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http://hdl.handle.net/1942/41862| Title: | Pyridoxamine Limits Mitochondria-Dependent Ferroptosis in a Rat Model of Doxorubicin-Induced Cardiotoxicity | Authors: | HAESEN, Sibren VERGHOTE, Eline Delaet, Anouk WOLFS, Esther DELUYKER, Dorien BITO, Virginie |
Issue Date: | 2023 | Publisher: | Lippincott Williams & Wilkins | Source: | CIRCULATION, 148 (Suppl_1) , p. A15199 -A15199 | Abstract: | 15199: Pyridoxamine Limits Mitochondria-Dependent Ferroptosis in a Rat Model of Doxorubicin-Induced Cardiotoxic… https://www.ahajournals.org/doi/abs/ Abstract Background: The use of doxorubicin (DOX) chemotherapy is limited by cardiotoxicity characterized by mitochondrial iron accumulation and ferroptosis, both interesting targets for cardioprotection. We found that pyridoxamine (PM) protects against DOX cardiotoxicity in rats. In this study, we hypothesized that PM is cardioprotective by restoring iron regulation and limiting mitochondria-dependent ferroptosis. | Document URI: | http://hdl.handle.net/1942/41862 | Link to publication/dataset: | https://www.ahajournals.org/doi/abs/10.1161/circ.148.suppl_1.15199 | ISSN: | 0009-7322 | e-ISSN: | 1524-4539 | DOI: | 10.1161/circ.148.suppl_1.15199 | Category: | M | Type: | Journal Contribution |
| Appears in Collections: | Research publications |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Abstract 15199_ Pyridoxamine Limits Mitochondria-Dependent Ferroptosis in a Rat Model of Doxorubicin-Induced Cardiotoxicity _ Circulation.pdf | Published version | 528.21 kB | Adobe PDF | View/Open |
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