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http://hdl.handle.net/1942/42034
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DC Field | Value | Language |
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dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Spirito, Alessandro | - |
dc.contributor.author | Sartori, Samantha | - |
dc.contributor.author | Angiolillo, Dominick J. | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Hernandez, Jose M. de la Torre | - |
dc.contributor.author | Krucoff, Mitchell W. | - |
dc.contributor.author | Bangalore, Sripal | - |
dc.contributor.author | Bhatt, Deepak L. | - |
dc.contributor.author | Campo, Gianluca | - |
dc.contributor.author | Cao, Davide | - |
dc.contributor.author | Chehab, Bassem M. | - |
dc.contributor.author | Choi, James W. | - |
dc.contributor.author | Feng, Yihan | - |
dc.contributor.author | Ge, Junbo | - |
dc.contributor.author | Hermiller, James | - |
dc.contributor.author | Kunadian, Vijay | - |
dc.contributor.author | Lupo, Sydney | - |
dc.contributor.author | Makkar, Raj R. | - |
dc.contributor.author | Maksoud, Aziz | - |
dc.contributor.author | Neumann, Franz-Josef | - |
dc.contributor.author | Picon, Hector | - |
dc.contributor.author | Saito, Shigeru | - |
dc.contributor.author | Sardella, Gennaro | - |
dc.contributor.author | Thiele, Holger | - |
dc.contributor.author | Toelg, Ralph | - |
dc.contributor.author | Varenne, Olivier | - |
dc.contributor.author | Vogel, Birgit | - |
dc.contributor.author | Zhou, Yujie | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Mehran, Roxana | - |
dc.date.accessioned | 2024-01-05T07:30:48Z | - |
dc.date.available | 2024-01-05T07:30:48Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-01-04T15:02:30Z | - |
dc.identifier.citation | JACC-Cardiovascular Interventions, 16 (20) , p. 2498 -2510 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42034 | - |
dc.description.abstract | BACKGROUND The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients on long-term oral anticoagulation (OAC) therapy is still uncertain. OBJECTIVES The aim of this analysis was to assess the effects of 1-vs 3-month DAPT in patients with and those without concomitant OAC included in the XIENCE Short DAPT program. METHODS The XIENCE Short DAPT program enrolled patients with high bleeding risk who underwent successful PCI with a cobalt-chromium everolimus-eluting stent. DAPT was discontinued at 1 or 3 months in patients free from ischemic events and adherent to treatment. The effect of 1-vs 3-month DAPT was compared in patients with and those without OAC using propensity score stratification. The primary endpoint was all-cause death or any myocardial infarction (MI). The key secondary endpoint was Bleeding Academic Research Consortium (BARC) types 2 to 5 bleeding. Outcomes were assessed from 1 to 12 months after index PCI. RESULTS Among 3,364 event-free patients, 1,462 (43%) were on OAC. Among OAC patients, the risk for death or MI was similar between 1-and 3-month DAPT (7.4% vs 8.8%; adjusted HR: 0.74; 95% CI: 0.49-1.11; P = 0.139), whereas BARC types 2 to 5 bleeding was lower with 1-month DAPT (adjusted HR: 0.71; 95% CI: 0.51-0.99; P = 0.046). These effects were consistent in patients with and those without OAC (P for interaction = NS). CONCLUSIONS Between 1 and 12 months after PCI, 1-month compared with 3-month DAPT was associated with similar rates of all-cause death or MI and a reduced rate of BARC types 2 to 5 bleeding, irrespective of OAC treatment. (J Am Coll Cardiol Intv 2023;16:2498-2510) (c) 2023 by the American College of Cardiology Foundation. | - |
dc.description.sponsorship | Abbott | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject.other | KEY WORDS dual antiplatelet therapy | - |
dc.subject.other | everolimus-eluting stent(s) | - |
dc.subject.other | high bleeding risk | - |
dc.subject.other | oral anticoagulant therapy | - |
dc.subject.other | percutaneous coronary intervention | - |
dc.title | 1-or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2510 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 2498 | - |
dc.identifier.volume | 16 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mehran, R (corresponding author), Icahn Sch Med Mt Sinai, 1 Gustave L Levy Pl,Box 1030, New York, NY 10029 USA. | - |
dc.description.notes | roxana.mehran@mountsinai.org | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jcin.2023.08.014 | - |
dc.identifier.pmid | 37804290 | - |
dc.identifier.isi | 001116471300001 | - |
dc.contributor.orcid | Bhatt, Deepak L/0000-0002-1278-6245; Spirito, | - |
dc.contributor.orcid | Alessandro/0000-0002-7473-6577; Sartori, Samantha/0000-0003-0618-9409 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Valgimigli, Marco] Ente Osped Cantonale, Cardioctr, Ticino Inst, Lugano, Switzerland. | - |
local.description.affiliation | [Valgimigli, Marco] Bern Univ Hosp, Bern, Switzerland. | - |
local.description.affiliation | [Spirito, Alessandro; Sartori, Samantha; Cao, Davide; Lupo, Sydney; Vogel, Birgit; Mehran, Roxana] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA. | - |
local.description.affiliation | [Angiolillo, Dominick J.] Univ Florida, Coll Med, Div Cardiol, Jacksonville, FL USA. | - |
local.description.affiliation | [Vranckx, Pascal] Jessa Ziekenhuis, Dept Cardiol & Crit Care Med, Hasselt, Belgium. | - |
