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http://hdl.handle.net/1942/41604
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DC Field | Value | Language |
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dc.contributor.author | Bislenghi, Gabriele | - |
dc.contributor.author | Van Den Bossch, Julie | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Wolthuis, Albert | - |
dc.contributor.author | Ferrante, Marc | - |
dc.contributor.author | de Hertogh, Gert | - |
dc.contributor.author | Vermeire, Severine | - |
dc.contributor.author | D'Hoore, Andre | - |
dc.date.accessioned | 2023-10-24T11:02:15Z | - |
dc.date.available | 2023-10-24T11:02:15Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-10-24T10:49:29Z | - |
dc.identifier.citation | INFLAMMATORY BOWEL DISEASES, | - |
dc.identifier.uri | http://hdl.handle.net/1942/41604 | - |
dc.description.abstract | Background Very few risk factors for postoperative recurrence (POR) of Crohn's Disease (CD) after ileocecal resection have been identified. The aim of the present study was to verify the association between an a priori defined list of intraoperative macroscopic findings and POR.Methods This was a prospective observational study including patients undergoing primary ileocecal resection for CD. Four intraoperative factors were independently evaluated by 2 surgeons: length of resected ileum, mesentery thickness, presence of areas of serosal fat infiltration, or abnormal serosal vasodilation on normal bowel proximal to the resected bowel. The primary end point was early endoscopic POR at month 6 and defined as modified Rutgeerts score >= i2b. Secondary end points were clinical and surgical recurrence.Results Between September 2020 and November 2022, 83 consecutive patients were included. Early endoscopic recurrence occurred in 45 of 76 patients (59.2%). Clinical and biochemical recurrence occurred in 17.3% (95% confidence interval, [CI], 10.4%-28.0%) and 14.6% of the patients after 12 months. The risk of developing endoscopic and clinical recurrence was 1.127 (95% CI, 0.448;2.834, P = .799) and 0.896 (95% CI, 0.324-2.478, P = .832) when serosal fat infiltration was observed, and 1.388 (95% CI, 0.554-3.476, P = .484), and 1.153 (95% CI, 0.417;3.187, P = .783) when abnormal serosal vasodilation was observed. Similarly, length of the resected bowel and mesentery thickness showed no association with POR. A subgroup analysis on patients who received no postoperative medical prophylaxis did not identify any risk factor for endoscopic POR.Conclusions The macroscopic appearance of the bowel and associated mesentery during surgery does not seem to be predictive of POR after ileocecal resection for CD. Prospective studies investigating risk factors for Crohn's disease recurrence after surgery are scarce. In a prospective cohort of 83 patients undergoing primary ileocecal resection, no association between few intraoperative macroscopic findings and postoperative endoscopic/clinical recurrence was observed. Graphical Abstract | - |
dc.description.sponsorship | Crohn & Colitis Ulcerosa Vereniging (CCV) Grant for the year 2020. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.rights | The Author(s) 2023. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | - |
dc.subject.other | Crohn's disease | - |
dc.subject.other | Crohn's disease | - |
dc.subject.other | ileitis | - |
dc.subject.other | ileitis | - |
dc.subject.other | ileocecal resection | - |
dc.subject.other | ileocecal resection | - |
dc.subject.other | anastomosis | - |
dc.subject.other | anastomosis | - |
dc.subject.other | postoperative recurrence | - |
dc.subject.other | postoperative recurrence | - |
dc.subject.other | Rutgeerts score | - |
dc.subject.other | Rutgeerts score | - |
dc.subject.other | surgery | - |
dc.subject.other | surgery | - |
dc.title | Appearance of the Bowel and Mesentery During Surgery Is Not Predictive of Postoperative Recurrence After Ileocecal Resection for Crohn's Disease: A Prospective Monocentric Study | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bislenghi, G (corresponding author), UZ Leuven, Herestr 49, B-3000 Leuven, Belgium. | - |
dc.description.notes | gabriele.bislenghi@uzleuven.be | - |
local.publisher.place | JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1093/ibd/izad227 | - |
dc.identifier.pmid | 37793044 | - |
dc.identifier.isi | 001078023500001 | - |
dc.contributor.orcid | Wolthuis, Albert/0000-0002-1200-387X; Vermeire, | - |
dc.contributor.orcid | Severine/0000-0001-9942-3019 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Bislenghi, Gabriele; Van Den Bossch, Julie; Wolthuis, Albert; D'Hoore, Andre] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Abdominal Surg, Leuven, Belgium. | - |
local.description.affiliation | [Fieuws, Steffen] Univ KU Leuven, Interuniv Ctr Biostat & Stat Bioinformat, Leuven, Belgium. | - |
local.description.affiliation | [Ferrante, Marc; Vermeire, Severine] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Gastroenterol & Hepatol, Leuven, Belgium. | - |
local.description.affiliation | [de Hertogh, Gert] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Imaging & Pathol Translat Cell & Tissue Res, Leuven, Belgium. | - |
local.description.affiliation | [Ferrante, Marc; Vermeire, Severine] Katholieke Univ Leuven, Dept Chron Dis & Metab, Leuven, Belgium. | - |
local.description.affiliation | [Fieuws, Steffen] Univ Hasselt, Leuven Hasselt, Belgium. | - |
local.description.affiliation | [Bislenghi, Gabriele] UZ Leuven, Herestr 49, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | Bislenghi, Gabriele; Van Den Bossch, Julie; FIEUWS, Steffen; Wolthuis, Albert; Ferrante, Marc; de Hertogh, Gert; Vermeire, Severine & D'Hoore, Andre (2023) Appearance of the Bowel and Mesentery During Surgery Is Not Predictive of Postoperative Recurrence After Ileocecal Resection for Crohn's Disease: A Prospective Monocentric Study. In: INFLAMMATORY BOWEL DISEASES,. | - |
item.contributor | Bislenghi, Gabriele | - |
item.contributor | Van Den Bossch, Julie | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Wolthuis, Albert | - |
item.contributor | Ferrante, Marc | - |
item.contributor | de Hertogh, Gert | - |
item.contributor | Vermeire, Severine | - |
item.contributor | D'Hoore, Andre | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1078-0998 | - |
crisitem.journal.eissn | 1536-4844 | - |
Appears in Collections: | Research publications |
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