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http://hdl.handle.net/1942/42086
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DC Field | Value | Language |
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dc.contributor.author | MISHRA, Shradha | - |
dc.contributor.author | VAN DER STUKKEN, Charlotte | - |
dc.contributor.author | Drury, Stacy | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | MARTENS, Dries | - |
dc.date.accessioned | 2024-01-10T12:40:54Z | - |
dc.date.available | 2024-01-10T12:40:54Z | - |
dc.date.issued | 2024 | - |
dc.date.submitted | 2023-12-22T11:06:19Z | - |
dc.identifier.citation | ENVIRONMENTAL RESEARCH, 244 (Art N° 117990) | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42086 | - |
dc.description.abstract | Background Telomere length (TL) and mitochondrial DNA (mtDNA) are central markers of vital biological mechanisms, including cellular aging. Prenatal air pollution exposure may impact molecular markers of aging leading to adverse health effects. Objective To perform a systematic review on human population-based studies investigating the association between prenatal air pollution exposure and TL or mtDNA content at birth. Methodology Searches were undertaken on PubMed and Web of Science until July 2023. The framework of the review was based on the PRISMA-P guidelines. Results Nineteen studies studied prenatal air pollution and TL or mtDNA content at birth. Studies investigating TL or mtDNA content measured at any other time or did not evaluate prenatal air pollution were excluded. Twelve studies (including 4381 participants with study sample range: 97 to 743 participants) investigated newborn TL and eight studies (including 3081 participants with study sample range: 120 to 743 participants) investigated mtDNA content at birth. Seven studies focused on particulate matter (PM2.5) exposure and newborn TL of which all, except two, showed an inverse association in at least one of the gestational trimesters. Of the eight studies on mtDNA content, four focused on PM2.5 air pollution with two of them reporting an inverse association. For PM2.5 exposure, observations on trimester-specific effects were inconsistent. Current literature showing associations with other prenatal air pollutants (including nitrogen oxides, sulfur dioxide, carbon monoxide and ozone) is inconsistent. Conclusion This review provides initial evidence that prenatal PM2.5 exposure impacts the telomere-mitochondrial axis of aging at birth. The current evidence did not reveal harmonious observations for trimester-specific associations nor showed consistent effects of other air pollutants. Future studies should elucidate the specific contribution of prenatal exposure to pollutants other than PM in relation to TL and mtDNA content at birth, and the potential later life health consequences. | - |
dc.description.sponsorship | This study has received funding from the European Union’s Horizon 2020 research and innovation programme ‘SURREAL’ under grant agreement No 956780. TSN holds funding by Methusalem. SD holds funding by National Institutes of Health (NIH U24AG066528). DSM holds a postdoctoral grant by the Research Foundation-Flanders (FWO12X9623N). | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.rights | 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). | - |
dc.subject.other | Air pollution | - |
dc.subject.other | Mitochondrial DNA | - |
dc.subject.other | Prenatal exposure | - |
dc.subject.other | Telomere length | - |
dc.subject.other | Early life | - |
dc.subject.other | Newborns | - |
dc.title | Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 244 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Martens, DS (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan gebouw,D, BE-3590 Diepenbeek, Belgium. | - |
local.publisher.place | 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 117990 | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 956780 | - |
dc.identifier.doi | 10.1016/j.envres.2023.117990 | - |
dc.identifier.pmid | 38141917 | - |
dc.identifier.isi | 001156466700001 | - |
dc.identifier.eissn | 1096-0953 | - |
local.provider.type | CrossRef | - |
local.provider.type | CrossRef | - |
local.description.affiliation | [Mishra, Shradha; Van Der Stukken, Charlotte; Nawrot, Tim S.; Martens, Dries S.] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Drury, Stacy] Harvard Med Sch, Boston Childrens Hosp, Dept Psychiat & Behav Sci, Boston, MA 02115 USA. | - |
local.description.affiliation | [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Occupat & Environm Med, Leuven, Belgium. | - |
local.description.affiliation | [Martens, Dries S.] Hasselt Univ, Ctr Environm Sci, Agoralaan gebouw,D, BE-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | MISHRA, Shradha; VAN DER STUKKEN, Charlotte; Drury, Stacy; NAWROT, Tim & MARTENS, Dries (2024) Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review. In: ENVIRONMENTAL RESEARCH, 244 (Art N° 117990). | - |
item.accessRights | Open Access | - |
item.contributor | MISHRA, Shradha | - |
item.contributor | VAN DER STUKKEN, Charlotte | - |
item.contributor | Drury, Stacy | - |
item.contributor | NAWROT, Tim | - |
item.contributor | MARTENS, Dries | - |
crisitem.journal.issn | 0013-9351 | - |
crisitem.journal.eissn | 1096-0953 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Prenatal air pollution exposure in relation to the telomere.pdf | Published version | 818.98 kB | Adobe PDF | View/Open |
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