Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/42174
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dc.contributor.authorLi, Shaobo-
dc.contributor.authorSpitz, Natalia-
dc.contributor.authorGhantous, Akram-
dc.contributor.authorAbrishamcar, Sarina-
dc.contributor.authorREIMANN, Brigitte-
dc.contributor.authorMarques, Irene-
dc.contributor.authorSilver, Matt J.-
dc.contributor.authorAguilar-Lacasaña, Sofía-
dc.contributor.authorKitaba, Negusse-
dc.contributor.authorRezwan, Faisal I.-
dc.contributor.authorRöder, Stefan-
dc.contributor.authorSirignano, Lea-
dc.contributor.authorTuhkanen, Johanna-
dc.contributor.authorMancano, Giulia-
dc.contributor.authorSharp, Gemma C.-
dc.contributor.authorMetayer, Catherine-
dc.contributor.authorMorimoto, Libby-
dc.contributor.authorStein, Dan J.-
dc.contributor.authorZar, Heather J.-
dc.contributor.authorALFANO, Rossella-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorWANG, Congrong-
dc.contributor.authorKajantie, Eero-
dc.contributor.authorKeikkala, Elina-
dc.contributor.authorMustaniemi, Sanna-
dc.contributor.authorRonkainen, Justiina-
dc.contributor.authorSebert, Sylvain-
dc.contributor.authorSilva, Wnurinham-
dc.contributor.authorVääräsmäki, Marja-
dc.contributor.authorJaddoe, Vincent W. V.-
dc.contributor.authorBernstein, Robin M.-
dc.contributor.authorPrentice, Andrew M.-
dc.contributor.authorCosin-Tomas, Marta-
dc.contributor.authorDwyer, Terence-
dc.contributor.authorHåberg, Siri Eldevik-
dc.contributor.authorHerceg, Zdenko-
dc.contributor.authorMagnus, Maria C.-
dc.contributor.authorMunthe-Kaas, Monica Cheng-
dc.contributor.authorPage, Christian M.-
dc.contributor.authorVölker, Maja-
dc.contributor.authorGilles, Maria-
dc.contributor.authorSend, Tabea-
dc.contributor.authorWitt, Stephanie-
dc.contributor.authorZillich, Lea-
dc.contributor.authorGagliardi, Luigi-
dc.contributor.authorRichiardi, Lorenzo-
dc.contributor.authorCzamara, Darina-
dc.contributor.authorRäikkönen, Katri-
dc.contributor.authorChatzi, Lida-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorArshad, S. Hasan-
dc.contributor.authorEwart, Susan-
dc.contributor.authorPLUSQUIN, Michelle-
dc.contributor.authorFelix, Janine F.-
dc.contributor.authorMoore, Sophie E.-
dc.contributor.authorVrijheid, Martine-
dc.contributor.authorHolloway, John W.-
dc.contributor.authorKarmaus, Wilfried-
dc.contributor.authorHerberth, Gunda-
dc.contributor.authorZenclussen, Ana-
dc.contributor.authorStreit, Fabian-
dc.contributor.authorLahti, Jari-
dc.contributor.authorHüls, Anke-
dc.contributor.authorHoang, Thanh T.-
dc.contributor.authorLondon, Stephanie J.-
dc.contributor.authorWiemels, Joseph L.-
dc.date.accessioned2024-01-18T16:05:28Z-
dc.date.available2024-01-18T16:05:28Z-
dc.date.issued2024-
dc.date.submitted2024-01-12T10:31:38Z-
dc.identifier.citationCommunications Biology, 7 (1) (Art N° 66)-
dc.identifier.issn2399-3642-
dc.identifier.urihttp://hdl.handle.net/1942/42174-
dc.description.abstractHigher birth order is associated with altered risk of many disease states. Changes in pla-centation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epi-genomic states on changing disease incidence trends.-
dc.description.sponsorshipWe thank all the participants and their families for this study. We also acknowledge all funding agencies of cohorts involved in this study, as mentioned in the supplementary methods. The overall study at University of Southern California was funded by the National Institute of Environmental Health Sciences (P01ES018172, R01ES09137, R01CA185058), the National Cancer Institute (R01CA175737), and the US Environmental Protection Agency (RD83451101, RD83615901).-
