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DC Field | Value | Language |
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dc.contributor.author | DHONT, Sebastiaan | - |
dc.contributor.author | STASSEN, Jan | - |
dc.contributor.author | HERBOTS, Lieven | - |
dc.contributor.author | HOEDEMAKERS, Sarah | - |
dc.contributor.author | BEKHUIS, Youri | - |
dc.contributor.author | Jasaityte, Ruta | - |
dc.contributor.author | Stroobants , Sarah | - |
dc.contributor.author | Petit, Thibault | - |
dc.contributor.author | Bakelants, Elise | - |
dc.contributor.author | FALTER, Maarten | - |
dc.contributor.author | MOURA FERREIRA, Sara | - |
dc.contributor.author | CLAESSEN, Guido | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | VANDERVOORT, Pieter | - |
dc.contributor.author | BERTRAND, Philippe | - |
dc.contributor.author | VERWERFT, Jan | - |
dc.date.accessioned | 2024-01-05T10:01:51Z | - |
dc.date.available | 2024-01-05T10:01:51Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-01-05T08:59:12Z | - |
dc.identifier.citation | European Heart Journal-Cardiovascular Imaging, | - |
dc.identifier.uri | http://hdl.handle.net/1942/42040 | - |
dc.description.abstract | Aims Exercise-induced pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure over cardiac output (mPAP/ CO) slope >3 mmHg/L/min, has important diagnostic and prognostic implications. The aim of this study is to investigate the value of the mPAP/CO slope in patients with more than moderate primary mitral regurgitation (MR) with preserved ejection fraction and no or discordant symptoms. Methods and results A total of 128 consecutive patients were evaluated with exercise echocardiography and cardiopulmonary testing. Clinical outcome was defined as the composite of mitral valve intervention, new-onset atrial fibrillation, cardiovascular hospitalization, and all-cause mortality. The mean age was 63 years, 61% were male, and the mean LVEF was 66 +/- 6%. The mPAP/CO slope correlated with peak VO2 (r = -0.52, P < 0.001), while the peak systolic pulmonary artery pressure (sPAP) did not (r = -0.06, P = 0.584). Forty-six per cent (n = 59) had peak exercise sPAP >= 60 mmHg, and 37% (n = 47) had mPAP/CO slope >3 mmHg/L/min. Event-free survival was 55% at 1 year and 46% at 2 years, with reduced survival in patients with mPAP/CO slope >3 mmHg/L/min (hazard ratio, 4.9; 95% confidence interval, 2.9-8.2; P < 0.001). In 53 cases (41%), mPAP/CO slope and peak sPAP were discordant: patients with slope >3 mmHg/L/mmHg and sPAP <60 mmHg (n = 21) had worse outcome vs. peak sPAP >= 60 mmHg and normal slope (n = 32, log-rank P = 0.003). The mPAP/CO slope improved predictive models for outcome, incremental to resting and exercise sPAP, and peak VO2. Conclusion Exercise PH defined by the mPAP/CO slope >3 mmHg/L/min is associated with decreased exercise capacity and a higher risk of adverse events in significant primary MR and no or discordant symptoms. The slope provides a greater prognostic value than single sPAP measures and peak VO2. [GRAPHICS] . | - |
dc.description.sponsorship | S.D. is supported as a predoctoral fundamental research fellow by the Fund for Scientific Research Flanders (FWO 11PGA24N). | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | - |
dc.subject.other | primary mitral regurgitation | - |
dc.subject.other | CPETecho | - |
dc.subject.other | mPAP/CO slope | - |
dc.subject.other | exercise pulmonary hypertension | - |
dc.title | Exercise pulmonary hypertension by the mPAP/CO slope in primary mitral regurgitation | - |
dc.type | Journal Contribution | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bertrand, PB (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Synaps Pk 1, B-3600 Genk, Belgium.; Bertrand, PB (corresponding author), Hasselt Univ, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | philippe.bertrand@zol.be | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1093/ehjci/jead313 | - |
dc.identifier.pmid | 37976175 | - |
dc.identifier.isi | 001119598800001 | - |
dc.contributor.orcid | Verwerft, Jan/0000-0003-2697-0825; Bekhuis, Youri/0000-0003-3903-5051 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Dhont, Sebastiaan; Nijst, Petra; Vandervoort, Pieter M.; Bertrand, Philippe B.] Ziekenhuis Oost Limburg, Dept Cardiol, Synaps Pk 1, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Dhont, Sebastiaan; Herbots, Lieven; Hoedemakers, Sarah; Bekhuis, Youri; Falter, Maarten; Ferreira, Sara Moura; Vandervoort, Pieter M.; Bertrand, Philippe B.; Verwerft, Jan] Hasselt Univ, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Stassen, Jan; Herbots, Lieven; Hoedemakers, Sarah; Bekhuis, Youri; Jasaityte, Ruta; Stroobants, Sarah; Falter, Maarten; Ferreira, Sara Moura; Claessen, Guido; Verwerft, Jan] Jessa Hosp, Dept Cardiol, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Bakelants, Elise] Imeldaziekenhuis, Dept Cardiol, B-2820 Bonheiden, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.accessRights | Embargoed Access | - |
item.embargoEndDate | 2024-05-17 | - |
item.fullcitation | DHONT, Sebastiaan; STASSEN, Jan; HERBOTS, Lieven; HOEDEMAKERS, Sarah; BEKHUIS, Youri; Jasaityte, Ruta; Stroobants , Sarah; Petit, Thibault; Bakelants, Elise; FALTER, Maarten; MOURA FERREIRA, Sara; CLAESSEN, Guido; NIJST, Petra; VANDERVOORT, Pieter; BERTRAND, Philippe & VERWERFT, Jan (2023) Exercise pulmonary hypertension by the mPAP/CO slope in primary mitral regurgitation. In: European Heart Journal-Cardiovascular Imaging,. | - |
item.contributor | DHONT, Sebastiaan | - |
item.contributor | STASSEN, Jan | - |
item.contributor | HERBOTS, Lieven | - |
item.contributor | HOEDEMAKERS, Sarah | - |
item.contributor | BEKHUIS, Youri | - |
item.contributor | Jasaityte, Ruta | - |
item.contributor | Stroobants , Sarah | - |
item.contributor | Petit, Thibault | - |
item.contributor | Bakelants, Elise | - |
item.contributor | FALTER, Maarten | - |
item.contributor | MOURA FERREIRA, Sara | - |
item.contributor | CLAESSEN, Guido | - |
item.contributor | NIJST, Petra | - |
item.contributor | VANDERVOORT, Pieter | - |
item.contributor | BERTRAND, Philippe | - |
item.contributor | VERWERFT, Jan | - |
crisitem.journal.issn | 2047-2404 | - |
crisitem.journal.eissn | 2047-2412 | - |
Appears in Collections: | Research publications |
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