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http://hdl.handle.net/1942/40876
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DC Field | Value | Language |
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dc.contributor.author | GYSELAERS, Wilfried | - |
dc.date.accessioned | 2023-09-13T11:51:11Z | - |
dc.date.available | 2023-09-13T11:51:11Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-09-13T07:31:44Z | - |
dc.identifier.citation | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 228 (6) , p. 613 -621 | - |
dc.identifier.uri | http://hdl.handle.net/1942/40876 | - |
dc.description.abstract | The importance of uterine microvascular adaptations during placentation in pregnancy has been well established for decades. Inadequate dilatation of spiral arteries is asso-ciated with gestational complications, such as preeclampsia and/or intrauterine growth restriction. More recently, it has become clear that trophoblast cells invade and adapt decidual veins and lymphatic vessels 1 month before spiral arteries become patent and before intervillous space perfusion starts. Normal intervillous space hemodynamics is characterized by high volume flow at low velocity and pressure in the interseptal com-partments surrounding the chorionic villi, hereby facilitating efficient maternal-fetal exchange. In case of shallow decidual vein dilatation, intervillous arterial supply ex-ceeds venous drainage. This will cause congestion in the interseptal compartments with subsequently reduced perfusion and increased pressure. An efficient mechanism to counteract venous congestion and safeguard the viability of the conceptus is by reducing arterial inflow via shallow dilatation of the spiral arteries. This review made the case for intervillous space congestion as an unexplored trigger for inadequate spiral artery dilatation during the placentation process, eventually leading to abnormal systemic circulatory dysfunctions. An abnormal maternal venous function can result from an abnormal maternal immune response to paternal antigens with an imbalanced release of vasoactive mediators or can exist before conception. To get the full picture of abnormal placentation, maternal veins must not be forgotten. | - |
dc.description.sponsorship | This article was written in acknowledgment of Dr Ivo Brosens, one of the author’s teaching professors at Katholieke Universiteit Leuven Medical School and one of the founding fathers of the fundamental obstetrical paradigm on the effect of microvascular changes during placentation on the further course of pregnancy | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.rights | 2022 Elsevier Inc. All rights reserved. | - |
dc.subject.other | decidual lymphatics | - |
dc.subject.other | immune tolerance | - |
dc.subject.other | inflammation | - |
dc.subject.other | intervillous space | - |
dc.subject.other | intrauterine growth restriction | - |
dc.subject.other | maternal hemodynamics | - |
dc.subject.other | maternal venous hemody-namics | - |
dc.subject.other | maternal-fetal exchange | - |
dc.subject.other | placentation | - |
dc.subject.other | preeclampsia | - |
dc.subject.other | spiral artery | - |
dc.subject.other | trophoblast invasion | - |
dc.subject.other | uterine circulation | - |
dc.subject.other | uterine perfusion | - |
dc.subject.other | venous congestion | - |
dc.subject.other | venous hypertension | - |
dc.title | Origins of abnormal placentation: why maternal veins must not be forgotten | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 621 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 613 | - |
dc.identifier.volume | 228 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Gyselaers, W (corresponding author), Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Genk, Belgium.; Gyselaers, W (corresponding author), Hasselt Univ, Fac Med & Life Sci, Dept Physiol, Diepenbeek, Belgium. | - |
dc.description.notes | Wilfried.gyselaers@uhasselt.be | - |
local.publisher.place | 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.ajog.2022.12.014 | - |
dc.identifier.pmid | 36539026 | - |
dc.identifier.isi | 001057500800001 | - |
dc.contributor.orcid | Gyselaers, Wilfried/0000-0002-5778-434X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Gyselaers, Wilfried] Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Genk, Belgium. | - |
local.description.affiliation | [Gyselaers, Wilfried] Hasselt Univ, Fac Med & Life Sci, Dept Physiol, Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | GYSELAERS, Wilfried (2023) Origins of abnormal placentation: why maternal veins must not be forgotten. In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 228 (6) , p. 613 -621. | - |
item.contributor | GYSELAERS, Wilfried | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0002-9378 | - |
crisitem.journal.eissn | 1097-6868 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Origins of abnormal placentation_ why maternal veins must not be forgotten.pdf Restricted Access | Published version | 1.09 MB | Adobe PDF | View/Open Request a copy |
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