dc.language.isoen-
dc.publisherNATURE PORTFOLIO-
dc.rightsThe Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/.-
dc.subject.otherChild-
dc.subject.otherFemale-
dc.subject.otherHumans-
dc.subject.otherInfant, Newborn-
dc.subject.otherPregnancy-
dc.subject.otherEpigenesis, Genetic-
dc.subject.otherEpigenomics-
dc.subject.otherBirth Order-
dc.subject.otherDNA Methylation-
dc.titleA Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume7-
local.bibliographicCitation.jcatA1-
dc.description.notesWiemels, JL (corresponding author), Univ Southern Calif, Dept Populat & Publ Hlth Sci, Ctr Genet Epidemiol, Los Angeles, CA USA.-
dc.description.noteswiemels@usc.edu-
local.publisher.placeHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr66-
dc.identifier.doi10.1038/s42003-023-05698-x-
dc.identifier.pmid38195839-
dc.identifier.isi001139114900008-
dc.identifier.eissn2399-3642-
local.provider.typeCrossRef-
local.description.affiliation[Li, Shaobo; Wiemels, Joseph L.] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Ctr Genet Epidemiol, Los Angeles, CA USA.-
local.description.affiliation[Spitz, Natalia; Ghantous, Akram; Herceg, Zdenko] Int Agcy Res Canc, Epigen & Mech Branch, Lyon, France.-
local.description.affiliation[Abrishamcar, Sarina; Huels, Anke] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.-
local.description.affiliation[Reimann, Brigitte; Alfano, Rossella; Nawrot, Tim; Wang, Congrong; Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.-
local.description.affiliation[Marques, Irene; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Erasmus MC, Generat Study Grp R, Rotterdam, Netherlands.-
local.description.affiliation[Marques, Irene; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands.-
local.description.affiliation[Silver, Matt J.] London Sch Hyg & Trop Med, Med Res Council Unit Gambia, London, England.-
local.description.affiliation[Aguilar-Lacasana, Sofia; Cosin-Tomas, Marta; Vrijheid, Martine] Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain.-
local.description.affiliation[Aguilar-Lacasana, Sofia; Cosin-Tomas, Marta] Univ Pompeu Fabra UPF, Barcelona, Spain.-
local.description.affiliation[Aguilar-Lacasana, Sofia; Cosin-Tomas, Marta; Vrijheid, Martine] CIBER Epidemiol & Salud Publ, Madrid, Spain.-
local.description.affiliation[Kitaba, Negusse; Rezwan, Faisal I.; Holloway, John W.] Univ Southampton, Southampton Gen Hosp, Fac Med, Human Dev & Hlth, Southampton, England.-
local.description.affiliation[Rezwan, Faisal I.] Aberystwyth Univ, Dept Comp Sci, Aberystwyth SY23 3DB, Dyfed, Wales.-
local.description.affiliation[Roeder, Stefan; Herberth, Gunda; Zenclussen, Ana] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, UFZ, Leipzig, Germany.-
local.description.affiliation[Tuhkanen, Johanna; Czamara, Darina; Raeikkoenen, Katri; Lahti, Jari] Univ Helsinki, Dept Psychol & Logoped, Helsinki, Finland.-
local.description.affiliation[Mancano, Giulia; Sharp, Gemma C.] Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Populat Hlth Sci, Bristol, England.-
local.description.affiliation[Sharp, Gemma C.] Univ Exeter, Fac Hlth & Life Sci, Dept Clin & Biomed Sci, Exeter, Devon, England.-
local.description.affiliation[Metayer, Catherine; Morimoto, Libby] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA USA.-
local.description.affiliation[Stein, Dan J.; Zar, Heather J.] Univ Cape Town, Dept Psychiat, SAMRC Unit Risk & Resilience Mental Disorders, Rondebosch, South Africa.-
