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http://hdl.handle.net/1942/42108
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DC Field | Value | Language |
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dc.contributor.author | Cools, Nathalie | - |
dc.contributor.author | Willekens, Barbara | - |
dc.contributor.author | Presas-Rodriguez, Silvia | - |
dc.contributor.author | Ten Brinke, Anja | - |
dc.contributor.author | Gross, Catharina C. | - |
dc.contributor.author | Mansilla, Maria Jose | - |
dc.contributor.author | Teniente-Sera, Aina | - |
dc.contributor.author | WENS, Inez | - |
dc.contributor.author | Billiet, Thibo | - |
dc.contributor.author | Schulte-Mecklenbeck, Andreas | - |
dc.contributor.author | Derdelinckx, Judith | - |
dc.contributor.author | Di Blasi, Daniela | - |
dc.contributor.author | Cabeza, Virginia Palomares | - |
dc.contributor.author | Ribbens, Annemie | - |
dc.contributor.author | Van Hecke, Wim | - |
dc.contributor.author | Barriocanal, Anna Maria | - |
dc.contributor.author | Quirant-Sanchez, Bibiana | - |
dc.contributor.author | Verheij, Herman | - |
dc.contributor.author | Peelen, Sjaak | - |
dc.contributor.author | Cras, Patrick | - |
dc.contributor.author | Snoeckx, Annemiek | - |
dc.contributor.author | Massuet-Vilamajo, Anna | - |
dc.contributor.author | Reverter, Jorge | - |
dc.contributor.author | Dams, Amber | - |
dc.contributor.author | Nijs, Griet | - |
dc.contributor.author | Sampedro, Cristina Calvino | - |
dc.contributor.author | De Cerio, Ascension Lopez Diaz | - |
dc.contributor.author | Inoges, Susana | - |
dc.contributor.author | Prosper, Felipe | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Wiendl, Heinz | - |
dc.contributor.author | Van Ham, S. Marieke | - |
dc.contributor.author | Berneman, Zwi | - |
dc.contributor.author | Tello, Cristina Ramo | - |
dc.contributor.author | Martinez-Caceres, Eva | - |
dc.date.accessioned | 2024-01-12T12:41:35Z | - |
dc.date.available | 2024-01-12T12:41:35Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2024-01-12T08:31:35Z | - |
dc.identifier.citation | Multiple Sclerosis Journal, 29 , p. 598 -600 | - |
dc.identifier.issn | 1352-4585 | - |
dc.identifier.uri | http://hdl.handle.net/1942/42108 | - |
dc.description.abstract | Results: Mean (standard deviation [SD]) ozanimod exposure among 185 enroled patients was 13.7 (8.6) mos (210.9 person-years [PY] total exposure); 1 patient had completed and 155 (83.8%) were on treatment at data cutoff. Baseline characteristics (N=185) included mean (SD) age 39.5 (10.7) y; 78.4% female; 85.9% White; 10.8% Black; 72.4% DMT naïve; mean 4.1 (5.5) y since MS symptom onset; mean 0.8 (0.8) relapses in prior 12 mos; and median EDSS score 2.0 (range 0㎕4). At baseline, mean (SD) SDMT score was 53.9 (11.4); after 1 y of ozanimod, 55/116 (47.4%) had ⩾4-pt or 10% improvement, 30 (25.9%) remained stable, and 31 (26.7%) had a ⩾4-pt or 10% worsening. Mean (SD) T2 lesion count at baseline (n=184) was 22.4 (16.9); mean (SD) new/enlarging T2 lesion count at 1 y (n=101) was 0.4 (0.8). Also, 91/100 (91.0%) patients with MRI data were GdE lesion-free at 1 y vs 123/185 (66.5%) at baseline. TEAEs occurred in 122 (65.9%) patients (EAIR 161.8/100 PY); TEAEs present in ⩾5% were (%; | - |
dc.description.sponsorship | A FACTT network (Cost Action) [BM1305]; European Union [779316]; | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject.other | ADB: has received speaker bureau | - |
dc.subject.other | advisory board | - |
dc.subject.other | steering com- mittee | - |
dc.subject.other | and/or consulting fees for Alexion | - |
dc.subject.other | Biogen | - |
dc.subject.other | Bristol Myers Squibb | - |
dc.subject.other | EMD Serono | - |
dc.subject.other | Horizon Therapeutics | - |
dc.subject.other | Mallinckrodt | - |
