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http://hdl.handle.net/1942/41451
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DC Field | Value | Language |
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dc.contributor.author | Pinxterhuis, Tineke H. | - |
dc.contributor.author | Ploumen, Eline H. | - |
dc.contributor.author | Zocca, Paolo | - |
dc.contributor.author | Doggen, Carine J. M. | - |
dc.contributor.author | Schotborgh, Carl E. | - |
dc.contributor.author | Anthonio, Rutger L. | - |
dc.contributor.author | Roguin, Ariel | - |
dc.contributor.author | Danse, Peter W. | - |
dc.contributor.author | BENIT, Edouard | - |
dc.contributor.author | Aminian, Adel | - |
dc.contributor.author | Hartmann, Marc | - |
dc.contributor.author | Linssen, Gerard C. M. | - |
dc.contributor.author | von Birgelen, Clemens | - |
dc.date.accessioned | 2023-10-02T08:04:42Z | - |
dc.date.available | 2023-10-02T08:04:42Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-10-02T07:41:22Z | - |
dc.identifier.citation | Frontiers in Cardiovascular Medicine, 10 (Art N° 1160201) | - |
dc.identifier.uri | http://hdl.handle.net/1942/41451 | - |
dc.description.abstract | Objectives: We assessed differences in risk profile and 3-year outcome between patients undergoing percutaneous coronary intervention (PCI) for premature and non-premature coronary artery disease (CAD).Background The prevalence of CAD increases with age, yet some individuals develop obstructive CAD at younger age.Methods: Among participants in four randomized all-comers PCI trials, without previous coronary revascularization or myocardial infarction (MI), we compared patients with premature (men <50 years; women <55 years) and non-premature CAD. Various clinical endpoints were assessed, including multivariate analyses.Results: Of 6,171 patients, 887 (14.4%) suffered from premature CAD. These patients had fewer risk factors than patients with non-premature CAD, but were more often smokers (60.7% vs. 26.4%) and overweight (76.2% vs. 69.8%). In addition, premature CAD patients presented more often with ST-segment elevation MI and underwent less often treatment of multiple vessels, and calcified or bifurcated lesions. Furthermore, premature CAD patients had a lower all-cause mortality risk (adj.HR: 0.23, 95%-CI: 0.10-0.52; p < 0.001), but target vessel revascularization (adj.HR: 1.63, 95%-CI: 1.18-2.26; p = 0.003) and definite stent thrombosis risks (adj.HR: 2.24, 95%-CI: 1.06-4.72; p = 0.034) were higher. MACE rates showed no statistically significant difference (6.6% vs. 9.4%; adj.HR: 0.86, 95%-CI: 0.65-1.16; p = 0.33)Conclusions: About one out of seven PCI patients was treated for premature CAD. These patients had less complex risk profiles than patients with non-premature CAD; yet, their risk of repeated revascularization and stent thrombosis was higher. As lifetime event risk of patients with premature CAD is known to be particularly high, further efforts should be made to improve modifiable risk factors such as smoking and overweight. | - |
dc.description.sponsorship | The TWENTE I trial was equally funded by Abbott Vascular and Medtronic. The DUTCH PEERS trial was equally funded by Boston Scientific and Medtronic. The BIO-RESORT trial was equally funded by Biotronik, Boston Scientific, and Medtronic. The BIONYX trial was equally funded by Biotronik and Medtronic. | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | 2023 Pinxterhuis, Ploumen, Zocca, Doggen, Schotborgh, Anthonio, Roguin, Danse, Benit, Aminian, Hartmann, Linssen and von Birgelen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | coronary artery disease | - |
dc.subject.other | drug-eluting stent (DES) | - |
dc.subject.other | percutaneous coronary intervention (or PCI) | - |
dc.subject.other | premature coronary artery disease | - |
dc.subject.other | obstructive coronary artery disease | - |
dc.title | Impact of premature coronary artery disease on adverse event risk following first percutaneous coronary intervention | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | von Birgelen, C (corresponding author), Med Spectrum Twente, Dept Cardiol, Thoraxcentrum Twente, Enschede, Netherlands.; von Birgelen, C (corresponding author), Univ Twente, Fac BMS, Tech Med Ctr, Dept Hlth Technol & Serv Res, Enschede, Netherlands. | - |
dc.description.notes | c.vonbirgelen@mst.nl | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 1160201 | - |
dc.identifier.doi | 10.3389/fcvm.2023.1160201 | - |
dc.identifier.pmid | 37745109 | - |
dc.identifier.isi | 001070020100001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Pinxterhuis, Tineke H.; Ploumen, Eline H.; Zocca, Paolo; Hartmann, Marc; von Birgelen, Clemens] Med Spectrum Twente, Dept Cardiol, Thoraxcentrum Twente, Enschede, Netherlands. | - |
local.description.affiliation | [Pinxterhuis, Tineke H.; Ploumen, Eline H.; Doggen, Carine J. M.; von Birgelen, Clemens] Univ Twente, Fac BMS, Tech Med Ctr, Dept Hlth Technol & Serv Res, Enschede, Netherlands. | - |
local.description.affiliation | [Schotborgh, Carl E.] Haga Hosp, Dept Cardiol, The Hague, Netherlands. | - |
local.description.affiliation | [Anthonio, Rutger L.] Scheper Hosp, Dept Cardiol, Treant Zorggroep, Emmen, Netherlands. | - |
local.description.affiliation | [Roguin, Ariel] Inst Technol, Hadera & B Rappaport Fac Med, Hillel Yaffe Med Ctr, Dept Cardiol, Haifa, Israel. | - |
local.description.affiliation | [Danse, Peter W.] Rijnstate Hosp, Dept Cardiol, Arnhem, Netherlands. | - |
local.description.affiliation | [Benit, Edouard] Jessa Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Aminian, Adel] Ctr Hospitalier Univ Charleroi, Dept Cardiol, Charleroi, Belgium. | - |
local.description.affiliation | [Linssen, Gerard C. M.] Ziekenhuisgroep Twente, Dept Cardiol, Hengelo, Netherlands. | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.fullcitation | Pinxterhuis, Tineke H.; Ploumen, Eline H.; Zocca, Paolo; Doggen, Carine J. M.; Schotborgh, Carl E.; Anthonio, Rutger L.; Roguin, Ariel; Danse, Peter W.; BENIT, Edouard; Aminian, Adel; Hartmann, Marc; Linssen, Gerard C. M. & von Birgelen, Clemens (2023) Impact of premature coronary artery disease on adverse event risk following first percutaneous coronary intervention. In: Frontiers in Cardiovascular Medicine, 10 (Art N° 1160201). | - |
item.fulltext | With Fulltext | - |
item.contributor | Pinxterhuis, Tineke H. | - |
item.contributor | Ploumen, Eline H. | - |
item.contributor | Zocca, Paolo | - |
item.contributor | Doggen, Carine J. M. | - |
item.contributor | Schotborgh, Carl E. | - |
item.contributor | Anthonio, Rutger L. | - |
item.contributor | Roguin, Ariel | - |
item.contributor | Danse, Peter W. | - |
item.contributor | BENIT, Edouard | - |
item.contributor | Aminian, Adel | - |
item.contributor | Hartmann, Marc | - |
item.contributor | Linssen, Gerard C. M. | - |
item.contributor | von Birgelen, Clemens | - |
crisitem.journal.issn | 2297-055X | - |
crisitem.journal.eissn | 2297-055X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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fcvm-10-1160201.pdf | Published version | 1.96 MB | Adobe PDF | View/Open |
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