local.description.affiliation[Zar, Heather J.] Univ Cape Town, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, ZA-7700 Rondebosch, South Africa.-
local.description.affiliation[Kajantie, Eero; Keikkala, Elina; Mustaniemi, Sanna; Vaeaeraesmaeki, Marja] Univ Oulu, Med Res Ctr Oulu & Bioctr Oulu, Res Unit Biomed & Internal Med, Oulu, Finland.-
local.description.affiliation[Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.-
local.description.affiliation[Kajantie, Eero] Univ Helsinki, Helsinki Univ Hosp, Pediat Res Ctr, Childrens Hosp, Helsinki, Finland.-
local.description.affiliation[Keikkala, Elina; Mustaniemi, Sanna; Vaeaeraesmaeki, Marja] Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Populat Hlth Unit, Oulu, Finland.-
local.description.affiliation[Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham] Univ Oulu, Fac Med, Res Unit Populat Hlth, Oulu, Finland.-
local.description.affiliation[Bernstein, Robin M.] Univ Colorado Boulder, Inst Behav Sci, Dept Sociol, Boulder, CO 80309 USA.-
local.description.affiliation[Prentice, Andrew M.] London Sch Hyg & Trop Med, MRC Unit Gambia, Fajara, Gambia.-
local.description.affiliation[Dwyer, Terence] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Womens & Reprod Hlth, Oxford OX3 9DU, Oxfordshire, England.-
local.description.affiliation[Haberg, Siri Eldevik; Magnus, Maria C.; Page, Christian M.] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway.-
local.description.affiliation[Munthe-Kaas, Monica Cheng] Oslo Univ Hosp, Norwegian Inst Publ Hlth, Oslo, Norway.-
local.description.affiliation[Page, Christian M.] Norwegian Inst Publ Hlth, Dept Phys Hlth & Aging, Div Mental & Phys Hlth, Oslo, Norway.-
local.description.affiliation[Gilles, Maria; Send, Tabea] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Mannheim, Germany.-
local.description.affiliation[Gagliardi, Luigi] AUSL Toscana Nord Ovest, Osped Versilia, Pediat & Neonatol Div, Dept Woman & Child Hlth, Pisa, Italy.-
local.description.affiliation[Richiardi, Lorenzo] Univ Turin, Dept Med Sci, Turin, Italy.-
local.description.affiliation[Chatzi, Lida] Univ Southern Calif, Keck Sch Med USC, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA.-
local.description.affiliation[Vafeiadi, Marina] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece.-
local.description.affiliation[Arshad, S. Hasan; Holloway, John W.] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hampshire, England.-
local.description.affiliation[Arshad, S. Hasan] David Hide Asthma & Allergy Res Ctr, Isle Of Wight, England.-
local.description.affiliation[Ewart, Susan] Michigan State Univ, Coll Vet Med, E Lansing, MI USA.-
local.description.affiliation[Moore, Sophie E.] Kings Coll London, Dept Women & Childrens Hlth, London, England.-
local.description.affiliation[Karmaus, Wilfried] Univ Memphis, Div Epidemiol Biostat & Environm Hlth, Sch Publ Hlth, Memphis, TN 38152 USA.-
local.description.affiliation[Zenclussen, Ana] Univ Leipzig, Med Fac, Saxonian Incubator Clin Translat SIKT, Perinatal Immunol, D-04103 Leipzig, Germany.-
local.description.affiliation[Huels, Anke] Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, GA USA.-
local.description.affiliation[Hoang, Thanh T.; London, Stephanie J.] Natl Inst Environm Hlth Sci, NIH, Epidemiol Branch, Res Triangle Pk, NC USA.-
local.uhasselt.internationalyes-
item.contributorLi, Shaobo-
item.contributorSpitz, Natalia-
item.contributorGhantous, Akram-
item.contributorAbrishamcar, Sarina-
