |
dc.contributor.author | Garrido, Jose Manuel | - |
dc.contributor.author | Aguirre, Alfons | - |
dc.contributor.author | Alonso, Hector | - |
dc.contributor.author | Fuentes, Marta | - |
dc.contributor.author | Lucas-Imbernon, Francisco Javier | - |
dc.contributor.author | Bibiano, Carlos | - |
dc.contributor.author | Burillo-Putze, Guillermo | - |
dc.contributor.author | Nunez, Julio | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Mueller, Christian | - |
dc.contributor.author | Lopez-Ayala, Pedro | - |
dc.contributor.author | Llorens, Pere | - |
dc.contributor.author | Peacock, Frank | - |
dc.contributor.author | Miro, Oscar | - |
dc.contributor.author | CA-SEMES Research Group, ICA-SEMES Research Group | - |
dc.date.accessioned | 2023-09-06T11:24:35Z | - |
dc.date.available | 2023-09-06T11:24:35Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-08-22T13:23:21Z | - |
dc.identifier.citation | AMERICAN JOURNAL OF EMERGENCY MEDICINE, 70 , p. 1 -9 | - |
dc.identifier.uri | http://hdl.handle.net/1942/40836 | - |
dc.description.abstract | Objective: Both hyperkalemia (HK) and Acute Heart Failure (AHF) are associated with increased short-termmortality, and themanagement of eithermay exacerbate the other. As the relationship betweenHK and AHF is poorly described, our purpose was to determine the relationship between HK and short-term outcomes in Emergency Department (ED) AHF. Methods: The EAHFE Registry enrolls all ED AHF patients from 45 Spanish ED and records in-hospital and postdischarge outcomes. Our primary outcome was all-cause in-hospital death, with secondary outcomes of prolonged hospitalization (>7 days) and 7-day post-discharge adverse events (ED revisit, hospitalization, or death). Associations between serum potassium (sK) and outcomes were explored using logistic regression by restricted cubic spline (RCS) curves, with sK =4.0 mEq/L as the reference, adjusting by age, sex, comorbidities, patient baseline status and chronic treatments. Interaction analyses were performed for the primary outcome. Results: Of 13,606 ED AHF patients, the median (IQR) age was 83 (76-88) years, 54% were women, and the median (IQR) sK was 4.5 mEq/L (4.3-4.9) with a range of 4.0-9.9 mEq/L. In-hospital mortality was 7.7%, with prolonged hospitalization in 35.9%, and a 7-day post-discharge adverse event rate of 8.7%. Adjusted in-hospital mortality increased steadily from sK >= 4.8 (OR = 1.35, 95% CI = 1.01-1.80) to sK = 9.9 (8.41, 3.60-19.6). Nondiabetics with elevated sK had higher odds of death, while chronic treatment with mineralocorticoid-receptor antagonists exhibited a mixed effect. Neither prolonged hospitalization nor post-discharge adverse events was associated with sK. Conclusion: In ED AHF, initial sK>4.8mEq/Lwas independently associated with in-hospitalmortality, suggesting that this cohort may benefit from aggressive HK treatment. (c) 2023 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This study was partially supported by grants from the Instituto de Salud Carlos III supported with funds from the Spanish Ministry of Health and FEDER (PI18/00393). We thank Alícia Díaz for her professionalism in data management. | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.rights | 2023 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Acute heart failure | - |
dc.subject.other | Potassium | - |
dc.subject.other | Outcome | - |
dc.subject.other | Mortality | - |
dc.subject.other | Emergency department | - |
dc.subject.other | Revisit | - |
dc.subject.other | Hospitalization | - |
dc.title | Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 9 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 70 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Rafique, Z (corresponding author), Ben Taub Gen Hosp, Baylor Coll Med, 1504 Ben Taub Loop, Houston, TX 77030 USA. | - |
dc.description.notes | zubaidrafique@gmail.com | - |
local.publisher.place | 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ajem.2023.05.005 | - |
dc.identifier.pmid | 37186977 | - |
dc.identifier.isi | 001035298600001 | - |
dc.contributor.orcid | Herrera, Sergio/0000-0001-6134-0402 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Rafique, Zubaid; Kuo, Dick; Szarpak, Lukasz; Peacock, Frank] Baylor Coll Med, Henry JN Taub Dept Emergency Med, Houston, TX USA. | - |
local.description.affiliation | [Fortuny, Maria Jose] Hosp Gandia, Emergency Dept, Alicante, Spain. | - |