dc.subject.other | Novartis | - |
dc.subject.other | Roche-Genentech | - |
dc.subject.other | Sanofi-Genzyme | - |
dc.subject.other | and TG Therapeutics; clinical trials for Bristol Myers Squibb | - |
dc.subject.other | and TG Therapeutics AZO: speaker bureau | - |
dc.subject.other | advisory boards | - |
dc.subject.other | steering committees | - |
dc.subject.other | and/ or consulting fees for Alexion Pharmaceuticals | - |
dc.subject.other | Banner Life Sciences | - |
dc.subject.other | BD Biosciences | - |
dc.subject.other | Biologix | - |
dc.subject.other | Celgene | - |
dc.subject.other | Genentech | - |
dc.subject.other | GW Pharma | - |
dc.subject.other | Jazz Pharmaceuticals | - |
dc.subject.other | Novartis (local and global) | - |
dc.subject.other | Sandoz Pharmaceuticals | - |
dc.subject.other | Sanofi/Genzyme | - |
dc.subject.other | TG Therapeutics | - |
dc.subject.other | and | - |
dc.title | Safety, feasibility and tolerability of intranodal and intradermal administration of tolerogenic dendritic cell therapy in active multiple sclerosis | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.conferencedate | OCT 11-13, 2023 | - |
local.bibliographicCitation.conferencename | 9th Joint ECTRIMS-ACTRIMS meeting | - |
local.bibliographicCitation.conferenceplace | Milan, ITALY | - |
dc.identifier.epage | 600 | - |
dc.identifier.spage | 598 | - |
dc.identifier.volume | 29 | - |
local.format.pages | 3 | - |
local.bibliographicCitation.jcat | M | - |
local.publisher.place | 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.identifier.isi | 001091311304065 | - |
dc.identifier.eissn | 1477-0970 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Cools, Nathalie; Willekens, Barbara; Dams, Amber; Berneman, Zwi] Univ Antwerp, Lab Expt Hematol, Fac Med & Hlth Sci, Antwerp, Belgium. | - |
local.description.affiliation | [Cools, Nathalie; Nijs, Griet] Univ Antwerp Hosp, Ctr Cell Therapy & Regenerat Med, Edegem, Belgium. | - |
local.description.affiliation | [Willekens, Barbara; Derdelinckx, Judith; Cras, Patrick] Antwerp Univ Hosp, Dept Neurol, Edegem, Belgium. | - |
local.description.affiliation | [Willekens, Barbara] Univ Antwerp, Translat Neurosci Res Grp, Fac Med & Hlth Sci, Antwerp, Belgium. | - |
local.description.affiliation | [Presas-Rodriguez, Silvia; Tello, Cristina Ramo] Hosp Badalona Germans Trias & Pujol, Dept Neurosci, Multiple Sclerosis Unit, Badalona, Spain. | - |
local.description.affiliation | [Presas-Rodriguez, Silvia] Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles, Spain. | - |
local.description.affiliation | [Ten Brinke, Anja; Di Blasi, Daniela; Cabeza, Virginia Palomares; Van Ham, S. Marieke] Sanquin Res, Dept Immunopathol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Ten Brinke, Anja; Van Ham, S. Marieke] Amsterdam UMC, Landsteiner Lab, Amsterdam, Netherlands. | - |
local.description.affiliation | [Gross, Catharina C.; Schulte-Mecklenbeck, Andreas; Wiendl, Heinz] Univ Hosp & Univ Munster, Dept Neurol Inst Translat Neurol, Munster, Germany. | - |
local.description.affiliation | [Mansilla, Maria Jose; Teniente-Sera, Aina; Quirant-Sanchez, Bibiana; Martinez-Caceres, Eva] Hosp Badalona Germans Trias & Pujol, Div Immunol, Badalona, Spain. | - |
local.description.affiliation | [Teniente-Sera, Aina; Martinez-Caceres, Eva] Univ Autonoma Barcelona, Dept Cellular Biol Physiol & Immunol, Bellaterra, Spain. | - |
local.description.affiliation | [Ribbens, Annemie; Van Hecke, Wim] Icometrix NV, Leuven, NV, Belgium. | - |
local.description.affiliation | [Barriocanal, Anna Maria] Germans Trias & Pujol Hlth Sci Res Inst, Clin Res Polyvalent Unit, Badalona, Spain. | - |
local.description.affiliation | [Verheij, Herman; Peelen, Sjaak] Lygature, Utrecht, Netherlands. | - |
