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http://hdl.handle.net/1942/41512
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DC Field | Value | Language |
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dc.contributor.author | HOUBEN, Sofie | - |
dc.contributor.author | PITET, Louis | - |
dc.date.accessioned | 2023-10-11T13:26:53Z | - |
dc.date.available | 2023-10-11T13:26:53Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-10-11T12:56:21Z | - |
dc.identifier.citation | REACTIVE & FUNCTIONAL POLYMERS, 191 (Art N° 105676) | - |
dc.identifier.uri | http://hdl.handle.net/1942/41512 | - |
dc.description.abstract | Ionically crosslinked alginate hydrogels have been widely studied for application in tissue engineering. Crosslinking of alginates is routinely done by ionic interaction of the carboxyl groups with multivalent anions such as Ca2+ and Fe3+. In more complex hydrogel designs, such as interpenetrating network hydrogels and double network hydrogels, alginates have been combined with other synthetic polymers to benefit from the advantages of both worlds. The effect of different ions on the properties of single network alginate hydrogels and double network poly(acrylamide)/alginate hydrogels have been studied extensively. However, past reports offer less in terms of comparing different crosslinking methods or different salt precursors. Here, we explore the influence of ionic crosslinking strategies used for crosslinking alginate in double network P(AAm)/Alginate hybrid hydrogels. A comparison is made between different calcium-based crosslinking methods, including a two-step method using CaCl2, a one-step method using CaSO4, and a one-step method using the combination of CaCO3 with glucono & delta;-lactone (GDL). Furthermore, the effect of different metal ions is investigated, including Fe3+, Al3+, Ba2+, Sr2+, and Ca2+. Mechanical properties of the resulting gels are analyzed by tensile and compression testing, revealing a strong correlation between preparation protocol, counter-ion identity, and mechanical response. | - |
dc.description.sponsorship | S.H. is grateful for funding from a BOF-OWB mandate under contract BOF19OWB08. L.M.P. is grateful for partial financial support from the Research Foundation-Flanders (FWO) under contract G080020N. The authors are highly appreciative of the support from undergraduate researcher Florence Scavone for generating some key samples for this study. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2023 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Hybrid hydrogels | - |
dc.subject.other | Alginate | - |
dc.subject.other | Ionic crosslinking | - |
dc.subject.other | Tissue engineering | - |
dc.title | Ionic crosslinking strategies for poly(acrylamide) /alginate hybrid hydrogels | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 191 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Pitet, LM (corresponding author), Hasselt Univ, Inst Mat Res Imo Imomec, Adv Funct Polymers AFP Grp, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
dc.description.notes | louis.pitet@uhasselt.be | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 105676 | - |
dc.identifier.doi | 10.1016/j.reactfunctpolym.2023.105676 | - |
dc.identifier.isi | 001050266300001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Houben, Sofie; Pitet, Louis M.] Hasselt Univ, Inst Mat Res Imo Imomec, Adv Funct Polymers AFP Grp, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | HOUBEN, Sofie & PITET, Louis (2023) Ionic crosslinking strategies for poly(acrylamide) /alginate hybrid hydrogels. In: REACTIVE & FUNCTIONAL POLYMERS, 191 (Art N° 105676). | - |
item.contributor | HOUBEN, Sofie | - |
item.contributor | PITET, Louis | - |
crisitem.journal.issn | 1381-5148 | - |
crisitem.journal.eissn | 1873-166X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Ionic crosslinking strategies for poly(acrylamide) _alginate hybrid hydrogels.pdf Restricted Access | Published version | 7.21 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf | Peer-reviewed author version | 2.17 MB | Adobe PDF | View/Open |
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