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Title: | Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits | Authors: | Cho, Jennifer Y. VAN HOORNWEDER, Sybren Sege, Christopher T. Antonucci, Michael U. Mcteague, Lisa M. Caulfield, Kevin A. |
Issue Date: | 2023 | Publisher: | FRONTIERS MEDIA SA | Source: | Frontiers in Neural Circuits, 17 (Art N° 1214959) | Abstract: | Background: Electric field (E-field) modeling is a valuable method of elucidating the cortical target engagement from transcranial magnetic stimulation ( TMS) and transcranial electrical stimulation (tES), but it is typically dependent on individual MRI scans. In this study, we systematically tested whether E-field models in template MNI-152 and Ernie scans can reliably approximate group-level E-fields induced in N = 195 individuals across 5 diagnoses (healthy, alcohol use disorder, tobacco use disorder, anxiety, depression). Methods: We computed 788 E-field models using the CHARM-SimNIBS 4.0.0 pipeline with 4 E-field models per participant (motor and prefrontal targets for TMS and tES). We additionally calculated permutation analyses to determine the point of stability of E-fields to assess whether the 152 brains represented in the MNI-152 template is sufficient. Results: Group-level E-fields did not significantly differ between the individual vs. MNI-152 template and Ernie scans for any stimulation modality or location (p > 0.05). However, TMS-induced E-field magnitudes significantly varied by diagnosis; individuals with generalized anxiety had significantly higher prefrontal and motor E-field magnitudes than healthy controls and those with alcohol use disorder and depression (p < 0.001). The point of stability for group-level E-field magnitudes ranged from 42 (motor tES) to 52 participants (prefrontal TMS). Conclusion: MNI-152 and Ernie models reliably estimate group-average TMS and tES-induced E-fields transdiagnostically. The MNI-152 template includes sufficient scans to control for interindividual anatomical differences (i.e., above the point of stability). Taken together, using the MNI-152 and Ernie brains to approximate group-level E-fields is a valid and reliable approach. | Notes: | Caulfield, KA (corresponding author), Med Univ South Carolina, Dept Neurosci, Charleston, SC 29425 USA.; Caulfield, KA (corresponding author), Med Univ South Carolina, Dept Psychiat, Charleston, SC 29425 USA. caulfiel@musc.edu |
Keywords: | TMS;tES;tDCS;non-invasive brain stimulation;electric field (E-field) modeling;finite element method (FEM);MNI-152;template MRI scan | Document URI: | http://hdl.handle.net/1942/41626 | ISSN: | 1662-5110 | e-ISSN: | 1662-5110 | DOI: | 10.3389/fncir.2023.1214959 | ISI #: | 001068408400001 | Rights: | 2023 Cho, Van Hoornweder, Sege, Antonucci, McTeague and Caulfield. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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