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Title: | Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging | Authors: | Whittier, Danielle E. Bevers, Melissa S. A. M. GEUSENS, Piet VAN DEN BERGH, Joop Gabel, Leigh |
Issue Date: | 2023 | Publisher: | SPRINGER | Source: | Current Osteoporosis Reports, | Status: | Early view | Abstract: | Purpose of ReviewSummarize the recent literature that investigates how advanced medical imaging has contributed to our understanding of skeletal phenotypes and fracture risk across the lifespan.Recent FindingsCharacterization of bone phenotypes on the macro-scale using advanced imaging has shown that while wide bones are generally stronger than narrow bones, they may be more susceptible to age-related declines in bone strength. On the micro-scale, HR-pQCT has been used to identify bone microarchitecture phenotypes that improve stratification of fracture risk based on phenotype-specific risk factors. Adolescence is a key phase for bone development, with distinct sex-specific growth patterns and significant within-sex bone property variability. However, longitudinal studies are needed to evaluate how early skeletal growth impacts adult bone phenotypes and fracture risk. Metabolic and rare bone diseases amplify fracture risk, but the interplay between bone phenotypes and disease remains unclear. Although bone phenotyping is a promising approach to improve fracture risk assessment, the clinical availability of advanced imaging is still limited. Consequently, alternative strategies for assessing and managing fracture risk include vertebral fracture assessment from clinically available medical imaging modalities/techniques or from fracture risk assessment tools based on clinical risk factors.SummaryBone fragility is not solely determined by its density but by a combination of bone geometry, distribution of bone mass, microarchitecture, and the intrinsic material properties of bone tissue. As such, different individuals can exhibit distinct bone phenotypes, which may predispose them to be more vulnerable or resilient to certain perturbations that influence bone strength. | Notes: | Whittier, DE (corresponding author), Univ Calgary, McCaig Inst Bone & Joint Hlth, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada.; Whittier, DE (corresponding author), Univ Calgary, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada.; Whittier, DE (corresponding author), Univ Calgary, Dept Cell Biol & Anat, Calgary, AB, Canada. danielle.whittier@ucalgary.ca |
Keywords: | Bone phenotype;Medical imaging;Fracture risk;Osteoporosis;Bone mineral density;Bone microarchitecture | Document URI: | http://hdl.handle.net/1942/41850 | ISSN: | 1544-1873 | e-ISSN: | 1544-2241 | DOI: | 10.1007/s11914-023-00830-6 | ISI #: | 001091285600001 | Rights: | The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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s11914-023-00830-6.pdf | Early view | 1.62 MB | Adobe PDF | View/Open |
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