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http://hdl.handle.net/1942/41814
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DC Field | Value | Language |
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dc.contributor.author | BENTO FONSECA E SILVA, Ana Inês | - |
dc.contributor.author | SLEURS, Hanne | - |
dc.contributor.author | DOCKX, Yinthe | - |
dc.contributor.author | RASKING, Leen | - |
dc.contributor.author | WANG, Congrong | - |
dc.contributor.author | PLUSQUIN, Michelle | - |
dc.contributor.author | BIJNENS, Esmee | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2023-11-16T08:32:28Z | - |
dc.date.available | 2023-11-16T08:32:28Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-11-16T08:22:23Z | - |
dc.identifier.citation | TOXICOLOGY LETTERS, 384 , p. S317 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41814 | - |
dc.description.abstract | Previous epidemiological studies have suggested that air pollution exposure has an adverse effect on bone health in older individuals. However , no studies on early life exposure to air pollution and childhood bone mineral density have been reported. Therefore, this study aims to investigate whether long-term exposure to air pollution is associated with a change in bone mineral density in young children. Within the ongoing prospective birth cohort ENVIRONAGE (Envi-ronmental Influence on Ageing in Early Life), a total of 478 children aged 4-6 were followed-up. Radial bone mineral density (m/s) was assessed using a quantitative ultrasound method. The residential air pollution exposure (μg/m 3) one year before the follow-up was estimated using a high-resolution spatial-temporal interpolation method. Multiple linear regression models were used after adjusting for relevant covariates and potential confounders. Radial bone mineral density was on average (SD) 3680.84 (112.39) m/s. An interquartile (IQR) increment in long-term exposure to PM 2.5 (2.54 μg/m 3) and PM 10 (3.65 μg/m 3) was associated with a decrease of 24.81 m/s (95% CI:-42.55% to-7.07%, p=0.006) and 26.24 m/s (95% CI:-41.95% to 10.54%, p=0.001) in bone mineral density, respectively. On the other hand, no significant associations were observed for long-term exposure to nitrogen dioxide and black carbon. These findings provide evidence that long-term exposure to particulate matter has a relevant effect on childhood bone mineral density. Moreover, this study reinforces the need for increased public health policies and awareness campaigns on air quality improvement with long-term implications on bone health. | - |
dc.description.sponsorship | Flemish Scientific Fund [G073315N/G048420N/G026222P]; European Union | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Air pollution exposure and bone mineral density in young children: results from the ENVIRONAGE birth cohort | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.conferencedate | SEP 10-13, 2023 | - |
local.bibliographicCitation.conferencename | 57th Congress of the European-Societies-of-Toxicology (EUROTOX) | - |
local.bibliographicCitation.conferenceplace | Ljubljana, SLOVENIA | - |
dc.identifier.spage | S317 | - |
dc.identifier.volume | 384 | - |
local.format.pages | 1 | - |
local.bibliographicCitation.jcat | M | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.identifier.isi | 001065901700743 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Silva, A. I.; Sleurs, H.; Rasking, L.; Wang, C.; Plusquin, M.; Bijnens, E. M.; Nawrot, T. S.] Univ Hasselt, Ctr Environm Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Dockx, Y.] Sciensano, Dept Epidemiol & Publ Hlth, Brussels, Belgium. | - |
local.description.affiliation | [Bijnens, E. M.] Open Univ, Dept Environm Sci, Fac Sci, Heerlen, Netherlands. | - |
local.description.affiliation | [Nawrot, T. S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | BENTO FONSECA E SILVA, Ana Inês; SLEURS, Hanne; DOCKX, Yinthe; RASKING, Leen; WANG, Congrong; PLUSQUIN, Michelle; BIJNENS, Esmee & NAWROT, Tim (2023) Air pollution exposure and bone mineral density in young children: results from the ENVIRONAGE birth cohort. In: TOXICOLOGY LETTERS, 384 , p. S317. | - |
item.fulltext | With Fulltext | - |
item.contributor | BENTO FONSECA E SILVA, Ana Inês | - |
item.contributor | SLEURS, Hanne | - |
item.contributor | DOCKX, Yinthe | - |
item.contributor | RASKING, Leen | - |
item.contributor | WANG, Congrong | - |
item.contributor | PLUSQUIN, Michelle | - |
item.contributor | BIJNENS, Esmee | - |
item.contributor | NAWROT, Tim | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0378-4274 | - |
crisitem.journal.eissn | 1879-3169 | - |
Appears in Collections: | Research publications |
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LP-42_ Air pollution exposure and bone mineral density in young children_ results from the ENVIRONAGE birth cohort.pdf Restricted Access | Published version | 185.46 kB | Adobe PDF | View/Open Request a copy |
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