local.description.affiliation | [Llauger, Lluis] Hosp Univ Vic, Emergency Dept, Barcelona, Catalonia, Spain. | - |
local.description.affiliation | [Espinosa, Begona; Llorens, Pere] Univ Miguel Hernandez, Inst Invest Sanitaria & Biomed Alicante ISABIAL, Emergency Short Stay Hospitalizat Home Dept, Hosp Gen Dr Balmis Alicante, Alicante, Spain. | - |
local.description.affiliation | [Gil, Victor; Miro, Oscar] Univ Barcelona, Hosp Clin, IDIBAPS, Emergency Dept, Catalonia, Spain. | - |
local.description.affiliation | [Jacob, Javier] Hosp Univ Bellvitge, Emergency Dept, Barcelona, Catalonia, Spain. | - |
local.description.affiliation | [Alquezar-Arbe, Aitor] Hosp Santa Creu & Sant Pau, Emergency Dept, Barcelona, Catalonia, Spain. | - |
local.description.affiliation | [Andueza, Juan Antonio] Hosp Gen Univ Gregorio Maranon, Emergency Dept, Madrid, Spain. | - |
local.description.affiliation | [Garrido, Jose Manuel] Hosp Virgen Macarena, Emergency Dept, Seville, Spain. | - |
local.description.affiliation | [Aguirre, Alfons] Hosp Mar, Emergency Dept, Barcelona, Catalonia, Spain. | - |
local.description.affiliation | Hosp Univ Salamanca, Emergency Dept, Salamanca, Spain. | - |
local.description.affiliation | Hosp Marques Valdecilla, Emergency Dept, Santander, Spain. | - |
local.description.affiliation | Hosp Gen Univ Albacete, Emergency Dept, Albacete, Spain. | - |
local.description.affiliation | Hosp Infanta Leonor, Emergency Dept, Madrid, Spain. | - |
local.description.affiliation | Hosp Univ Canarias, Santa Cruz De Tenerife, Tenerife, Spain. | - |
local.description.affiliation | Univ Valencia, Hosp Clin Univ Valencia, Ca Cardiol Dept, INCLIVA,CIBER Cardiovasc, Valencia, Spain. | - |
local.description.affiliation | Ziekenhuis Oost Limburg, Cardiol Dept, Genk, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried] Hasselt Univ, Diepenbeek, Belgium. | - |
local.description.affiliation | Univ Hosp Basel, Cardiol Dept, Basel, Switzerland. | - |
local.description.affiliation | [Mueller, Christian; Lopez-Ayala, Pedro] Univ Hosp Basel, Cardiovasc Res Inst Basel CRIB, Basel, Switzerland. | - |
local.description.affiliation | GREAT Global Res Acute Condit Team Network, Rome, Italy. | - |
local.description.affiliation | [Rafique, Zubaid] Ben Taub Gen Hosp, Baylor Coll Med, 1504 Ben Taub Loop, Houston, TX 77030 USA. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Rafique, Zubaid; Fortuny, Maria Jose; Kuo, Dick; Szarpak, Lukasz; Llauger, Lluis; Espinosa, Begona; Gil, Victor; Jacob, Javier; Alquezar-Arbe, Aitor; Andueza, Juan Antonio; Garrido, Jose Manuel; Aguirre, Alfons; Alonso, Hector; Fuentes, Marta; Lucas-Imbernon, Francisco Javier; Bibiano, Carlos; Burillo-Putze, Guillermo; Nunez, Julio; MULLENS, Wilfried; Mueller, Christian; Lopez-Ayala, Pedro; Llorens, Pere; Peacock, Frank; Miro, Oscar & CA-SEMES Research Group, ICA-SEMES Research Group (2023) Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry. In: AMERICAN JOURNAL OF EMERGENCY MEDICINE, 70 , p. 1 -9. | - |
item.contributor | Rafique, Zubaid | - |
item.contributor | Fortuny, Maria Jose | - |
item.contributor | Kuo, Dick | - |
item.contributor | Szarpak, Lukasz | - |
item.contributor | Llauger, Lluis | - |
item.contributor | Espinosa, Begona | - |
item.contributor | Gil, Victor | - |
item.contributor | Jacob, Javier | - |
item.contributor | Alquezar-Arbe, Aitor | - |
item.contributor | Andueza, Juan Antonio | - |
item.contributor | Garrido, Jose Manuel | - |
item.contributor | Aguirre, Alfons | - |
item.contributor | Alonso, Hector | - |
item.contributor | Fuentes, Marta | - |
item.contributor | Lucas-Imbernon, Francisco Javier | - |
item.contributor | Bibiano, Carlos | - |
item.contributor | Burillo-Putze, Guillermo | - |
item.contributor | Nunez, Julio | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Mueller, Christian | - |
item.contributor | Lopez-Ayala, Pedro | - |
item.contributor | Llorens, Pere | - |
item.contributor | Peacock, Frank | - |
item.contributor | Miro, Oscar | - |
item.contributor | CA-SEMES Research Group, ICA-SEMES Research Group | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0735-6757 | - |
crisitem.journal.eissn | 1532-8171 | - |
Appears in Collections: | Research publications |
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Hyperkalemia in acute heart failure_ Short term outcomes from the EAHFE registry.pdf Restricted Access | Published version | 2.87 MB | Adobe PDF | View/Open Request a copy |
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