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http://hdl.handle.net/1942/41486
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DC Field | Value | Language |
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dc.contributor.author | De Borre, Marie | - |
dc.contributor.author | Che, Huiwen | - |
dc.contributor.author | Yu, Qian | - |
dc.contributor.author | Lannoo, Lore | - |
dc.contributor.author | De Ridder, Kobe | - |
dc.contributor.author | Vancoillie, Leen | - |
dc.contributor.author | DREESEN, Pauline | - |
dc.contributor.author | Van Den Ackerveken, Mika | - |
dc.contributor.author | Aerden, Mio | - |
dc.contributor.author | Galle, Eva | - |
dc.contributor.author | Breckpot, Jeroen | - |
dc.contributor.author | Van Keirsbilck, Joachim | - |
dc.contributor.author | GYSELAERS, Wilfried | - |
dc.contributor.author | Devriendt, Koen | - |
dc.contributor.author | Vermeesch, Joris Robert | - |
dc.contributor.author | Van Calsteren, Kristel | - |
dc.contributor.author | Thienpont, Bernard | - |
dc.date.accessioned | 2023-10-09T10:11:56Z | - |
dc.date.available | 2023-10-09T10:11:56Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-10-09T09:14:42Z | - |
dc.identifier.citation | NATURE MEDICINE, 29 (9) , p. 2206 -2215 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41486 | - |
dc.description.abstract | Preeclampsia (PE) is a leading cause for peripartal morbidity, especially if developing early in gestation. To enable prophylaxis in the prevention of PE, pregnancies at risk of PE must be identified early-in the first trimester. To identify at-risk pregnancies we profiled methylomes of plasma-derived, cell-free DNA from 498 pregnant women, of whom about one-third developed early-onset PE. We detected DNA methylation differences between control and PE pregnancies that enabled risk stratification at PE diagnosis but also presymptomatically, at around 12 weeks of gestation (range 9-14 weeks). The first-trimester risk prediction model was validated in an external cohort collected from two centers (area under the curve (AUC) = 0.75) and integrated with routinely available maternal risk factors (AUC = 0.85). The combined risk score correctly predicted 72% of patients with early-onset PE at 80% specificity. These preliminary results suggest that cell-free DNA methylation profiling is a promising tool for presymptomatic PE risk assessment, and has the potential to improve treatment and follow-up in the obstetric clinic. | - |
dc.description.sponsorship | We thank T. Van Brussel and D. Lambrechts (VIB, KU Leuven) for help with high-throughput sequencing; the Obstetrics and Gynaecology unit (UZ Leuven) for help with sampling blood and placental tissue; members of the Leuven Center for Human Genetics for cfDNA extraction, storage and supply; the Leuven Genomics Core for sequencing; and all women who agreed to participate. Computing was performed at the Vlaams Supercomputer Center. This study was supported by Research Foundation – Flanders (FWO), grant nos. 1524119 N (to B.T. and J.R.V.), S003422N (to J.R.V. and B.T.) and G0B4822N and G0C7519N (to B.T.); by KU Leuven Bijzonder Onderzoeksfonds, grant no. 3M180296 (to B.T.); and by a KU Leuven C1 grant (to J.R.V. and B.T.). M.D.B. and M.A. are supported by a Research Foundation – Flanders (FWO) fellowship and B.T. by a BOFZAP mandate. | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.rights | The Author(s), under exclusive licence to Springer Nature America, Inc. 2023 | - |
dc.subject.other | Pregnancy | - |
dc.subject.other | Humans | - |
dc.subject.other | Female | - |
dc.subject.other | Epigenome | - |
dc.subject.other | Area Under Curve | - |
dc.subject.other | DNA Methylation | - |
