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http://hdl.handle.net/1942/42083
Title: | Generalized Pairwise Comparisons to Assess Treatment Effects: JACC Review Topic of the Week | Authors: | VERBEECK, Johan De Backer, Mickael VERWERFT, Jan Salvaggio, Samuel Valgimigli, Marco VRANCKX, Pascal BUYSE, Marc Brunner, Edgar |
Issue Date: | 2023 | Publisher: | ELSEVIER SCIENCE INC | Source: | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 82 (13) , p. 1360 -1372 | Abstract: | A time-to-first-event composite endpoint analysis has well-known shortcomings in evaluating a treatment effect in cardiovascular clinical trials. It does not fully describe the clinical benefit of therapy because the severity of the events, events repeated over time, and clinically relevant nonsurvival outcomes cannot be considered. The generalized pairwise comparisons (GPC) method adds flexibility in defining the primary endpoint by including any number and type of outcomes that best capture the clinical benefit of a therapy as compared with standard of care. Clinically important outcomes, including bleeding severity, number of interventions, and quality of life, can easily be integrated in a single analysis. The treatment effect in GPC can be expressed by the net treatment benefit, the success odds, or the win ratio. This review provides guidance on the use of GPC and the choice of treatment effect measures for the analysis and reporting of cardiovascular trials. | Notes: | Verbeeck, J (corresponding author), Univ Hasselt, DSI, I BioStat, Agoralaan Gebouw D, B-3590 Hasselt, Belgium. johan.verbeeck@uhasselt.be |
Keywords: | absolute treatment effect;biostatistics;clinical trials;composite endpoints;endpoint determinations;generalized pairwise comparisons;net treatment benefit;randomized controlled trials as topic;relative treatment effect;success odds;survival analysis;win ratio | Document URI: | http://hdl.handle.net/1942/42083 | ISSN: | 0735-1097 | e-ISSN: | 1558-3597 | DOI: | 10.1016/j.jacc.2023.06.047 | ISI #: | 001124754500001 | Rights: | 2023 by the American College of Cardiology Foundation. Published by Elsevier. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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published version.pdf Restricted Access | Published version | 3.17 MB | Adobe PDF | View/Open Request a copy |
auteursversion.pdf | Peer-reviewed author version | 8.17 MB | Adobe PDF | View/Open |
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