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http://hdl.handle.net/1942/41863
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DC Field | Value | Language |
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dc.contributor.author | Blokland, Arjan | - |
dc.contributor.author | Jackson, Meyra | - |
dc.contributor.author | PUUSTINEN, Kia | - |
dc.contributor.author | Soeterboek, Jens | - |
dc.contributor.author | Heckman, Pim | - |
dc.date.accessioned | 2023-11-21T11:46:40Z | - |
dc.date.available | 2023-11-21T11:46:40Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2023-11-17T15:12:15Z | - |
dc.identifier.citation | NEUROSCIENCE LETTERS, 818 (Art N°137535) | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41863 | - |
dc.description.abstract | Pattern separation allows us to form discrete representations of information in memory. Pattern separation can be measured in several domains including spatial and object-based discrimination. The brain area largely involved in this process is the dentate gyrus of the hippocampus, which has been shown to be particularly sensitive to the effects of sleep loss. However, methodology in rodent and human studies varies greatly making translational conclusions difficult. Therefore, the aim of the current study was to measure the effects of sleep deprivation on human hippocampal function, using well-validated spatial and object-based pattern separation tests. The effects of acute sleep loss were examined, as this method is frequently used in rodent research but not human studies. Results show that sleep loss impaired performance on the object-based version of the test, but not spatial pattern separation. The findings support the notion that these discrimination projections represent separate but complimentary hippocampal processes, and further elucidates how they may be discretely affected by acute sleep loss. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.rights | 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/bync/4.0/). | - |
dc.subject.other | Hippocampus | - |
dc.subject.other | Sleep deprivation | - |
dc.subject.other | Mnemonic discrimination | - |
dc.subject.other | Perirhinal cortex | - |
dc.subject.other | Parahippocampal cortex | - |
dc.title | Acute sleep loss impairs object but not spatial pattern separation in humans | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 818 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Heckman, PRA (corresponding author), Maastricht Univ, Fac Psychol & Neurosci FPN, Dept Neuropsychol & Psychopharmacol, Univ Singel 40, NL-6229 ER Maastricht, Netherlands. | - |
dc.description.notes | p.heckman@maastrichtuniversity.nl | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 137535 | - |
dc.identifier.doi | 10.1016/j.neulet.2023.137535 | - |
dc.identifier.isi | 001111342300001 | - |
dc.identifier.eissn | 1872-7972 | - |
local.provider.type | - | |
local.description.affiliation | [Blokland, Arjan; Jackson, Meyra; Puustinen, Kia; Soeterboek, Jens; Heckman, Pim R. A.] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands. | - |
local.description.affiliation | [Puustinen, Kia] Hasselt Univ, REVAL Rehabil Res Ctr, Hasselt, Belgium. | - |
local.description.affiliation | [Puustinen, Kia] Katholieke Univ Leuven, Dept Movement Sci, Leuven, Belgium. | - |
local.description.affiliation | [Soeterboek, Jens] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNs, Alzheimer Ctr Limburg, Fac Hlth Med & Life Sci,Dept Psychiat & Neuropsych, Maastricht, Netherlands. | - |
local.description.affiliation | [Heckman, Pim R. A.] Maastricht Univ, Fac Psychol & Neurosci FPN, Dept Neuropsychol & Psychopharmacol, Univ Singel 40, NL-6229 ER Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Blokland, Arjan; Jackson, Meyra; PUUSTINEN, Kia; Soeterboek, Jens & Heckman, Pim (2024) Acute sleep loss impairs object but not spatial pattern separation in humans. In: NEUROSCIENCE LETTERS, 818 (Art N°137535). | - |
item.fulltext | With Fulltext | - |
item.contributor | Blokland, Arjan | - |
item.contributor | Jackson, Meyra | - |
item.contributor | PUUSTINEN, Kia | - |
item.contributor | Soeterboek, Jens | - |
item.contributor | Heckman, Pim | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0304-3940 | - |
crisitem.journal.eissn | 1872-7972 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Blokland (2024) Acute sleep loss impairs object pattern separation.pdf | Published version | 513.41 kB | Adobe PDF | View/Open |
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