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http://hdl.handle.net/1942/41761
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DC Field | Value | Language |
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dc.contributor.author | Deniau, Benjamin | - |
dc.contributor.author | Costanzo, Maria Rosa | - |
dc.contributor.author | Sliwa, Karen | - |
dc.contributor.author | Asakage, Ayu | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Mebazaa, Alexandre | - |
dc.date.accessioned | 2023-11-13T14:51:05Z | - |
dc.date.available | 2023-11-13T14:51:05Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-11-13T14:15:27Z | - |
dc.identifier.citation | EUROPEAN HEART JOURNAL, 44, p. 4634–4649 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41761 | - |
dc.description.abstract | Acute heart failure (AHF) represents the most frequent cause of unplanned hospital admission in patients older than 65 years. Symptoms and clinical signs of AHF (e.g. dyspnoea, orthopnoea, oedema, jugular vein distension, and variation of body weight) are mostly related to systemic venous congestion secondary to various mechanisms including extracellular fluids, increased ventricular filling pressures, and/or auto-transfusion of blood from the splanchnic into the pulmonary circulation. Thus, the initial management of AHF patients should be mostly based on decongestive therapies on admission followed, before discharge, by rapid implementation of guideline-directed oral medical therapies for heart failure. The therapeutic management of AHF requires the identification and rapid diagnosis of the disease, the diagnosis of the cause (or triggering factor), the evaluation of severity, the presence of comorbidities, and, finally, the initiation of a rapid treatment. The most recent guidelines from ESC and ACC/AHA/HFSA have provided updated recommendations on AHF management. Recommended pharmacological treatment for AHF includes diuretic therapy aiming to relieve congestion and achieve optimal fluid status, early and rapid initiation of oral therapies before discharge combined with a close follow-up. Non-pharmacological AHF management requires risk stratification in the emergency department and non-invasive ventilation in case of respiratory failure. Vasodilators should be considered as initial therapy in AHF precipitated by hypertension. On the background of recent large randomized clinical trials and international guidelines, this state-of-the-art review describes current pharmacological treatments and potential directions for future research in AHF. | - |
dc.description.sponsorship | B.D. declares no conflict of interest. M.R.C. declares grants for Novartis, Bayer, and V-Wave, and consulting fees for Nuwellis and Boehringer Ingelheim. M.R.C. declares participation of advisory committee and national leader VICTOR HF study. K.S. declares participation of advisory committee and national leader VICTOR HF study, board member of Heart Failure Society of South Africa, and board member of Pan African Society of Cardiology. A.A. declares no conflict of interest. W.M. declares honoraria from Medtronic, Abott, Vifor Pharma, Astra Zeneca, Boehringer Ingelheim, and Pfizer. A.M. declares consulting fees from Novartis, Orion, Roche, Servier, Sanofi, Adrenomed, 4TEEN4, and Philips. All authors declare no funding for this contribution. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Free access | - |
dc.subject.other | Acute heart failure | - |
dc.subject.other | Assessment of congestion | - |
dc.subject.other | Decongestion therapy | - |
dc.subject.other | Non-invasive ventilation | - |
dc.subject.other | Guideline-directed medical therapy | - |
dc.title | Acute heart failure: current pharmacological treatment and perspectives | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4649 | - |
dc.identifier.spage | 4634 | - |
dc.identifier.volume | 44 | - |
local.format.pages | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mebazaa, A (corresponding author), Univ Hosp St Louis Lariboisiere, AP HP, Dept Anesthesia Burn & Crit Care, 2 rue Ambroise Pare, F-75010 Paris, France.; Mebazaa, A (corresponding author), Univ Paris Cite, INSERM, MASCOT, UMR S 942, Paris, France.; Mebazaa, A (corresponding author), Univ Paris Cite, Paris, France.; Mebazaa, A (corresponding author), FHU PROMICE, Paris, France. | - |
dc.description.notes | alexandre.mebazaa@aphp.fr | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/eurheartj/ehad617 | - |
dc.identifier.isi | 001085712200001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Deniau, Benjamin; Mebazaa, Alexandre] Univ Hosp St Louis Lariboisiere, AP HP, Dept Anesthesia Burn & Crit Care, 2 rue Ambroise Pare, F-75010 Paris, France. | - |
local.description.affiliation | [Deniau, Benjamin; Asakage, Ayu; Mebazaa, Alexandre] Univ Paris Cite, INSERM, MASCOT, UMR S 942, Paris, France. | - |
local.description.affiliation | [Deniau, Benjamin; Mebazaa, Alexandre] Univ Paris Cite, Paris, France. | - |
local.description.affiliation | [Deniau, Benjamin; Mebazaa, Alexandre] FHU PROMICE, Paris, France. | - |
local.description.affiliation | [Costanzo, Maria Rosa] Midwest Cardiovasc Inst, Naperville, IL USA. | - |
local.description.affiliation | [Sliwa, Karen] Univ Cape Town, Groote Schuur Hosp, Cape Heart Inst, Fac Hlth Sci,Dept Cardiol & Med, Cape Town, South Africa. | - |
local.description.affiliation | [Mullens, Wilfried] Ziekenhuis Oost Limburg AV, Genk, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried] Hasselt Univ, Hasselt, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Deniau, Benjamin; Costanzo, Maria Rosa; Sliwa, Karen; Asakage, Ayu; MULLENS, Wilfried & Mebazaa, Alexandre (2023) Acute heart failure: current pharmacological treatment and perspectives. In: EUROPEAN HEART JOURNAL, 44, p. 4634–4649. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Deniau, Benjamin | - |
item.contributor | Costanzo, Maria Rosa | - |
item.contributor | Sliwa, Karen | - |
item.contributor | Asakage, Ayu | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Mebazaa, Alexandre | - |
crisitem.journal.issn | 0195-668X | - |
crisitem.journal.eissn | 1522-9645 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Acute heart failure_ current pharmacological treatment and perspectives.pdf | Published version | 1.06 MB | Adobe PDF | View/Open |
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