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http://hdl.handle.net/1942/40895
Title: | How will demographic change affect the disease burden of future epidemics? | Authors: | MOGELMOSE, Signe Neels, K. Beutels, P. HENS, Niel |
Issue Date: | 2023 | Publisher: | ELSEVIER SCI LTD | Source: | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 130 , p. S113 | Abstract: | on the cobas SARS-CoV-2 assay (Roche) and the Aptima SARS-CoV-2 assay (Hologic). Findings: We demonstrated comparable sensitivity, specificity, and agreement between self-collected nasal and Rhinoswab samples , compared to HCW-collected samples tested using the cobas SARS-CoV-2 and Aptima SARS-CoV-2 assays. In our study the clinical performance of self-collected specimens was comparable to HCW-collected samples, with both self-collect nasal and Rhi-noswab samples resulting in 90-95% sensitivity, and in most cases > 95% specificity. Discussion: Without the availability of samples for NAAT the ability to perform genomic testing is limited, reducing surveillance and public health investigations. We showed that genomic sequencing from self-collected samples can correctly identify the virus lineage and that the main determination of successful ge-nomic testing is a high viral load rather than collection method. Conclusion: These data support self-collection as an accessible method for community testing for COVID-19 and introduces a novel collection device, the Rhinoswab as an alternative to the standard nasal swab. The testing method of self-collection can be expanded from the widely used RATs to NAAT and genomic testing which may inform the management and public health response to the COVID-19 pandemic. | Document URI: | http://hdl.handle.net/1942/40895 | ISSN: | 1201-9712 | e-ISSN: | 1878-3511 | DOI: | 10.1016/j.ijid.2023.04.280 | ISI #: | 001037898500269 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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