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Title: | Incidence, risk assessment and prevention of sudden cardiac death in cardiomyopathies | Authors: | Polovina, Marija Tschoepe, Carsten Rosano, Giuseppe Metra, Marco Crea, Filippo MULLENS, Wilfried Bauersachs, Johann Sliwa, Karen de Boer, Rudolf A. Farmakis, Dimitrios Thum, Thomas Corrado, Domenico Bayes-Genis, Antoni Bozkurt, Biykem Filippatos, Gerasimos Keren, Andre Skouri, Hadi Moura, Brenda Volterrani, Maurizio Abdelhamid, Magdy Asanin, Milika Krljanac, Gordana Tomic, Milenko Savarese, Gianluigi Adamo, Marianna Lopatin, Yuri Chioncel, Ovidiu Coats, Andrew J. S. Seferovic, Petar M. |
Issue Date: | 2023 | Publisher: | WILEY | Source: | EUROPEAN JOURNAL OF HEART FAILURE, | Status: | Early view | Abstract: | Cardiomyopathies are a significant contributor to cardiovascular morbidity and mortality, mainly due to the development of heart failure and increased risk of sudden cardiac death (SCD). Despite improvement in survival with contemporary treatment, SCD remains an important cause of mortality in cardiomyopathies. It occurs at a rate ranging between 0.15% and 0.7% per year (depending on the cardiomyopathy), which significantly surpasses SCD incidence in the age- and sex-matched general population. The risk of SCD is affected by multiple factors including the aetiology, genetic basis, age, sex, physical exertion, the extent of myocardial disease severity, conduction system abnormalities, and electrical instability, as measured by various metrics. Over the past decades, the knowledge on the mechanisms and risk factors for SCD has substantially improved, allowing for a better-informed risk stratification. However, unresolved issues still challenge the guidance of SCD prevention in patients with cardiomyopathies. In this review, we aim to provide an in-depth discussion of the contemporary concepts pertinent to understanding the burden, risk assessment and prevention of SCD in cardiomyopathies (dilated, non-dilated left ventricular, hypertrophic, arrhythmogenic right ventricular, and restrictive). The review first focuses on SCD incidence in cardiomyopathies and then summarizes established and emerging risk factors for life-threatening arrhythmias/SCD. Finally, it discusses validated approaches to the risk assessment and evidence-based measures for SCD prevention in cardiomyopathies, pointing to the gaps in evidence and areas of uncertainties that merit future clarification. [GRAPHICS] . | Notes: | Seferovic, PM (corresponding author), Univ Belgrade, Fac Med, 8 Dr Subot, Belgrade 11000, Serbia.; Seferovic, PM (corresponding author), Serbian Acad Arts & Sci, 35 Knez Mihailova, Belgrade 11000, Serbia. seferovic.petar@gmail.com |
Keywords: | Dilated cardiomyopathy;Non-dilated left ventricular cardiomyopathy;Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Restrictive cardiomyopathy Sudden cardiac death Arrhythmia Incidence Risk stratification Primary prevention | Document URI: | http://hdl.handle.net/1942/41898 | ISSN: | 1388-9842 | e-ISSN: | 1879-0844 | DOI: | 10.1002/ejhf.3076 | ISI #: | 001104517500001 | Rights: | 2023 European Society of Cardiology | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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