dc.subject.other | Pre-Eclampsia | - |
dc.subject.other | Cell-Free Nucleic Acids | - |
dc.title | Cell-free DNA methylome analysis for early preeclampsia prediction | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2215 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 2206 | - |
dc.identifier.volume | 29 | - |
local.format.pages | 29 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Thienpont, B (corresponding author), Katholieke Univ Leuven, Dept Human Genet, Lab Funct Epigenet, Leuven, Belgium. | - |
dc.description.notes | bernard.thienpont@kuleuven.be | - |
local.publisher.place | HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1038/s41591-023-02510-5 | - |
dc.identifier.pmid | 37640858 | - |
dc.identifier.isi | 001063746200001 | - |
dc.contributor.orcid | Lannoo, Lore/0000-0002-6271-221X; Thienpont, | - |
dc.contributor.orcid | Bernard/0000-0002-8772-6845; Aerden, Mio/0000-0001-5044-2120; Dreesen, | - |
dc.contributor.orcid | Pauline/0000-0003-4165-6121; De Ridder, Kobe/0000-0001-7343-8642; | - |
dc.contributor.orcid | Vermeesch, Joris/0000-0002-3071-1191; Galle, Eva/0000-0001-9276-2552; | - |
dc.contributor.orcid | Che, Huiwen/0000-0002-3651-069X | - |
local.provider.type | wosris | - |
local.description.affiliation | [De Borre, Marie; Che, Huiwen; Yu, Qian; De Ridder, Kobe; Van Den Ackerveken, Mika; Aerden, Mio; Galle, Eva; Thienpont, Bernard] Katholieke Univ Leuven, Dept Human Genet, Lab Funct Epigenet, Leuven, Belgium. | - |
local.description.affiliation | [De Borre, Marie; Vancoillie, Leen; Aerden, Mio; Breckpot, Jeroen; Devriendt, Koen; Vermeesch, Joris Robert] Univ Leuven, Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium. | - |
local.description.affiliation | [Lannoo, Lore; Van Calsteren, Kristel] Univ Hosp Leuven, Dept Obstet & Gynaecol, Leuven, Belgium. | - |
local.description.affiliation | [Dreesen, Pauline] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Van Keirsbilck, Joachim] St Jans Hosp, Dept Obstet & Gynaecol, Brugge, Belgium. | - |
local.description.affiliation | [Gyselaers, Wilfried] Ziekenhuis Oost Limburg, Dept Gynaecol, Genk, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | De Borre, Marie; Che, Huiwen; Yu, Qian; Lannoo, Lore; De Ridder, Kobe; Vancoillie, Leen; DREESEN, Pauline; Van Den Ackerveken, Mika; Aerden, Mio; Galle, Eva; Breckpot, Jeroen; Van Keirsbilck, Joachim; GYSELAERS, Wilfried; Devriendt, Koen; Vermeesch, Joris Robert; Van Calsteren, Kristel & Thienpont, Bernard (2023) Cell-free DNA methylome analysis for early preeclampsia prediction. In: NATURE MEDICINE, 29 (9) , p. 2206 -2215. | - |
item.contributor | De Borre, Marie | - |
item.contributor | Che, Huiwen | - |
item.contributor | Yu, Qian | - |
item.contributor | Lannoo, Lore | - |
item.contributor | De Ridder, Kobe | - |
item.contributor | Vancoillie, Leen | - |
item.contributor | DREESEN, Pauline | - |
item.contributor | Van Den Ackerveken, Mika | - |
item.contributor | Aerden, Mio | - |
item.contributor | Galle, Eva | - |
item.contributor | Breckpot, Jeroen | - |
item.contributor | Van Keirsbilck, Joachim | - |
item.contributor | GYSELAERS, Wilfried | - |
item.contributor | Devriendt, Koen | - |
item.contributor | Vermeesch, Joris Robert | - |
item.contributor | Van Calsteren, Kristel | - |
item.contributor | Thienpont, Bernard | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1078-8956 | - |
crisitem.journal.eissn | 1546-170X | - |
Appears in Collections: | Research publications |
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Cell-free DNA methylome analysis for early preeclampsia prediction.pdf Restricted Access | Published version | 7.99 MB | Adobe PDF | View/Open Request a copy |
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