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http://hdl.handle.net/1942/41944
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DC Field | Value | Language |
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dc.contributor.author | HOEDEMAKERS, Sarah | - |
dc.contributor.author | VERWERFT, Jan | - |
dc.contributor.author | Reddy, Yogesh N., V | - |
dc.contributor.author | Delvaux, Robin | - |
dc.contributor.author | Stroobants , Sarah | - |
dc.contributor.author | Jogani, Siddharth | - |
dc.contributor.author | CLAESSEN, Guido | - |
dc.contributor.author | Droogmans, Steven | - |
dc.contributor.author | Cosyns, Bernard | - |
dc.contributor.author | Borlaug, Barry A. | - |
dc.contributor.author | HERBOTS, Lieven | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.date.accessioned | 2023-12-15T12:45:07Z | - |
dc.date.available | 2023-12-15T12:45:07Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-12-15T12:36:09Z | - |
dc.identifier.citation | European Heart Journal-Cardiovascular Imaging, 25 (3), p. 302–312 | - |
dc.identifier.issn | 2047-2404 | - |
dc.identifier.uri | http://hdl.handle.net/1942/41944 | - |
dc.description.abstract | Aims To study the impact of heart failure with preserved ejection fraction (HFpEF) vs. aortic stenosis (AS) lesion severity on left ventricular (LV) hypertrophy, diastolic dysfunction, left atrial (LA) dysfunction, haemodynamics, and exercise capacity. Patients (n = 206) with at least moderate AS (aortic valve area <= 0.85 cm/m(2)) and discordant symptoms underwent cardiopulmonary exercise testing with simultaneous echocardiography. The population was stratified according to the probability of underlying HFpEF by the heavy, hypertension, atrial fibrillation, pulmonary hypertension, elder, filling pressure (H2FPEF) score [0-5 (AS/HFpEF-) vs. 6-9 points (AS/HFpEF+)] and AS severity (Moderate vs. Severe). Mean age was 73 +/- 10 years with 40% women. Twenty-eight patients had Severe AS/HFpEF+ (14%), 111 Severe AS/HFpEF- (54%), 13 Moderate AS/HFpEF+ (6%), and 54 Moderate AS/HFpEF- (26%). AS/HFpEF+ vs. AS/HFpEF- patients, irrespective of AS severity, had a lower LV global longitudinal strain, impaired diastolic function, reduced LV compliance, and more pronounced LA dysfunction. The pulmonary arterial pressure-cardiac output slope was significantly higher in AS/HFpEF+ vs. AS/HFpEF- (5.4 +/- 3.1 vs. 3.9 +/- 2.2 mmHg/L/min, respectively; P = 0.003), mainly driven by impaired cardiac output and chronotropic reserve, with signs of right ventricular pulmonary arterial uncoupling. AS/HFpEF+ vs. AS/HFpEF- was associated with a lower peak aerobic capacity (11.5 +/- 3.7 vs. 15.9 +/- 5.9 mL/min/kg, respectively; P < 0.0001) but did not differ between Moderate and Severe AS (14.7 +/- 5.5 vs. 15.2 +/- 5.9 mL/min/kg, respectively; P = 0.6).<br />Conclusion A high H2FPEF score is associated with a reduced exercise capacity and adverse haemodynamics in patients with moderate to severe AS. Both exercise performance and haemodynamics correspond better with intrinsic cardiac dysfunction than AS severity | - |
dc.description.sponsorship | We would like to express our gratitude to four medical students of Hasselt University who contributed to this research work during the summer period of 2021: Febe Joosten, Wietske Vranken, Britt van Gessel, and Jonas Steegmans. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Open access | - |
dc.subject.other | aortic valve stenosis | - |
dc.subject.other | diastolic heart failure | - |
dc.subject.other | exercise test | - |
dc.subject.other | heart atria | - |
dc.subject.other | haemodynamics | - |
dc.title | Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse haemodynamics | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 312 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 302 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Verbrugge, FH (corresponding author), Univ Hosp Brussels, Ctr Cardiovasc Dis, Laarbeeklaan 101, B-1090 Jette, Belgium.; Verbrugge, FH (corresponding author), Mayo Clin, Dept Cardiovasc Med, 1216 2nd St SW, Rochester, MN 55902 USA.; Verbrugge, FH (corresponding author), Vrije Univ Brussel VUB, Fac Med & Pharm, Laarbeeklaan 103, B-1090 Jette, Belgium. | - |
dc.description.notes | frederik.verbrugge@uzbrussel.be | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/ehjci/jead276 | - |
dc.identifier.pmid | 37875135 | - |
dc.identifier.isi | 001102376500001 | - |
dc.contributor.orcid | Verwerft, Jan/0000-0003-2697-0825; Verbrugge, | - |
dc.contributor.orcid | Frederik/0000-0003-0599-9290; Cosyns, Bernard/0000-0001-9419-8019 | - |
dc.identifier.eissn | 2047-2412 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Hoedemakers, Sarah; Verwerft, Jan; Stroobants, Sarah; Jogani, Siddharth; Claessen, Guido; Herbots, Lieven] Jessa Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Hoedemakers, Sarah; Verwerft, Jan; Delvaux, Robin; Herbots, Lieven] UHasselt Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, LCRC, Diepenbeek, Belgium. | - |
local.description.affiliation | [Hoedemakers, Sarah; Droogmans, Steven; Cosyns, Bernard; Verbrugge, Frederik H.] Univ Hosp Brussels, Ctr Cardiovasc Dis, Laarbeeklaan 101, B-1090 Jette, Belgium. | - |
local.description.affiliation | [Reddy, Yogesh N., V; Borlaug, Barry A.; Verbrugge, Frederik H.] Mayo Clin, Dept Cardiovasc Med, 1216 2nd St SW, Rochester, MN 55902 USA. | - |
local.description.affiliation | [Claessen, Guido] Univ Hosp Leuven, Dept Cardiol, Leuven, Belgium. | - |
local.description.affiliation | [Droogmans, Steven; Cosyns, Bernard; Verbrugge, Frederik H.] Vrije Univ Brussel VUB, Fac Med & Pharm, Laarbeeklaan 103, B-1090 Jette, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | HOEDEMAKERS, Sarah; VERWERFT, Jan; Reddy, Yogesh N., V; Delvaux, Robin; Stroobants , Sarah; Jogani, Siddharth; CLAESSEN, Guido; Droogmans, Steven; Cosyns, Bernard; Borlaug, Barry A.; HERBOTS, Lieven & VERBRUGGE, Frederik (2023) Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse haemodynamics. In: European Heart Journal-Cardiovascular Imaging, 25 (3), p. 302–312. | - |
item.contributor | HOEDEMAKERS, Sarah | - |
item.contributor | VERWERFT, Jan | - |
item.contributor | Reddy, Yogesh N., V | - |
item.contributor | Delvaux, Robin | - |
item.contributor | Stroobants , Sarah | - |
item.contributor | Jogani, Siddharth | - |
item.contributor | CLAESSEN, Guido | - |
item.contributor | Droogmans, Steven | - |
item.contributor | Cosyns, Bernard | - |
item.contributor | Borlaug, Barry A. | - |
item.contributor | HERBOTS, Lieven | - |
item.contributor | VERBRUGGE, Frederik | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2047-2404 | - |
crisitem.journal.eissn | 2047-2412 | - |
Appears in Collections: | Research publications |
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Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse haemodynamics.pdf | Published version | 822.73 kB | Adobe PDF | View/Open |
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