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http://hdl.handle.net/1942/41747
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DC Field | Value | Language |
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dc.contributor.author | Moreel, Lien | - |
dc.contributor.author | Coudyzer, Walter | - |
dc.contributor.author | Boeckxstaens, Lennert | - |
dc.contributor.author | Betrains, Albrecht | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Vanderschueren, Steven | - |
dc.contributor.author | Claus, Eveline | - |
dc.contributor.author | Van Laere, Koen | - |
dc.contributor.author | Blockmans, Daniel | - |
dc.date.accessioned | 2023-11-13T09:15:56Z | - |
dc.date.available | 2023-11-13T09:15:56Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-11-13T09:08:36Z | - |
dc.identifier.citation | ANNALS OF INTERNAL MEDICINE, 176 (10) , p. 1321 -1329 | - |
dc.identifier.issn | 0003-4819 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41747 | - |
dc.description.abstract | Background: Previous studies have shown that patients with giant cell arteritis (GCA) who have vascular F-18-fluorodeoxyglucose (FDG) uptake at diagnosis are at increased risk for thoracic aortic complications.Objective: To measure the association between vascular FDG uptake at diagnosis and the change in aortic dimensions.Design: Prospective cohort study.Setting: University Hospitals Leuven.Patients: 106 patients with GCA and FDG positron emission tomography (PET) imaging 3 days or less after initiation of glucocorticoids.Measurements: Patients had PET and computed tomography (CT) imaging at diagnosis and CT imaging yearly for a maximum of 10 years. The PET scans were scored 0 to 3 in 7 vascular areas and summed to a total vascular score (TVS). The PET scan results were positive when FDG uptake was grade 2 or greater in any large vessel. The association between vascular FDG uptake and aortic dimensions was estimated by linear mixed-effects models with random intercept and slope.Results: When compared with patients with a negative PET scan result, those with a positive scan result had a greater increase in the diameter of the ascending aorta (difference in 5-year progression, 1.58 mm [95% CI, 0.41 to 2.74 mm]), the diameter of the descending aorta (1.32 mm [CI, 0.38 to 2.26 mm]), and the volume of the thoracic aorta (20.5 cm(3) [CI, 4.5 to 36.5 cm(3)]). These thoracic aortic dimensions were also positively associated with TVS. Patients with a positive PET scan result had a higher risk for thoracic aortic aneurysms (adjusted hazard ratio, 10.21 [CI, 1.25 to 83.3]).Limitation: The lengthy inclusion and follow-up period resulted in missing data and the use of different PET machines.Conclusion: Higher TVS was associated with greater yearly increase in thoracic aortic dimensions. Performing PET imaging at diagnosis may help to estimate the risk for aortic aneurysm formation.Primary Funding Source: None. | - |
dc.description.sponsorship | Disclosures can be viewed at www.acponline.org/ authors/icmje/ConflictOfInterestForms.do?msNum¼M23-0679. | - |
dc.language.iso | en | - |
dc.publisher | AMER COLL PHYSICIANS | - |
dc.rights | 2023 American College of Physicians | - |
dc.subject.other | Humans | - |
dc.subject.other | Cohort Studies | - |
dc.subject.other | Prospective Studies | - |
dc.subject.other | Positron-Emission Tomography | - |
dc.subject.other | Fluorodeoxyglucose F18 | - |
dc.subject.other | Giant Cell Arteritis | - |
dc.title | Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis: A Cohort Study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1329 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1321 | - |
dc.identifier.volume | 176 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Blockmans, D (corresponding author), Univ Hosp Leuven, Dept Gen Internal Med, Herestr 49, B-3000 Leuven, Belgium. | - |
dc.description.notes | Daniel.Blockmans@uzleuven.be | - |
local.publisher.place | INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572, UNITED STATES | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.7326/M23-0679 | - |
dc.identifier.pmid | 37782924 | - |
dc.identifier.isi | 001081890100001 | - |
dc.contributor.orcid | Claus, Eveline/0000-0003-0975-0636; Molenberghs, | - |
dc.contributor.orcid | Geert/0000-0002-6453-5448; Moreel, Lien/0000-0002-7613-4801 | - |
dc.identifier.eissn | 1539-3704 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Moreel, Lien; Betrains, Albrecht] Univ Hosp Leuven, Dept Gen Internal Med, Leuven, Belgium. | - |
local.description.affiliation | [Moreel, Lien; Betrains, Albrecht] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Coudyzer, Walter; Claus, Eveline] Univ Hosp Leuven, Dept Radiol, Leuven, Belgium. | - |
local.description.affiliation | [Boeckxstaens, Lennert] Univ Hosp Leuven, Dept Nucl Med, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. | - |
local.description.affiliation | [Vanderschueren, Steven; Blockmans, Daniel] Univ Hosp Leuven, Dept Gen Internal Med, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Vanderschueren, Steven; Blockmans, Daniel] ERN, RITA, Leuven, Belgium. | - |
local.description.affiliation | [Van Laere, Koen] Univ Leuven, KU Leuven, Dept Imaging & Pathol Nucl Med & Mol Imaging, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Blockmans, Daniel] Univ Hosp Leuven, Dept Gen Internal Med, Herestr 49, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Moreel, Lien; Coudyzer, Walter; Boeckxstaens, Lennert; Betrains, Albrecht; MOLENBERGHS, Geert; Vanderschueren, Steven; Claus, Eveline; Van Laere, Koen & Blockmans, Daniel (2023) Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis: A Cohort Study. In: ANNALS OF INTERNAL MEDICINE, 176 (10) , p. 1321 -1329. | - |
item.accessRights | Open Access | - |
item.contributor | Moreel, Lien | - |
item.contributor | Coudyzer, Walter | - |
item.contributor | Boeckxstaens, Lennert | - |
item.contributor | Betrains, Albrecht | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Vanderschueren, Steven | - |
item.contributor | Claus, Eveline | - |
item.contributor | Van Laere, Koen | - |
item.contributor | Blockmans, Daniel | - |
crisitem.journal.issn | 0003-4819 | - |
crisitem.journal.eissn | 1539-3704 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis.pdf Restricted Access | Published version | 344.64 kB | Adobe PDF | View/Open Request a copy |
ACFrOgB7IfacDBe7Tvs5gL219SJtn4.pdf | Peer-reviewed author version | 717.49 kB | Adobe PDF | View/Open |
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