Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/41641
Title: | Mini-review: Enteric glial cell heterogeneity: Is it all about the niche? | Authors: | SANCHINI, Gabriele VAES, Nathalie BOESMANS, Werend |
Issue Date: | 2023 | Publisher: | ELSEVIER IRELAND LTD | Source: | NEUROSCIENCE LETTERS, 812 (Art N° 137396) | Abstract: | Enteric glial cells represent the enteric population of peripheral glia. According to their 'glial' nature, their principal function is to support enteric neurons in both structural and functional ways. Mounting evidence however demonstrates that enteric glial cells crucially contribute to the majority of enteric nervous system functions, thus acting as pivotal players in the maintenance of gut homeostasis. Various types of enteric glia are present within the gut wall, creating an intricate interaction network with other gastrointestinal cell types. Their distribution throughout the different layers of the gut wall translates in characteristic phenotypes that are tailored to the local tissue requirements of the digestive tract. This heterogeneity is assumed to be mirrored by functional specialization, but the extensive plasticity and versatility of enteric glial cells complicates a one on one phenotype/function definition. Moreover, the relative contribution of niche-specific signals versus lineage determinants for driving enteric glial heterogeneity is still uncertain. In this review we focus on the current understanding of phenotypic and functional enteric glial cell heterogeneity, from a microenvironmental and developmental perspective. | Notes: | Boesmans, W (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Campus Diepenbeek,Agoralaan Gebouw C, B-3590 Diepenbeek, Belgium. werend.boesmans@uhasselt.be |
Keywords: | Cellular plasticity;Enteric nervous system;Gastrointestinal;Neural crest;Neurogenic;Schwann cell precursors | Document URI: | http://hdl.handle.net/1942/41641 | ISSN: | 0304-3940 | e-ISSN: | 1872-7972 | DOI: | 10.1016/j.neulet.2023.137396 | ISI #: | 001041781100001 | Rights: | 2023 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Mini-review_ Enteric glial cell heterogeneity_ Is it all about the niche_.pdf Restricted Access | Published version | 1.42 MB | Adobe PDF | View/Open Request a copy |
Sanchini et al_NSL_Mini-Review_R1_230626_plain text.docx.pdf | Peer-reviewed author version | 539.65 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.