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Title: | Blood pressure and renal function responses in workers exposed to lead for up to six years | Authors: | Yu, Yu-Ling AN, Dewei Yang, Wen-Yi Verhamme, Peter Allegaert, Karel Staessen, Jan A. NAWROT, Tim |
Issue Date: | 2023 | Publisher: | WILEY | Source: | JOURNAL OF CLINICAL HYPERTENSION, | Status: | Early view | Abstract: | The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure (BP) and renal function (RF) responses for up to 6 years in the workers without previous occupational lead exposure. BP was the average of five consecutive readings and the estimated glomerular filtration rate was derived from serum creatinine (eGFRcrt) and cystatin C (eGFRcys). Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 mu g/dL). The statistical methods included multivariable-adjusted mixed models and interval-censored Cox regression analysis. The 234 workers analyzed were on average 28.5 years old and included 91.9% men. The baseline BL concentration was 4.35 mu g/dL and increased 3.17-fold over follow-up (median: 2.03 years; range: 0.92-6.45 years). The changes in BP and RF were not significantly correlated with the follow-up-to-baseline BL ratio (p >= .51 and p >= .18, respectively). The fully-adjusted changes in systolic/diastolic BP associated with a doubling of BL were -0.25/-0.12 mm Hg (CI: -0.94 to 0.44/-0.66 to 0.42 mm Hg). Accordingly, the incidence of stage-1 or -2 hypertension was not associated with the BL change (p >= .063). Similarly, the changes in eGFRcrt and eGFRcys associated with a 3-fold BL increment were not significant, amounting to -0.70 mL/min/1.73 m2 (CI: -1.70 to 0.30 mL/min/1.73 m2) and -1.06 mL/min/1.73 m2 (-2.16 to 0.03 mL/min/1.73 m2). In conclusion, the BP and RF responses to an over 3-fold BL increment were small and not significant confirming the safety of modern lead-handing facilities operating under current safety rules. | Notes: | Staessen, JA (corresponding author), Nonprofit Res Assoc Alliance Promot Prevent Med, Leopoldstr 59, BE-2800 Mechelen, Belgium. jan.staessen@appremed.org |
Keywords: | blood pressure;hypertension;lead;occupational exposure;renal function | Document URI: | http://hdl.handle.net/1942/41899 | ISSN: | 1524-6175 | e-ISSN: | 1751-7176 | DOI: | 10.1111/jch.14748 | ISI #: | 001096745800001 | Rights: | 2023 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Blood pressure and renal function responses in workers exposed to lead for up to six years.pdf | Early view | 1.47 MB | Adobe PDF | View/Open |
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