Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/41685
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dc.contributor.authorLi, Kan Yan Chloe-
dc.contributor.authorDejea, Hector-
dc.contributor.authorDe Winne, Koen-
dc.contributor.authorBonnin, Anne-
dc.contributor.authorD'ONOFRIO, Valentino-
dc.contributor.authorCOX, Janneke-
dc.contributor.authorGarcia-Canadilla, Patricia-
dc.contributor.authorLammens, Martin-
dc.contributor.authorCook, Andrew C.-
dc.contributor.authorBijnens, Bart-
dc.contributor.authorDendooven, Amelie-
dc.date.accessioned2023-11-08T09:27:15Z-
dc.date.available2023-11-08T09:27:15Z-
dc.date.issued2023-
dc.date.submitted2023-11-01T13:03:41Z-
dc.identifier.citationHISTOCHEMISTRY AND CELL BIOLOGY, 160 (5) , p. 377 -389-
dc.identifier.urihttp://hdl.handle.net/1942/41685-
dc.description.abstractX-ray phase contrast imaging (X-PCI) is a powerful technique for high-resolution, three-dimensional imaging of soft tissue samples in a non-destructive manner. In this technical report, we assess the quality of standard histopathological techniques performed on formalin-fixed, paraffin-embedded (FFPE) human tissue samples that have been irradiated with different doses of X-rays in the context of an X-PCI experiment. The data from this study demonstrate that routine histochemical and immunohistochemical staining quality as well as DNA and RNA analyses are not affected by previous X-PCI on human FFPE samples. From these data we conclude it is feasible and acceptable to perform X-PCI on FFPE human biopsies.-
dc.description.sponsorshipThis project was supported by the grant #2017‐303 of the Strategic Focal Area “Personalized Health and Related Technologies (PHRT)” of the ETH Domain. The study has also received funding from the Research Foundation Flanders (FWO), grant G0G2620N. PGC received funding from the postdoctoral fellowships program Beatriu de Pinos (2018-BP-00201), funded by Secretary of Universities and Research (Government of Catalonia) and Horizon 2020 program of research and innovation of the European Union under the Marie Skłodowska-Curie Grant Agreement No. 801370. BB received funding from the Clinical Research in Cardiology of the Spanish Foundation of the Heart grant from the Spanish Cardiac Society (SEC/FEC- INV-CLI 20/028). KYCL received funding from the British Heart Foundation as (Grant No. BHF FS/4yPhD/F/20/34134). We acknowledge the Paul Scherrer Institut, Villigen, Switzerland, for provision of synchrotron radiation beamtime at beamline TOMCAT of the SLS. We thank Dr. Ruth Achten (Jessa Hospital) for kind assistance.-
dc.language.isoen-
dc.publisherSPRINGER-
dc.rightsThe Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023-
dc.subject.otherX-ray phase contrast imaging-
dc.subject.otherPathology-
dc.subject.otherNeedle biopsies-
dc.titleFeasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis-
dc.typeJournal Contribution-
dc.identifier.epage389-
dc.identifier.issue5-
dc.identifier.spage377-
dc.identifier.volume160-
local.format.pages13-
local.bibliographicCitation.jcatA1-
dc.description.notesDendooven, A (corresponding author), Antwerp Univ Hosp, Univ Antwerp, Dept Pathol, Antwerp, Belgium.; Dendooven, A (corresponding author), Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium.-
dc.description.notesAmelie.dendooven@uzgent.be-
local.publisher.placeONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.type.programmeH2020-
local.relation.h2020801370-
dc.identifier.doi10.1007/s00418-023-02220-6-
dc.identifier.pmid37523091-
dc.identifier.isi001040154200001-
dc.contributor.orcidLammens, Martin/0000-0002-3881-6692; Li, Kan Yan-
dc.contributor.orcidChloe/0000-0001-7737-2118; Garcia-Canadilla,-
dc.contributor.orcidPatricia/0000-0002-0223-1617; Dejea, Hector/0000-0003-2584-9812;-
dc.contributor.orcidD'Onofrio, Valentino/0000-0003-3828-0442; Bijnens,-
dc.contributor.orcidBart/0000-0003-3130-6937-
local.provider.typewosris-
local.description.affiliation[Li, Kan Yan Chloe; Cook, Andrew C.] UCL, Inst Cardiovasc Sci, London, England.-
local.description.affiliation[Dejea, Hector; Bonnin, Anne] Paul Scherrer Inst, Swiss Light Source, Villigen, Switzerland.-
local.description.affiliation[Dejea, Hector] Swiss Fed Inst Technol, Zurich, Switzerland.-
local.description.affiliation[Dejea, Hector] Lund Univ, Dept Biomed Engn, Lund, Sweden.-
local.description.affiliation[Dejea, Hector] MAX IV Lab, Lund, Sweden.-
local.description.affiliation[De Winne, Koen; Lammens, Martin; Dendooven, Amelie] Antwerp Univ Hosp, Univ Antwerp, Dept Pathol, Antwerp, Belgium.-
local.description.affiliation[D'Onofrio, Valentino; Cox, Janneke A.; Dendooven, Amelie] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium.-
local.description.affiliation[Cox, Janneke A.] Jessa Hosp, Dept Infect Dis & Immun, Hasselt, Belgium.-
local.description.affiliation[Garcia-Canadilla, Patricia] St Joan Deu Res Inst IRSJD, Interdisciplinary Cardiovasc Res Grp, Barcelona, Spain.-
local.description.affiliation[Garcia-Canadilla, Patricia] Univ Barcelona, Hosp Sant Joan Deu, BCNatal Barcelona Ctr Maternal Fetal & Neonatal Me, Barcelona, Spain.-
local.description.affiliation[Garcia-Canadilla, Patricia] Univ Barcelona, Hosp Clin, Barcelona, Spain.-
local.description.affiliationICREA, Barcelona, Spain.-
local.description.affiliationIDIBAPS, Barcelona, Spain.-
local.uhasselt.internationalyes-
item.fullcitationLi, Kan Yan Chloe; Dejea, Hector; De Winne, Koen; Bonnin, Anne; D'ONOFRIO, Valentino; COX, Janneke; Garcia-Canadilla, Patricia; Lammens, Martin; Cook, Andrew C.; Bijnens, Bart & Dendooven, Amelie (2023) Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis. In: HISTOCHEMISTRY AND CELL BIOLOGY, 160 (5) , p. 377 -389.-
item.contributorLi, Kan Yan Chloe-
item.contributorDejea, Hector-
item.contributorDe Winne, Koen-
item.contributorBonnin, Anne-
item.contributorD'ONOFRIO, Valentino-
item.contributorCOX, Janneke-
item.contributorGarcia-Canadilla, Patricia-
item.contributorLammens, Martin-
item.contributorCook, Andrew C.-
item.contributorBijnens, Bart-
item.contributorDendooven, Amelie-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
crisitem.journal.issn0948-6143-
crisitem.journal.eissn1432-119X-
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