local.description.affiliation | [Vranckx, Pascal] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Hernandez, Jose M. de la Torre] Hosp Univ Marques de Valdecilla, IDIVAL, Santander, Spain. | - |
local.description.affiliation | [Krucoff, Mitchell W.] Duke Univ, Med Ctr, Div Cardiol, Durham, NC USA. | - |
local.description.affiliation | [Krucoff, Mitchell W.] Duke Clin Res Inst, Durham, NC USA. | - |
local.description.affiliation | [Bangalore, Sripal] NYU, Grossman Sch Med, New York, NY USA. | - |
local.description.affiliation | [Bhatt, Deepak L.] Mt Sinai Hlth Syst, Icahn Sch Med, Mt Sinai Heart, New York, NY USA. | - |
local.description.affiliation | [Campo, Gianluca] Univ Ferrara, Malattie Apparat Cardiovasc, Ferrara, Italy. | - |
local.description.affiliation | [Cao, Davide] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, Italy. | - |
local.description.affiliation | [Chehab, Bassem M.] Ascens Via Christi Hosp, Cardiovasc Res Inst Kansas, Wichita, KS USA. | - |
local.description.affiliation | [Choi, James W.] Presbyterian Med Ctr, Dallas, TX USA. | - |
local.description.affiliation | [Ge, Junbo] Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China. | - |
local.description.affiliation | [Hermiller, James] Ascension St Vincent Heart Ctr, Ascens St, Carmel, IN USA. | - |
local.description.affiliation | [Kunadian, Vijay] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, England. | - |
local.description.affiliation | [Kunadian, Vijay] Freeman Rd Hosp, Newcastle Upon Tyne Hosp NHS Fdn Trust, Cardiothorac Ctr, Newcastle Upon Tyne, England. | - |
local.description.affiliation | [Makkar, Raj R.] Cedars Sinai Med Ctr, Los Angeles, CA USA. | - |
local.description.affiliation | [Maksoud, Aziz] Kansas Heart Hosp, Wichita, KS USA. | - |
local.description.affiliation | [Maksoud, Aziz] Univ Kansas, Sch Med, Wichita, KS USA. | - |
local.description.affiliation | [Neumann, Franz-Josef] Univ Freiburg, Univ Heart Ctr Freiburg Bad Krozingen Med Ctr, Dept Cardiol & Angiol, Freiburg, Germany. | - |
local.description.affiliation | [Picon, Hector] Redmond Reg Med Ctr, Rome, GA USA. | - |
local.description.affiliation | [Saito, Shigeru] Shonan Kamakura Gen Hosp, Kamakura, Japan. | - |
local.description.affiliation | [Sardella, Gennaro] Policlin Umberto I Roma, Rome, Italy. | - |
local.description.affiliation | [Thiele, Holger] Univ Leipzig, Ctr Leipzig, Leipzig, Germany. | - |
local.description.affiliation | [Thiele, Holger] Leipzig Heart Inst, Leipzig, Germany. | - |
local.description.affiliation | [Thiele, Holger] Hosp Cochin, Paris, France. | - |
local.description.affiliation | [Toelg, Ralph] Herzzentrum, Segeberger Kliniken, Bad Segeberg, Germany. | - |
local.description.affiliation | [Varenne, Olivier] Ctr Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Varenne, Olivier] Univ Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Zhou, Yujie] Beijing AnZhen Hosp, Beijing, Peoples R China. | - |
local.description.affiliation | [Windecker, Stephan] Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland. | - |
local.description.affiliation | [Mehran, Roxana] Icahn Sch Med Mt Sinai, 1 Gustave L Levy Pl,Box 1030, New York, NY 10029 USA. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Valgimigli, Marco; Spirito, Alessandro; Sartori, Samantha; Angiolillo, Dominick J.; VRANCKX, Pascal; Hernandez, Jose M. de la Torre; Krucoff, Mitchell W.; Bangalore, Sripal; Bhatt, Deepak L.; Campo, Gianluca; Cao, Davide; Chehab, Bassem M.; Choi, James W.; Feng, Yihan; Ge, Junbo; Hermiller, James; Kunadian, Vijay; Lupo, Sydney; Makkar, Raj R.; Maksoud, Aziz; Neumann, Franz-Josef; Picon, Hector; Saito, Shigeru; Sardella, Gennaro; Thiele, Holger; Toelg, Ralph; Varenne, Olivier; Vogel, Birgit; Zhou, Yujie; Windecker, Stephan & Mehran, Roxana (2023) 1-or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI. In: JACC-Cardiovascular Interventions, 16 (20) , p. 2498 -2510. | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Spirito, Alessandro | - |
item.contributor | Sartori, Samantha | - |
item.contributor | Angiolillo, Dominick J. | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Hernandez, Jose M. de la Torre | - |
item.contributor | Krucoff, Mitchell W. | - |
item.contributor | Bangalore, Sripal | - |
item.contributor | Bhatt, Deepak L. | - |
item.contributor | Campo, Gianluca | - |
item.contributor | Cao, Davide | - |
item.contributor | Chehab, Bassem M. | - |
item.contributor | Choi, James W. | - |
item.contributor | Feng, Yihan | - |
item.contributor | Ge, Junbo | - |
item.contributor | Hermiller, James | - |
item.contributor | Kunadian, Vijay | - |
item.contributor | Lupo, Sydney | - |
item.contributor | Makkar, Raj R. | - |
item.contributor | Maksoud, Aziz | - |
item.contributor | Neumann, Franz-Josef | - |
item.contributor | Picon, Hector | - |
item.contributor | Saito, Shigeru | - |
item.contributor | Sardella, Gennaro | - |
item.contributor | Thiele, Holger | - |
item.contributor | Toelg, Ralph | - |
item.contributor | Varenne, Olivier | - |
item.contributor | Vogel, Birgit | - |
item.contributor | Zhou, Yujie | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Mehran, Roxana | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1936-8798 | - |
crisitem.journal.eissn | 1876-7605 | - |
Appears in Collections: | Research publications |
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