local.description.affiliation | [Snoeckx, Annemiek] Antwerp Univ Hosp, Dept Radiol, Edegem, Belgium. | - |
local.description.affiliation | [Massuet-Vilamajo, Anna] Hosp Badalona Germans Trias & Pujol, Dept Radiol, Badalona, Spain. | - |
local.description.affiliation | [Reverter, Jorge] Hosp Badalona Germans Trias & Pujol, Dept Endocrinol, Badalona, Spain. | - |
local.description.affiliation | [Sampedro, Cristina Calvino; De Cerio, Ascension Lopez Diaz; Inoges, Susana; Prosper, Felipe] Clin Univ Navarra, Hematol Cell Therapy Area, Pamplona, Spain. | - |
local.description.affiliation | [Hens, Niel] Univ Antwerp, CHERMID, VAXINFECTIO, Antwerp, Belgium. | - |
local.description.affiliation | [Hens, Niel] Univ Hasselt, Ctr Stat, I Biostat, Hasselt, Belgium. | - |
local.description.affiliation | [Van Ham, S. Marieke] Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands. | - |
local.description.affiliation | [Martinez-Caceres, Eva] Germans Trias & Pujol Res Inst, Badalona, Spain. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Cools, Nathalie; Willekens, Barbara; Presas-Rodriguez, Silvia; Ten Brinke, Anja; Gross, Catharina C.; Mansilla, Maria Jose; Teniente-Sera, Aina; WENS, Inez; Billiet, Thibo; Schulte-Mecklenbeck, Andreas; Derdelinckx, Judith; Di Blasi, Daniela; Cabeza, Virginia Palomares; Ribbens, Annemie; Van Hecke, Wim; Barriocanal, Anna Maria; Quirant-Sanchez, Bibiana; Verheij, Herman; Peelen, Sjaak; Cras, Patrick; Snoeckx, Annemiek; Massuet-Vilamajo, Anna; Reverter, Jorge; Dams, Amber; Nijs, Griet; Sampedro, Cristina Calvino; De Cerio, Ascension Lopez Diaz; Inoges, Susana; Prosper, Felipe; HENS, Niel; Wiendl, Heinz; Van Ham, S. Marieke; Berneman, Zwi; Tello, Cristina Ramo & Martinez-Caceres, Eva (2023) Safety, feasibility and tolerability of intranodal and intradermal administration of tolerogenic dendritic cell therapy in active multiple sclerosis. In: Multiple Sclerosis Journal, 29 , p. 598 -600. | - |
item.contributor | Cools, Nathalie | - |
item.contributor | Willekens, Barbara | - |
item.contributor | Presas-Rodriguez, Silvia | - |
item.contributor | Ten Brinke, Anja | - |
item.contributor | Gross, Catharina C. | - |
item.contributor | Mansilla, Maria Jose | - |
item.contributor | Teniente-Sera, Aina | - |
item.contributor | WENS, Inez | - |
item.contributor | Billiet, Thibo | - |
item.contributor | Schulte-Mecklenbeck, Andreas | - |
item.contributor | Derdelinckx, Judith | - |
item.contributor | Di Blasi, Daniela | - |
item.contributor | Cabeza, Virginia Palomares | - |
item.contributor | Ribbens, Annemie | - |
item.contributor | Van Hecke, Wim | - |
item.contributor | Barriocanal, Anna Maria | - |
item.contributor | Quirant-Sanchez, Bibiana | - |
item.contributor | Verheij, Herman | - |
item.contributor | Peelen, Sjaak | - |
item.contributor | Cras, Patrick | - |
item.contributor | Snoeckx, Annemiek | - |
item.contributor | Massuet-Vilamajo, Anna | - |
item.contributor | Reverter, Jorge | - |
item.contributor | Dams, Amber | - |
item.contributor | Nijs, Griet | - |
item.contributor | Sampedro, Cristina Calvino | - |
item.contributor | De Cerio, Ascension Lopez Diaz | - |
item.contributor | Inoges, Susana | - |
item.contributor | Prosper, Felipe | - |
item.contributor | HENS, Niel | - |
item.contributor | Wiendl, Heinz | - |
item.contributor | Van Ham, S. Marieke | - |
item.contributor | Berneman, Zwi | - |
item.contributor | Tello, Cristina Ramo | - |
item.contributor | Martinez-Caceres, Eva | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1352-4585 | - |
crisitem.journal.eissn | 1477-0970 | - |
Appears in Collections: | Research publications |
Files in This Item:
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Session 2.pdf Restricted Access | Published version | 79.52 kB | Adobe PDF | View/Open Request a copy |
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