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http://hdl.handle.net/1942/41629
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DC Field | Value | Language |
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dc.contributor.author | Hafeez, Shahzad | - |
dc.contributor.author | Decarli, Monize Caiado | - |
dc.contributor.author | Aldana, Agustina | - |
dc.contributor.author | EBRAHIMI, Mahsa | - |
dc.contributor.author | Ruiter, Floor A. A. | - |
dc.contributor.author | Duimel, Hans | - |
dc.contributor.author | van Blitterswijk, Clemens | - |
dc.contributor.author | Moroni, Lorenzo | - |
dc.contributor.author | PITET, Louis | - |
dc.contributor.author | Baker, Matthew B. | - |
dc.date.accessioned | 2023-10-27T07:22:56Z | - |
dc.date.available | 2023-10-27T07:22:56Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-10-26T18:40:11Z | - |
dc.identifier.citation | ADVANCED MATERIALS, 35 (35) (Art N° e2301242) | - |
dc.identifier.uri | http://hdl.handle.net/1942/41629 | - |
dc.description.abstract | Synthetic hydrogels often lack the load-bearing capacity and mechanical properties of native biopolymers found in tissue, such as cartilage. In natural tissues, toughness is often imparted via the combination of fibrous noncovalent self-assembly with key covalent bond formation. This controlled combination of supramolecular and covalent interactions remains difficult to engineer, yet can provide a clear strategy for advanced biomaterials. Here, a synthetic supramolecular/covalent strategy is investigated for creating a tough hydrogel that embodies the hierarchical fibrous architecture of the extracellular matrix (ECM). A benzene-1,3,5-tricarboxamide (BTA) hydrogelator is developed with synthetically addressable norbornene handles that self-assembles to form a and viscoelastic hydrogel. Inspired by collagen's covalent cross-linking of fibrils, the mechanical properties are reinforced by covalent intra- and interfiber cross-links. At over 90% water, the hydrogels withstand up to 550% tensile strain, 90% compressive strain, and dissipated energy with recoverable hysteresis. The hydrogels are shear-thinning, can be 3D bioprinted with good shape fidelity, and can be toughened via covalent cross-linking. These materials enable the bioprinting of human mesenchymal stromal cell (hMSC) spheroids and subsequent differentiation into chondrogenic tissue. Collectively, these findings highlight the power of covalent reinforcement of supramolecular fibers, offering a strategy for the bottom-up design of dynamic, yet tough, hydrogels and bioinks. | - |
dc.description.sponsorship | S.H. and C.v.B. would like to thank the European Research Council (ERC) for funding under the European Union’s Horizons 2020 research and innovation programme (Grant Agreement No. 694801). M.C.D. and L.M. acknowledge the support of the European Union’s Horizon 2020 researchand innovatprogramamme under grant agreement No 953169 (InterLynk). A.A.A., L.M., and M.B.B. would like to thank the support of NWO (Innovation Fund Chemistry, project “DynAM” under project agreement 731.016.202). A.A.A. would like to thank the support of Marie SkłodowskaCurie Individual Fellowships under grant agreement 101028471. F.A.A.R and M.B.B would like to thank RegMedXB for support. A.A, M.E., L.M.P, and M.B.B would like to thank the Research Foundation-Flanders (FWO) under contract G080020N. We would also like to thank V. Lapointe for support in the FRAP measuements for this study. Note: Figure 5 was reset on September 1, 2023, after initial publication online. | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.rights | 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.subject.other | bioprinting | - |
dc.subject.other | covalent capture | - |
dc.subject.other | dynamic hydrogels | - |
dc.subject.other | Supramolecular self-assembly | - |
dc.subject.other | tissue engineering | - |
dc.title | In Situ Covalent Reinforcement of a Benzene-1,3,5-Tricarboxamide Supramolecular Polymer Enables Biomimetic, Tough, and Fibrous Hydrogels and Bioinks | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 35 | - |
dc.identifier.volume | 35 | - |
local.format.pages | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Baker, MB (corresponding author), Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, POB 616, NL-6200 MD Maastricht, Netherlands. | - |
dc.description.notes | m.baker@maastrichtuniversity.nl | - |
local.publisher.place | POSTFACH 101161, 69451 WEINHEIM, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e2301242 | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 953169 | - |
dc.identifier.doi | 10.1002/adma.202301242 | - |
dc.identifier.pmid | 37370137 | - |
dc.identifier.isi | 001039252300001 | - |
dc.contributor.orcid | Decarli, Monize/0000-0002-7100-3394; Pitet, Louis/0000-0002-4733-0707; | - |
dc.contributor.orcid | Aldana, Ana Agustina/0000-0003-4997-7982; Moroni, | - |
dc.contributor.orcid | Lorenzo/0000-0003-1298-6025 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Hafeez, Shahzad; Decarli, Monize Caiado; Aldana, Agustina; Ruiter, Floor A. A.; van Blitterswijk, Clemens; Moroni, Lorenzo; Baker, Matthew B.] Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, POB 616, NL-6200 MD Maastricht, Netherlands. | - |
local.description.affiliation | [Ebrahimi, Mahsa; Pitet, Louis M.] Hasselt Univ, Inst Mat Res IMO, Dept Chem, Adv Funct Polymers Grp, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Ruiter, Floor A. A.] Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Cell Biol Inspired Tissue Engn, POB 616, NL-6200 MD Maastricht, Netherlands. | - |
local.description.affiliation | [Duimel, Hans] Maastricht MultiModal Mol Imaging Inst, POB 616, NL-6200 MD Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Hafeez, Shahzad; Decarli, Monize Caiado; Aldana, Agustina; EBRAHIMI, Mahsa; Ruiter, Floor A. A.; Duimel, Hans; van Blitterswijk, Clemens; Moroni, Lorenzo; PITET, Louis & Baker, Matthew B. (2023) In Situ Covalent Reinforcement of a Benzene-1,3,5-Tricarboxamide Supramolecular Polymer Enables Biomimetic, Tough, and Fibrous Hydrogels and Bioinks. In: ADVANCED MATERIALS, 35 (35) (Art N° e2301242). | - |
item.contributor | Hafeez, Shahzad | - |
item.contributor | Decarli, Monize Caiado | - |
item.contributor | Aldana, Agustina | - |
item.contributor | EBRAHIMI, Mahsa | - |
item.contributor | Ruiter, Floor A. A. | - |
item.contributor | Duimel, Hans | - |
item.contributor | van Blitterswijk, Clemens | - |
item.contributor | Moroni, Lorenzo | - |
item.contributor | PITET, Louis | - |
item.contributor | Baker, Matthew B. | - |
crisitem.journal.issn | 0935-9648 | - |
crisitem.journal.eissn | 1521-4095 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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In Situ Covalent Reinforcement of a Benzene‐1,3,5‐Tricarboxamide Supramolecular.pdf | Published version | 5.11 MB | Adobe PDF | View/Open |
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