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Title: | Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium | Authors: | Capodanno, Davide Mehran, Roxana Krucoff, Mitchell W. Baber, Usman Bhatt, Deepak L. Capranzano, Piera Collet, Jean-Philippe Cuisset, Thomas De Luca, Giuseppe De Luca, Leonardo Farb, Andrew Franchi, Francesco Gibson, C. Michael Hahn, Joo-Yong Hong, Myeong-Ki James, Stefan Kastrati, Adnan Kimura, Takeshi Lemos, Pedro A. Lopes, Renato D. Magee, Adrian Matsumura, Ryosuke Mochizuki, Shuichi O'Donoghue, Michelle L. Pereira, Naveen L. Rao, Sunil V. Rollini, Fabiana Shirai, Yuko Sibbing, Dirk Smits, Peter C. Steg, P. Gabriel Storey, Robert F. ten Berg, Jurrien Valgimigli, Marco VRANCKX, Pascal Watanabe, Hirotoshi Windecker, Stephan Serruys, Patrick W. Yeh, Robert W. Morice, Marie-Claude Angiolillo, Dominick J. |
Issue Date: | 2023 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | CIRCULATION, 147 (25) , p. 1933 -1944 | Abstract: | Antiplatelet therapy is the mainstay of pharmacologic treatment to prevent thrombotic or ischemic events in patients with coronary artery disease treated with percutaneous coronary intervention and those treated medically for an acute coronary syndrome. The use of antiplatelet therapy comes at the expense of an increased risk of bleeding complications. Defining the optimal intensity of platelet inhibition according to the clinical presentation of atherosclerotic cardiovascular disease and individual patient factors is a clinical challenge. Modulation of antiplatelet therapy is a medical action that is frequently performed to balance the risk of thrombotic or ischemic events and the risk of bleeding. This aim may be achieved by reducing (ie, de-escalation) or increasing (ie, escalation) the intensity of platelet inhibition by changing the type, dose, or number of antiplatelet drugs. Because de-escalation or escalation can be achieved in different ways, with a number of emerging approaches, confusion arises with terminologies that are often used interchangeably. To address this issue, this Academic Research Consortium collaboration provides an overview and definitions of different strategies of antiplatelet therapy modulation for patients with coronary artery disease, including but not limited to those undergoing percutaneous coronary intervention, and consensus statements on standardized definitions. | Notes: | Angiolillo, DJ (corresponding author), Univ Florida, Coll Med Jacksonville, 655 West 8th St, Jacksonville, FL 32209 USA. dcapodanno@gmail.com; roxana.mehran@mountsinai.org; mitchell.krucoff@dm.duke.edu; Usman-Baber@ouhsc.edu; Deepak.Bhatt@mountsinai.org; pcapranzano@gmail.com; jean-philippe.collet@psl.aphp.fr; Thomas.CUISSET@ap-hm.fr; leo.deluca@libero.it; leo.deluca@libero.it; andrew.farb@fda.hhs.gov; francesco.franchi@jax.ufl.edu; charlesmichaelgibson@gmail.com; jyhahn@skku.edu; mkhong61@yuhs.ac; stefan.james@ucr.uu.se; kastrati@dhm.mhn.de; taketaka@kuhp.kyoto-u.ac.jp; pedro.lemos@atscien.com; renato.lopes@duke.edu; Patrick.Magee@fda.hhs.gov; ryosuke.matsumura.d1@tohoku.ac.jp; mochizuki-shuichi2@pmda.go.jp; modonoghue@partners.org; pereira.naveen@mayo.edu; rao00010@gmail.com; Fabiana.Rollini@jax.ufl.edu; shirai-yuko@pmda.go.jp; Dirk.Sibbing@med.uni-muenchen.de; smitsp@maasstadziekenhuis.nl; gabriel.steg@aphp.fr; r.f.storey@sheffield.ac.uk; jurtenberg@gmail.com; vlgmrc@unife.it; pascal.vranckx@iccuhasselt.be; hwatanab@kuhp.kyoto-u.ac.jp; Stephan.Windecker@insel.ch; patrick.w.j.c.serruys@gmail.com; ryeh@bidmc.harvard.edu; mc.morice@icps.com.fr; dominick.angiolillo@jax.ufl.edu |
Keywords: | acute coronary syndrome;coronary artery disease;percutaneous coronary intervention;therapeutics | Document URI: | http://hdl.handle.net/1942/41675 | ISSN: | 0009-7322 | e-ISSN: | 1524-4539 | DOI: | 10.1161/CIRCULATIONAHA.123.064473 | ISI #: | 001009898700007 | Rights: | 2023 American Heart Association, Inc | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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