Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/41921
Title: | Fresh perspectives on how to build, maintain and repair the ENS | Authors: | BOESMANS, Werend | Issue Date: | 2023 | Publisher: | NATURE PORTFOLIO | Source: | Nature Reviews Gastroenterology & Hepatology, | Status: | Early view | Abstract: | Enteric nervous system function is essential for survival. Studies published in 2023 have provided important novel insights into the mechanisms that regulate its development and maintenance, and demonstrate how it can be restored when these mechanisms fail. Enteric neuron differentiation trajectories branch off a fundamental gliogenic axis and mature enteric glia preserve the neurogenic properties of early enteric nervous system (ENS) progenitors5.Muscularis macrophages associated with the myenteric plexus transition from an active phagocytic profile during early postnatal stages to an ENS-protective phenotype in the adult gut8.Vagal and sacral neural crest precursors derived from human pluripotent stem cells generate distinct enteric neuron subtypes, exhibit different migratory behaviours and, when combined, can rescue a severe mouse model of Hirschsprung disease9. | Notes: | Boesmans, W (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Diepenbeek, Belgium.; Boesmans, W (corresponding author), Maastricht Univ, Med Ctr, GROW Sch Oncol & Reprod, Dept Pathol, Maastricht, Netherlands. werend.boesmans@uhasselt.be |
Document URI: | http://hdl.handle.net/1942/41921 | ISSN: | 1759-5045 | e-ISSN: | 1759-5053 | DOI: | 10.1038/s41575-023-00870-4 | ISI #: | 001104215500001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s41575-023-00870-4.pdf Restricted Access | Early view | 2.23 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.