item.contributorREIMANN, Brigitte-
item.contributorMarques, Irene-
item.contributorSilver, Matt J.-
item.contributorAguilar-Lacasaña, Sofía-
item.contributorKitaba, Negusse-
item.contributorRezwan, Faisal I.-
item.contributorRöder, Stefan-
item.contributorSirignano, Lea-
item.contributorTuhkanen, Johanna-
item.contributorMancano, Giulia-
item.contributorSharp, Gemma C.-
item.contributorMetayer, Catherine-
item.contributorMorimoto, Libby-
item.contributorStein, Dan J.-
item.contributorZar, Heather J.-
item.contributorALFANO, Rossella-
item.contributorNAWROT, Tim-
item.contributorWANG, Congrong-
item.contributorKajantie, Eero-
item.contributorKeikkala, Elina-
item.contributorMustaniemi, Sanna-
item.contributorRonkainen, Justiina-
item.contributorSebert, Sylvain-
item.contributorSilva, Wnurinham-
item.contributorVääräsmäki, Marja-
item.contributorJaddoe, Vincent W. V.-
item.contributorBernstein, Robin M.-
item.contributorPrentice, Andrew M.-
item.contributorCosin-Tomas, Marta-
item.contributorDwyer, Terence-
item.contributorHåberg, Siri Eldevik-
item.contributorHerceg, Zdenko-
item.contributorMagnus, Maria C.-
item.contributorMunthe-Kaas, Monica Cheng-
item.contributorPage, Christian M.-
item.contributorVölker, Maja-
item.contributorGilles, Maria-
item.contributorSend, Tabea-
item.contributorWitt, Stephanie-
item.contributorZillich, Lea-
item.contributorGagliardi, Luigi-
item.contributorRichiardi, Lorenzo-
item.contributorCzamara, Darina-
item.contributorRäikkönen, Katri-
item.contributorChatzi, Lida-
item.contributorVafeiadi, Marina-
item.contributorArshad, S. Hasan-
item.contributorEwart, Susan-
item.contributorPLUSQUIN, Michelle-
item.contributorFelix, Janine F.-
item.contributorMoore, Sophie E.-
item.contributorVrijheid, Martine-
item.contributorHolloway, John W.-
item.contributorKarmaus, Wilfried-
item.contributorHerberth, Gunda-
item.contributorZenclussen, Ana-
item.contributorStreit, Fabian-
item.contributorLahti, Jari-
item.contributorHüls, Anke-
item.contributorHoang, Thanh T.-
item.contributorLondon, Stephanie J.-
item.contributorWiemels, Joseph L.-
item.fullcitationLi, Shaobo; Spitz, Natalia; Ghantous, Akram; Abrishamcar, Sarina; REIMANN, Brigitte; Marques, Irene; Silver, Matt J.; Aguilar-Lacasaña, Sofía; Kitaba, Negusse; Rezwan, Faisal I.; Röder, Stefan; Sirignano, Lea; Tuhkanen, Johanna; Mancano, Giulia; Sharp, Gemma C.; Metayer, Catherine; Morimoto, Libby; Stein, Dan J.; Zar, Heather J.; ALFANO, Rossella; NAWROT, Tim; WANG, Congrong; Kajantie, Eero; Keikkala, Elina; Mustaniemi, Sanna; Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham; Vääräsmäki, Marja; Jaddoe, Vincent W. V.; Bernstein, Robin M.; Prentice, Andrew M.; Cosin-Tomas, Marta; Dwyer, Terence; Håberg, Siri Eldevik; Herceg, Zdenko; Magnus, Maria C.; Munthe-Kaas, Monica Cheng; Page, Christian M.; Völker, Maja; Gilles, Maria; Send, Tabea; Witt, Stephanie; Zillich, Lea; Gagliardi, Luigi; Richiardi, Lorenzo; Czamara, Darina; Räikkönen, Katri; Chatzi, Lida; Vafeiadi, Marina; Arshad, S. Hasan; Ewart, Susan; PLUSQUIN, Michelle; Felix, Janine F.; Moore, Sophie E.; Vrijheid, Martine; Holloway, John W.; Karmaus, Wilfried; Herberth, Gunda; Zenclussen, Ana; Streit, Fabian; Lahti, Jari; Hüls, Anke; Hoang, Thanh T.; London, Stephanie J. & Wiemels, Joseph L. (2024) A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation. In: Communications Biology, 7 (1) (Art N° 66).-
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item.accessRightsOpen Access-
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