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Title: | Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review | Authors: | Borchert, Robin Azevedo, Tiago Badhwar, AmanPreet Bernal, Jose Betts, Matthew BRUFFAERTS, Rose Burkhart, Michael DEWACHTER, Ilse Gellersen, Helena Low, Audrey Lourida, Ilianna Machado, Luiza R. Madan, Christopher Malpetti, Maura Mejia, Jhony Michopoulou, Sofia Munoz-Neira, Carlos Pepys, Jack Peres, Marion Phillips, Veronica Ramanan, Siddharth Tamburin, Stefano M. Tantiangco, Hanz Thakur, Lokendra Tomassini, Alessandro Vipin, Ashwati Tang, Eugene Newby, Danielle Ranson, Janice M. Llewellyn, David J. Veldsman, Michele Rittman, Timothy |
Issue Date: | 2023 | Publisher: | WILEY | Source: | Alzheimers & Dementia, | Status: | Early view | Abstract: | IntroductionArtificial intelligence (AI) and neuroimaging offer new opportunities for diagnosis and prognosis of dementia. MethodsWe systematically reviewed studies reporting AI for neuroimaging in diagnosis and/or prognosis of cognitive neurodegenerative diseases. ResultsA total of 255 studies were identified. Most studies relied on the Alzheimer's Disease Neuroimaging Initiative dataset. Algorithmic classifiers were the most commonly used AI method (48%) and discriminative models performed best for differentiating Alzheimer's disease from controls. The accuracy of algorithms varied with the patient cohort, imaging modalities, and stratifiers used. Few studies performed validation in an independent cohort. DiscussionThe literature has several methodological limitations including lack of sufficient algorithm development descriptions and standard definitions. We make recommendations to improve model validation including addressing key clinical questions, providing sufficient description of AI methods and validating findings in independent datasets. Collaborative approaches between experts in AI and medicine will help achieve the promising potential of AI tools in practice. HighlightsThere has been a rapid expansion in the use of machine learning for diagnosis and prognosis in neurodegenerative diseaseMost studies (71%) relied on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset with no other individual dataset used more than five timesThere has been a recent rise in the use of more complex discriminative models (e.g., neural networks) that performed better than other classifiers for classification of AD vs healthy controlsWe make recommendations to address methodological considerations, addressing key clinical questions, and validationWe also make recommendations for the field more broadly to standardize outcome measures, address gaps in the literature, and monitor sources of bias | Notes: | Borchert, RJ (corresponding author), Univ Cambridge, Dept Clin Neurosci, Herchel Smith Bldg,Forvie Site Robinson Way Cambr, Cambridge CB2 0SZ, England. rb729@medschl.cam.ac.uk |
Keywords: | artificial intelligence (AI);Alzheimer's disease;dementia;machine learning (ML);neurodegenerative diseases;neuroimaging | Document URI: | http://hdl.handle.net/1942/41616 | ISSN: | 1552-5260 | e-ISSN: | 1552-5279 | DOI: | 10.1002/alz.13412 | ISI #: | 001045413900001 | Rights: | 2023 The Authors. Alzheimer’s & Dementia published byWiley Periodicals LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Alzheimer s Dementia - 2023 - Borchert.pdf | Early view | 1.2 MB | Adobe PDF | View/Open |
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